Familial hypercholesterolaemia

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDEFESCHE, Joep C.
dc.contributor.authorGIDDING, Samuel S.
dc.contributor.authorHARADA-SHIBA, Mariko
dc.contributor.authorHEGELE, Robert A.
dc.contributor.authorSANTOS, Raul D.
dc.contributor.authorWIERZBICKI, Anthony S.
dc.date.accessioned2018-03-06T15:15:18Z
dc.date.available2018-03-06T15:15:18Z
dc.date.issued2017
dc.description.abstractFamilial hypercholesterolaemia is a common inherited disorder characterized by abnormally elevated serum levels of low-density lipoprotein (LDL) cholesterol from birth, which in time can lead to cardiovascular disease CVD). Most cases are caused by autosomal dominant mutations in LDLR, which encodes the LDL receptor, although mutations in other genes coding for proteins involved in cholesterol metabolism or LDLR function and processing, such as APOB and PCSK9, can also be causative, although less frequently. Several sets of diagnostic criteria for familial hypercholesterolaemia are available; common diagnostic features are an elevated LDL cholesterol level and a family history of hypercholesterolaemia or (premature) CVD. DNA-based methods to identify the underlying genetic defect are desirable but not essential for diagnosis. Cascade screening can contribute to early diagnosis of the disease in family members of an affected individual, which is crucial because familial hypercholesterolaemia can be asymptomatic for decades. Clinical severity depends on the nature of the gene that harbours the causative mutation, among other factors, and is further modulated by the type of mutation. Lifelong LDL cholesterol-lowering treatment substantially improves CVD-free survival and longevity. Statins are the first-line therapy, but additional drugs, such as ezetimibe, bile acid sequestrants, PCSK9 inhibitors and other emerging therapies, are often required.
dc.description.indexMEDLINE
dc.description.sponsorshipAmgen
dc.description.sponsorshipAstellas
dc.description.sponsorshipSanofi
dc.description.sponsorshipMSD
dc.description.sponsorshipAstra Zeneca
dc.description.sponsorshipBoehringer Ingelheim
dc.description.sponsorshipOtsuka
dc.description.sponsorshipDaiichi-Sankyo
dc.description.sponsorshipSanofi/Regeneron
dc.identifier.citationNATURE REVIEWS DISEASE PRIMERS, v.3, article ID 17093, 20p, 2017
dc.identifier.doi10.1038/nrdp.2017.93
dc.identifier.issn2056-676X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/25508
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofNature Reviews Disease Primers
dc.rightsrestrictedAccess
dc.rights.holderCopyright NATURE PUBLISHING GROUP
dc.subject.otherdensity-lipoprotein-receptor
dc.subject.othernational lipid association
dc.subject.otherautosomal-dominant hypercholesterolemia
dc.subject.otherplacebo-controlled trial
dc.subject.othereuropean atherosclerosis society
dc.subject.othertransfer protein inhibitor
dc.subject.otherelevated ldl cholesterol
dc.subject.otheracute coronary syndromes
dc.subject.othermontreal-fh-score
dc.subject.othercardiovascular-disease
dc.subject.wosMedicine, General & Internal
dc.titleFamilial hypercholesterolaemia
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryJapão
hcfmusp.affiliation.countryisonl
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisojp
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalDEFESCHE, Joep C.:Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, POB 22-660, NL-1100 DD Amsterdam, Netherlands
hcfmusp.author.externalGIDDING, Samuel S.:Alfred I DuPont Hosp Children, Nemours Cardiac Ctr, Wilmington, DE USA
hcfmusp.author.externalHARADA-SHIBA, Mariko:Natl Cerebral & Cardiovasc Ctr, Res Inst, Dept Mol Innovat Lipidol, Suita, Osaka, Japan
hcfmusp.author.externalHEGELE, Robert A.:Schulich Sch Med & Dent, Dept Med, London, ON, Canada; Univ Western Ontario, Robarts Res Inst, 4288A 1151 Richmond St North, London, ON N6A 5B7, Canada
hcfmusp.author.externalWIERZBICKI, Anthony S.:Guys & St Thomas Hosp, Metab Med & Chem Pathol, London, England
hcfmusp.citation.scopus299
hcfmusp.contributor.author-fmusphcRAUL DIAS DOS SANTOS FILHO
hcfmusp.description.articlenumber17093
hcfmusp.description.volume3
hcfmusp.origemWOS
hcfmusp.origem.pubmed29219151
hcfmusp.origem.scopus2-s2.0-85045988080
hcfmusp.origem.wosWOS:000417650300001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
hcfmusp.relation.referenceAatre RD, 2011, CIRC-CARDIOVASC GENE, V4, P81, DOI 10.1161/CIRCGENETICS.110.957365
hcfmusp.relation.referenceAbifadel M, 2003, NAT GENET, V34, P154, DOI 10.1038/ng1161
hcfmusp.relation.referenceAdemi Z, 2014, J CLIN LIPIDOL, V8, P390, DOI 10.1016/j.jacl.2014.05.008
hcfmusp.relation.referenceAgard A, 2005, PATIENT EDUC COUNS, V57, P162, DOI 10.1016/j.pec.2004.05.010
hcfmusp.relation.referenceAlfonsi JE, 2016, CURR ATHEROSCLER REP, V18, DOI 10.1007/s11883-016-0573-6
hcfmusp.relation.referenceAmundsen AL, 2006, ATHEROSCLEROSIS, V189, P451, DOI 10.1016/j.atherosclerosis.2006.01.002
hcfmusp.relation.referenceAndersen LH, 2016, J CLIN LIPIDOL, V10, P1297, DOI 10.1016/j.jacl.2016.09.009
hcfmusp.relation.referenceAndersen R, 2016, J CLIN LIPIDOL, V10, P225, DOI 10.1016/j.jacl.2015.12.019
hcfmusp.relation.referenceANDERSON RGW, 1976, P NATL ACAD SCI USA, V73, P2434, DOI 10.1073/pnas.73.7.2434
hcfmusp.relation.referenceAwan Z, 2013, ATHEROSCLEROSIS, V231, P218, DOI 10.1016/j.atherosclerosis.2013.09.007
hcfmusp.relation.referenceBell DA, 2015, ATHEROSCLEROSIS, V239, P93, DOI 10.1016/j.atherosclerosis.2014.12.036
hcfmusp.relation.referenceBenn M, 2012, J CLIN ENDOCR METAB, V97, P3956, DOI 10.1210/jc.2012-1563
hcfmusp.relation.referenceBesseling J, 2016, J AM COLL CARDIOL, V68, P252, DOI 10.1016/j.jacc.2016.04.054
hcfmusp.relation.referenceBesseling J, 2015, JAMA-J AM MED ASSOC, V313, P1029, DOI 10.1001/jama.2015.1206
hcfmusp.relation.referenceBlom DJ, 2017, CIRCULATION, V136, P332, DOI 10.1161/CIRCULATIONAHA.117.028208
hcfmusp.relation.referenceBourbon M, 2017, CURR OPIN LIPIDOL, V28, P120, DOI 10.1097/MOL.0000000000000404
hcfmusp.relation.referenceBrahm AJ, 2016, CURR OPIN LIPIDOL, V27, P131, DOI 10.1097/MOL.0000000000000270
hcfmusp.relation.referenceBROWN MS, 1986, SCIENCE, V232, P34, DOI 10.1126/science.3513311
hcfmusp.relation.referenceBROWN MS, 1974, SCIENCE, V185, P61, DOI 10.1126/science.185.4145.61
hcfmusp.relation.referenceCannon CP, 2015, NEW ENGL J MED, V372, P2387, DOI 10.1056/NEJMoa1410489
hcfmusp.relation.referenceClaassen L, 2012, PSYCHOL HEALTH MED, V17, P511, DOI 10.1080/13548506.2011.644246
hcfmusp.relation.referenceCuchel M, 2014, EUR HEART J, V35, P2146, DOI 10.1093/eurheartj/ehu274
hcfmusp.relation.referenceCuchel M, 2013, LANCET, V381, P40, DOI 10.1016/S0140-6736(12)61731-0
hcfmusp.relation.referenceCupido AJ, 2017, CURR OPIN LIPIDOL, V28, P367, DOI 10.1097/MOL.0000000000000428
hcfmusp.relation.referenceDaniels SR, 2011, J CLIN LIPIDOL, V5, pS30, DOI 10.1016/j.jacl.2011.03.453
hcfmusp.relation.referenceDe Backer G, 2015, ATHEROSCLEROSIS, V241, P169, DOI 10.1016/j.atherosclerosis.2015.04.809
hcfmusp.relation.referencedeGoma EM, 2016, CIRC-CARDIOVASC GENE, V9, P240, DOI 10.1161/CIRCGENETICS.116.001381
hcfmusp.relation.referenceDequeker J, 2004, ISRAEL MED ASSOC J, V6, P505
hcfmusp.relation.referenceDERKALOUSTIAN VM, 1980, AM J MED GENET, V7, P187, DOI 10.1002/ajmg.1320070212
hcfmusp.relation.referenceDo R, 2015, NATURE, V518, P102, DOI 10.1038/nature13917
hcfmusp.relation.referenceEapen DJ, 2012, J CLIN LIPIDOL, V6, P88, DOI 10.1016/j.jacl.2011.08.005
hcfmusp.relation.referenceENDO A, 1976, J ANTIBIOT, V29, P1346, DOI 10.7164/antibiotics.29.1346
hcfmusp.relation.referenceERKELENS DW, 1989, JAMA-J AM MED ASSOC, V262, P2092
hcfmusp.relation.referenceExpert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, 2011, Pediatrics, V128 Suppl 5, pS213, DOI 10.1542/peds.2009-2107C
hcfmusp.relation.referenceFagge C. H., 1873, T PATHOL SOC LOND, V24, P242
hcfmusp.relation.referenceFellin R, 2015, GENE, V555, P23, DOI 10.1016/j.gene.2014.09.020
hcfmusp.relation.referenceFerence BA, 2017, EUR HEART J, V38, P2459, DOI 10.1093/eurheartj/ehx144
hcfmusp.relation.referenceFouchier SW, 2014, CIRC RES, V115, P552, DOI 10.1161/CIRCRESAHA.115.304660
hcfmusp.relation.referenceFouchier SW, 2013, CURR OPIN LIPIDOL, V24, P332, DOI 10.1097/MOL.0b013e328361f6c6
hcfmusp.relation.referenceFrich JC, 2006, ANN FAM MED, V4, P198, DOI 10.1370/afm.529
hcfmusp.relation.referenceFutema M, 2015, CLIN CHEM, V61, P231, DOI 10.1373/clinchem.2014.231365
hcfmusp.relation.referenceGagne C, 2002, CIRCULATION, V105, P2469, DOI 10.1161/01.CIR.0000018744.58460.62
hcfmusp.relation.referenceGalabova G, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0114469
hcfmusp.relation.referenceGenest J, 2014, CAN J CARDIOL, V30, P1471, DOI 10.1016/j.cjca.2014.09.028
hcfmusp.relation.referenceGidding SS, 2015, CIRCULATION, V132, P2167, DOI 10.1161/CIR.0000000000000297
hcfmusp.relation.referenceGOLDSTEIN JL, 1973, P NATL ACAD SCI USA, V70, P2804, DOI 10.1073/pnas.70.10.2804
hcfmusp.relation.referenceGoldstein JL, 2001, METABOLIC MOL BASES, VII, P2863
hcfmusp.relation.referenceGoldstein JL, 2009, ARTERIOSCL THROM VAS, V29, P431, DOI 10.1161/ATVBAHA.108.179564
hcfmusp.relation.referenceGraesdal A, 2012, J CLIN LIPIDOL, V6, P331, DOI 10.1016/j.jacl.2012.03.004
hcfmusp.relation.referenceGryn SE, 2016, CURR OPIN LIPIDOL, V27, P579, DOI 10.1097/MOL.0000000000000354
hcfmusp.relation.referenceHaralambos K, 2015, ATHEROSCLEROSIS, V240, P190, DOI 10.1016/j.atherosclerosis.2015.03.003
hcfmusp.relation.referenceHegele RA, 2015, ARTERIOSCL THROM VAS, V35, P2269, DOI 10.1161/ATVBAHA.115.306442
hcfmusp.relation.referenceHegele RA, 2015, CURR OPIN LIPIDOL, V26, P103, DOI 10.1097/MOL.0000000000000163
hcfmusp.relation.referenceHegele RA, 2009, NAT REV GENET, V10, P109, DOI 10.1038/nrg2481
hcfmusp.relation.referenceHomsma SJM, 2008, EUR J HUM GENET, V16, P14, DOI 10.1038/sj.ejhg.5201940
hcfmusp.relation.referenceHopkins PN, 2015, CIRC-CARDIOVASC GENE, V8, P823, DOI 10.1161/CIRCGENETICS.115.001129
hcfmusp.relation.referenceHuijgen R, 2012, EUR J HUM GENET, V20, P722, DOI 10.1038/ejhg.2012.5
hcfmusp.relation.referenceHuijgen R, 2011, CIRC-CARDIOVASC GENE, V4, P413, DOI 10.1161/CIRCGENETICS.110.959239
hcfmusp.relation.referenceHuijgen R, 2010, CLIN THER, V32, P615, DOI 10.1016/j.clinthera.2010.04.014
hcfmusp.relation.referenceIacocca MA, 2017, EXPERT REV MOL DIAGN, V17, P641, DOI 10.1080/14737159.2017.1332997
hcfmusp.relation.referenceIto MK, 2011, J CLIN LIPIDOL, V5, pS38, DOI 10.1016/j.jacl.2011.04.001
hcfmusp.relation.referenceJansen ACM, 2002, CURR OPIN LIPIDOL, V13, P165, DOI 10.1097/00041433-200204000-00008
hcfmusp.relation.referenceKassim SH, 2013, HUM GENE THER, V24, P19, DOI 10.1089/hum.2012.108
hcfmusp.relation.referenceKastelein JJP, 2008, NEW ENGL J MED, V358, P1431, DOI 10.1056/NEJMoa0800742
hcfmusp.relation.referenceKastelein JJP, 2017, J CLIN LIPIDOL, V11, P195, DOI 10.1016/j.jacl.2016.12.004
hcfmusp.relation.referenceKHACHADURIAN AK, 1964, AM J MED, V37, P402, DOI 10.1016/0002-9343(64)90196-2
hcfmusp.relation.referenceKhera AV, 2016, J AM COLL CARDIOL, V67, P2578, DOI 10.1016/j.jacc.2016.03.520
hcfmusp.relation.referenceKlancar G, 2015, J AM COLL CARDIOL, V66, P1250, DOI 10.1016/j.jacc.2015.07.017
hcfmusp.relation.referenceKusters DM, 2012, ARCH DIS CHILD, V97, P272, DOI 10.1136/archdischild-2011-300081
hcfmusp.relation.referenceLandmesser U, 2017, EUR HEART J, V38, P2245, DOI 10.1093/eurheartj/ehw480
hcfmusp.relation.referenceLangsted A, 2016, LANCET DIABETES ENDO, V4, P577, DOI 10.1016/S2213-8587(16)30042-0
hcfmusp.relation.referenceLansberg P J, 2000, Ned Tijdschr Geneeskd, V144, P1437
hcfmusp.relation.referenceLiyanage KE, 2011, CRIT REV CL LAB SCI, V48, P1, DOI 10.3109/10408363.2011.565585
hcfmusp.relation.referenceLozano P, 2016, JAMA-J AM MED ASSOC, V316, P645, DOI 10.1001/jama.2016.6176
hcfmusp.relation.referenceLusis AJ, 2000, NATURE, V407, P233, DOI 10.1038/35025203
hcfmusp.relation.referenceLyceum CME Inc, 2013, PATIENT MONITORING S
hcfmusp.relation.referenceMAHER VMG, 1995, JAMA-J AM MED ASSOC, V274, P1771, DOI 10.1001/jama.274.22.1771
hcfmusp.relation.referenceMancini GBJ, 2013, CAN J CARDIOL, V29, P1553, DOI 10.1016/j.cjca.2013.09.023
hcfmusp.relation.referenceMarais Adrian David, 2004, Semin Vasc Med, V4, P93
hcfmusp.relation.referenceMarks D, 2003, ATHEROSCLEROSIS, V168, P1, DOI 10.1016/S0021-9150(02)00330-1
hcfmusp.relation.referenceMiller PE, 2015, J CLIN LIPIDOL, V9, P676, DOI 10.1016/j.jacl.2015.06.015
hcfmusp.relation.referenceMoore KJ, 2005, J CLIN INVEST, V115, P2192, DOI 10.1172/JCI24061
hcfmusp.relation.referenceMOORJANI S, 1989, ARTERIOSCLEROSIS, V9, P211, DOI 10.1161/01.ATV.9.2.211
hcfmusp.relation.referenceMOORJANI S, 1993, LANCET, V341, P1303, DOI 10.1016/0140-6736(93)90815-X
hcfmusp.relation.referenceMOUTAFIS CD, 1977, ATHEROSCLEROSIS, V26, P329, DOI 10.1016/0021-9150(77)90085-5
hcfmusp.relation.referenceMuller C, 1938, ACTA MED SCAND, P75
hcfmusp.relation.referenceNanchen D, 2016, CIRCULATION, V134, P698, DOI 10.1161/CIRCULATIONAHA.116.023007
hcfmusp.relation.referenceNational Institute for Health and Care Excellence, 2016, EZ TREAT PRIM HET FA
hcfmusp.relation.referenceNherera L, 2011, HEART, V97, P1175, DOI 10.1136/hrt.2010.213975
hcfmusp.relation.referenceNordestgaard BG, 2017, EUR HEART J, V38, P1580, DOI 10.1093/eurheartj/ehx136
hcfmusp.relation.referenceNordestgaard BG, 2013, EUR HEART J, V34, P3478, DOI 10.1093/eurheartj/eht273
hcfmusp.relation.referenceOrringer CE, 2017, J CLIN LIPIDOL, V11, P880, DOI [10.1016/j.jacl.2017.05.001, 10.1016/j.jac1.2017.05.001]
hcfmusp.relation.referenceOse L, 2008, CURR CARDIOL REV, V4, P60, DOI 10.2174/157340308783565401
hcfmusp.relation.referencePaquette M, 2017, J CLIN LIPIDOL, V11, P1161, DOI 10.1016/j.jacl.2017.07.008
hcfmusp.relation.referencePaquette M, 2017, J CLIN LIPIDOL, V11, P80, DOI 10.1016/j.jacl.2016.10.004
hcfmusp.relation.referencePatel SB, 2014, CURR OPIN LIPIDOL, V25, P169, DOI 10.1097/MOL.0000000000000071
hcfmusp.relation.referencePerak AM, 2016, CIRCULATION, V134, P9, DOI 10.1161/CIRCULATIONAHA.116.022335
hcfmusp.relation.referencede Isla LP, 2017, CIRCULATION, V135, P2133, DOI 10.1161/CIRCULATIONAHA.116.024541
hcfmusp.relation.referencede Isla LP, 2016, ARTERIOSCL THROM VAS, V36, P2004, DOI 10.1161/ATVBAHA.116.307514
hcfmusp.relation.referenceQian L. J., 2017, SCI REP, V7, P238
hcfmusp.relation.referenceRaal FJ, 2017, LANCET DIABETES ENDO, V5, P280, DOI 10.1016/S2213-8587(17)30044-X
hcfmusp.relation.referenceRaal FJ, 2015, LANCET, V385, P331, DOI 10.1016/S0140-6736(14)61399-4
hcfmusp.relation.referenceRaal FJ, 2015, LANCET, V385, P341, DOI 10.1016/S0140-6736(14)61374-X
hcfmusp.relation.referenceRaal FJ, 2012, ATHEROSCLEROSIS, V223, P262, DOI 10.1016/j.atherosclerosis.2012.02.019
hcfmusp.relation.referenceRaal FJ, 2011, CIRCULATION, V124, P2202, DOI 10.1161/CIRCULATIONAHA.111.042523
hcfmusp.relation.referenceRaal FJ, 2010, LANCET, V375, P998, DOI 10.1016/S0140-6736(10)60284-X
hcfmusp.relation.referenceRay KK, 2017, NEW ENGL J MED, V376, P1430, DOI 10.1056/NEJMoa1615758
hcfmusp.relation.referenceRidker PM, 2017, NEW ENGL J MED, V376, P1527, DOI 10.1056/NEJMoa1701488
hcfmusp.relation.referenceRios J, 2010, HUM MOL GENET, V19, P4313, DOI 10.1093/hmg/ddq352
hcfmusp.relation.referenceRobinson JG, 2016, J AM COLL CARDIOL, V68, P2412, DOI 10.1016/j.jacc.2016.09.928
hcfmusp.relation.referenceRobinson JG, 2011, J CLIN LIPIDOL, V5, pS18, DOI 10.1016/j.jacl.2011.03.451
hcfmusp.relation.referenceSabatine MS, 2017, NEW ENGL J MED, V376, P1713, DOI 10.1056/NEJMoa1615664
hcfmusp.relation.referenceSantos RD, 2017, CURR OPIN LIPIDOL, V28, P130, DOI 10.1097/MOL.0000000000000391
hcfmusp.relation.referenceSantos RD, 2016, LANCET DIABETES ENDO, V4, P850, DOI 10.1016/S2213-8587(16)30041-9
hcfmusp.relation.referenceSantos RD, 2016, LANCET DIABETES ENDO, V4, P553, DOI 10.1016/S2213-8587(16)30082-1
hcfmusp.relation.referenceSantos RD, 2015, J ATHEROSCLER THROMB, V22, P869, DOI 10.5551/jat.31237
hcfmusp.relation.referenceSantos RD, 2014, CURR OPIN LIPIDOL, V25, P183, DOI 10.1097/MOL.0000000000000073
hcfmusp.relation.referenceSbrana F, 2017, EUR J PREV CARDIOL, V24, P1528, DOI 10.1177/2047487317712419
hcfmusp.relation.referenceSchonewille M, 2016, CURR OPIN LIPIDOL, V27, P295, DOI 10.1097/MOL.0000000000000303
hcfmusp.relation.referenceScientific Steering Committee on behalf of the Simon Broome Register Group, 1991, BMJ-BRIT MED J, V303, P893
hcfmusp.relation.referenceShi ZM, 2014, INT J CARDIOL, V174, P834, DOI 10.1016/j.ijcard.2014.04.165
hcfmusp.relation.referenceSjouke B, 2015, EUR HEART J, V36, P560, DOI 10.1093/eurheartj/ehu058
hcfmusp.relation.referenceSmilde TJ, 2001, LANCET, V357, P577, DOI 10.1016/S0140-6736(00)04053-8
hcfmusp.relation.referenceSMIT JWA, 1995, EUR J CLIN INVEST, V25, P79, DOI 10.1111/j.1365-2362.1995.tb01530.x
hcfmusp.relation.referenceSomanathan S, 2014, CIRC RES, V115, P591, DOI 10.1161/CIRCRESAHA.115.304008
hcfmusp.relation.referenceStein EA, 2017, J AM COLL CARDIOL, V70, P1162, DOI 10.1016/j.jacc.2017.06.058
hcfmusp.relation.referenceSteyn K, 1996, HUM GENET, V98, P479, DOI 10.1007/s004390050243
hcfmusp.relation.referenceStitziel NO, 2013, ARTERIOSCL THROM VAS, V33, P2909, DOI 10.1161/ATVBAHA.113.302426
hcfmusp.relation.referenceStroes ES, 2015, EUR HEART J, V36, P1012, DOI 10.1093/eurheartj/ehv043
hcfmusp.relation.referenceSTROES ESG, 1995, LANCET, V346, P467, DOI 10.1016/S0140-6736(95)91322-X
hcfmusp.relation.referenceSturm AC, 2016, FRONT CARDIOVASC MED, V3, DOI 10.3389/fcvm.2016.00011
hcfmusp.relation.referenceTalmud PJ, 2013, LANCET, V381, P1293, DOI 10.1016/S0140-6736(12)62127-8
hcfmusp.relation.referenceThe HPS3-TIMI55-REVEAL Collaborative Group, 2017, NEW ENGL J MED, V377, P1217
hcfmusp.relation.referenceThompson GR, 2013, ATHEROSCLEROSIS SUPP, V14, P67, DOI 10.1016/j.atherosclerosissup.2012.10.001
hcfmusp.relation.referenceTHOMPSON GR, 1995, CAN J CARDIOL, V345, P811
hcfmusp.relation.referenceTonstad S, 1996, J PEDIATR-US, V129, P42, DOI 10.1016/S0022-3476(96)70188-9
hcfmusp.relation.referenceTurner T, 2015, CLIN THER, V37, P2751, DOI 10.1016/j.clinthera.2015.09.004
hcfmusp.relation.referenceUmans-Eckenhausen MAW, 2001, LANCET, V357, P165, DOI 10.1016/S0140-6736(00)03587-X
hcfmusp.relation.referenceVallejo-Vaz AJ, 2016, ATHEROSCLEROSIS SUPP, V22, P1, DOI 10.1016/j.atherosclerosissup.2016.10.001
hcfmusp.relation.referencevan der Graaf A, 2008, ANN INTERN MED, V148, P712, DOI 10.7326/0003-4819-148-9-200805060-00022
hcfmusp.relation.referenceVarvel S. A., 2015, J CLIN LIPIDOL, V9, P103
hcfmusp.relation.referenceVersmissen J, 2008, BRIT MED J, V337, DOI 10.1136/bmj.a2423
hcfmusp.relation.referenceWALD DS, 2016, ENGL J MED, V375, P1628, DOI 10.1056/NEJMOA1602777
hcfmusp.relation.referenceWang A, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.003294
hcfmusp.relation.referenceWang J, 2005, J LIPID RES, V46, P366, DOI 10.1194/jlr.D400030-JLR200
hcfmusp.relation.referenceWang J, 2016, ARTERIOSCL THROM VAS, V36, P2439, DOI 10.1161/ATVBAHA.116.308027
hcfmusp.relation.referenceWang LDR, 2017, CAN J CARDIOL, V33, P334, DOI [10.1016/j.cjca.2016.11.003, 10.1016/j.cjca.2016.1.003]
hcfmusp.relation.referenceWatts GF, 2015, INT J CARDIOL, V185, P69, DOI 10.1016/j.ijcard.2015.03.027
hcfmusp.relation.referenceWatts GF, 2014, INT J CARDIOL, V171, P309, DOI 10.1016/j.ijcard.2013.11.025
hcfmusp.relation.referenceWeng SF, 2015, ATHEROSCLEROSIS, V238, P336, DOI 10.1016/j.atherosclerosis.2014.12.034
hcfmusp.relation.referenceWiegman A, 2015, EUR HEART J, V36, P2425, DOI 10.1093/eurheartj/ehv157
hcfmusp.relation.referenceWierzbicki AS, 2016, CLIN MED, V16, P353, DOI 10.7861/clinmedicine.16-4-353
hcfmusp.relation.referenceWierzbicki AS, 2015, CURR OPIN LIPIDOL, V26, P475, DOI 10.1097/MOL.0000000000000238
hcfmusp.relation.referenceWierzbicki AS, 2008, BRIT MED J, V337, DOI 10.1136/bmj.a1095
hcfmusp.relation.referenceWILKINSON CF, 1948, ANN INTERN MED, V29, P671, DOI 10.7326/0003-4819-29-4-671
hcfmusp.relation.referenceWiller CJ, 2013, NAT GENET, V45, P1274, DOI 10.1038/ng.2797
hcfmusp.relation.referenceWILLIAMS RR, 1993, AM J CARDIOL, V72, P171, DOI 10.1016/0002-9149(93)90155-6
hcfmusp.relation.referenceWittekoek ME, 1998, CIRCULATION, V97, P729
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication342e0234-2bff-4c3b-a782-40e80d798912
relation.isAuthorOfPublication.latestForDiscovery342e0234-2bff-4c3b-a782-40e80d798912
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_DEFESCHE_Familial_hypercholesterolaemia_2017.PDF
Tamanho:
4.44 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - ODS/03