Prevalence and clinical outcomes of undiagnosed diabetes mellitus and prediabetes among patients with high-risk non-ST-segment elevation acute coronary syndrome

Imagem de Miniatura
Arquivos
art_GIRALDEZ_Prevalence_and_clinical_outcomes_of_undiagnosed_diabetes_mellitus_2013.PDF (491.51 KB)
Citações na Scopus
82
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MOSBY-ELSEVIER
Autores
CLARE, Robert M.
LOPES, Renato D.
DALBY, Anthony J.
PRABHAKARAN, Dorairaj
BROGAN JR., Gerard X.
GIUGLIANO, Robert P.
JAMES, Stefan K.
TANGUAY, Jean-Francois
POLLACK JR., Charles V.
Citação
AMERICAN HEART JOURNAL, v.165, n.6, p.918-925.e2, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background We examined the prevalence of undiagnosed diabetes or prediabetes and associations with ischemic outcomes among non-ST-segment elevation acute coronary syndrome (ACS) patients. Methods We categorized 8795 EARLY ACS trial patients into one of the following groups: ""known diabetes"" (n = 2860 [32.5%]; reported on the case report form), ""undiagnosed diabetes"" (n = 1069 [12.2%]; no diabetes history and fasting glucose >= 126 mg/dL or hemoglobin A(1c) >= 6.5%), ""prediabetes"" (n = 947 [10.8%]; fasting glucose >= 110 to <126 mg/dL, or "" normal"" (n = 3919 [44.5%]). Adjusted associations of known diabetes, undiagnosed diabetes, and prediabetes (versus normal) with 30-day and 1-year outcomes were determined. Results Undiagnosed diabetes was associated with greater 30-day death or myocardial infarction (MI) (ORadj 1.28, 95% CI 1.05-1.57), driven primarily by greater 30-day mortality (ORadj 1.65, 95% CI 1.09-2.48). Known diabetic patients had 30-day death or MI outcomes similar to those of normal patients, but 30-day mortality was higher (ORadj 1.40, 95% CI 1.01-1.93). Prediabetic patients had 30-day death or MI outcomes similar to those of normal patients. One-year mortality was greater among known diabetic patients (HRadj 1.38, 95% CI 1.13-1.67) but not among those with undiagnosed diabetes or prediabetes. Conclusions Undiagnosed diabetes and prediabetes were common among high-risk non-ST-segment elevation ACS patients. Routine screening for undiagnosed diabetes may be useful since these patients seem to have worse short-term outcomes and deserve consideration of alternative management strategies.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/4506
Referências
  1. Alberts MJ, 2011, HEART, V97, P1507, DOI 10.1136/hrt.2010.221788
  2. Anfossi G, 1998, DIABETES CARE, V21, P121, DOI 10.2337/diacare.21.1.121
  3. Angiolillo DJ, 2011, J AM COLL CARDIOL, V58, P30, DOI 10.1016/j.jacc.2011.02.040
  4. Assert R, 2001, DIABETOLOGIA, V44, P188, DOI 10.1007/s001250051598
  5. Capes SE, 2000, LANCET, V355, P773, DOI 10.1016/S0140-6736(99)08415-9
  6. Cowie CC, 2009, DIABETES CARE, V32, P287, DOI 10.2337/dc08-1296
  7. Danaei G, 2011, LANCET, V378, P31, DOI 10.1016/S0140-6736(11)60679-X
  8. Deedwania P, 2008, CIRCULATION, V117, P1610, DOI 10.1161/CIRCULATIONAHA.107.188629
  9. Diaz R, 2007, JAMA-J AM MED ASSOC, V298, P2399, DOI 10.1001/jama.298.20.2399
  10. Esposito K, 2002, CIRCULATION, V106, P2067, DOI 10.1161/01.CIR.0000034509.14906.AE
  11. Ferreiro JL, 2011, CIRCULATION, V123, P798, DOI 10.1161/CIRCULATIONAHA.109.913376
  12. Fox CS, 2004, JAMA-J AM MED ASSOC, V292, P2495, DOI 10.1001/jama.292.20.2495
  13. Giugliano RP, 2005, AM HEART J, V149, P994, DOI 10.1016/j.ahj.2005.03.029
  14. Giugliano RP, 2009, NEW ENGL J MED, V360, P2176, DOI 10.1056/NEJMoa0901316
  15. Gresele P, 2003, J AM COLL CARDIOL, V41, P1013, DOI 10.1016/S0735-1097(02)02972-8
  16. Kawano H, 1999, J AM COLL CARDIOL, V34, P146, DOI 10.1016/S0735-1097(99)00168-0
  17. King H, 1998, DIABETES CARE, V21, P1414, DOI 10.2337/diacare.21.9.1414
  18. Kolman L, 2009, AM J CARDIOL, V104, P470, DOI 10.1016/j.amjcard.2009.04.006
  19. Kosiborod M, 2005, CIRCULATION, V111, P3078, DOI 10.1161/CIRCULATIONAHA.104.517839
  20. Kosiborod M, 2008, CIRCULATION, V117, P1018, DOI 10.1161/CIRCULATIONAHA.107.740498
  21. Lopes RD, 2009, J AM COLL CARDIOL, V53, P1021, DOI 10.1016/j.jacc.2008.12.021
  22. Malmberg K, 1999, CIRCULATION, V99, P2626
  23. Malmberg K, 2005, EUR HEART J, V26, P650, DOI 10.1093/eurheartj/ehi199
  24. Malmberg K, 1997, BRIT MED J, V314, P1512
  25. Mehran R, 2009, EUR HEART J, V30, P1457, DOI 10.1093/eurheartj/ehp110
  26. Mehta SR, 2005, JAMA-J AM MED ASSOC, V293, P437
  27. Olshansky SJ, 2005, NEW ENGL J MED, V352, P1138, DOI 10.1056/NEJMsr043743
  28. Pinto DS, 2005, J AM COLL CARDIOL, V46, P178, DOI 10.1016/j.jacc.2005.03.052
  29. Rao SV, 2004, JAMA-J AM MED ASSOC, V292, P1555, DOI 10.1001/jama.292.13.1555
  30. Roger VL, 2011, CIRCULATION, V123, pE18, DOI 10.1161/CIR.0b013e3182009701
  31. Shaw JE, 2010, DIABETES RES CLIN PR, V87, P4, DOI 10.1016/j.diabres.2009.10.007
  32. Sinnaeve PR, 2009, ARCH INTERN MED, V169, P402, DOI 10.1001/archinternmed.2008.572
  33. Vaidyula VR, 2006, PLATELETS, V17, P577, DOI 10.1080/09537100600760814
  34. Wild S, 2004, DIABETES CARE, V27, P1047, DOI 10.2337/diacare.27.5.1047

Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - ODS/03