Recommendations of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism for the diagnosis of Cushing’s disease in Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMACHADO, Márcio Carlos
dc.contributor.authorFRAGOSO, Maria Candida Barisson Vilares
dc.contributor.authorMOREIRA, Ayrton Custódio
dc.contributor.authorBOGUSZEWSKI, César Luiz
dc.contributor.authorVIEIRA NETO, Leonardo
dc.contributor.authorNAVES, Luciana A.
dc.contributor.authorVILAR, Lucio
dc.contributor.authorARAÚJO, Luiz Antônio de
dc.contributor.authorCZEPIELEWSKI, Mauro A.
dc.contributor.authorGADELHA, Monica R.
dc.contributor.authorMUSOLINO, Nina Rosa Castro
dc.contributor.authorMIRANDA, Paulo Augusto C.
dc.contributor.authorBRONSTEIN, Marcello Delano
dc.contributor.authorRIBEIRO-OLIVEIRA JR., Antônio
dc.date.accessioned2016-07-27T19:06:44Z
dc.date.available2016-07-27T19:06:44Z
dc.date.issued2016
dc.description.abstractABSTRACT Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers. Arch Endocrinol Metab. 2016;60(3):267-86
dc.description.indexMEDLINE
dc.identifier.citationARCHIVES OF ENDOCRINOLOGY METABOLISM, v.60, n.3, p.267-286, 2016
dc.identifier.doi10.1590/2359-3997000000174
dc.identifier.eissn2359-4292
dc.identifier.issn2359-3997
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14778
dc.language.isoeng
dc.publisherSociedade Brasileira de Endocrinologia e Metabologia
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.rightsopenAccess
dc.rights.holderCopyright Sociedade Brasileira de Endocrinologia e Metabologia
dc.subjectCushing’s disease
dc.subjectCushing’s syndrome
dc.subjectdiagnosis
dc.subject.otherCORTICOTROPIN-RELEASING HORMONE
dc.subject.otherINFERIOR PETROSAL SINUS
dc.subject.otherNIGHT SALIVARY CORTISOL
dc.subject.otherDEXAMETHASONE-SUPPRESSION TEST
dc.subject.otherURINARY FREE CORTISOL
dc.subject.otherPOSITRON-EMISSION-TOMOGRAPHY
dc.subject.otherECTOPIC-ACTH SYNDROME
dc.subject.otherADRENOCORTICOTROPIN-SECRETING TUMORS
dc.subject.otherTYPE-2 DIABETES-MELLITUS
dc.subject.otherSOMATOSTATIN RECEPTOR SCINTIGRAPHY
dc.titleRecommendations of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism for the diagnosis of Cushing’s disease in Brazil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalMOREIRA, Ayrton Custódio:Universidade de São Paulo, Brazil
hcfmusp.author.externalBOGUSZEWSKI, César Luiz:Universidade Federal do Paraná, Brazil
hcfmusp.author.externalVIEIRA NETO, Leonardo:Universidade Federal do Rio de Janeiro, Brazil
hcfmusp.author.externalNAVES, Luciana A.:Universidade de Brasília, Brazil
hcfmusp.author.externalVILAR, Lucio:Universidade Federal de Pernambuco, Brazil
hcfmusp.author.externalARAÚJO, Luiz Antônio de:Endoville, Brasil
hcfmusp.author.externalCZEPIELEWSKI, Mauro A.:Universidade Federal do Rio Grande do Sul, Brazil
hcfmusp.author.externalGADELHA, Monica R.:Universidade Federal do Rio de Janeiro, Brazil
hcfmusp.author.externalMIRANDA, Paulo Augusto C.:Santa Casa de Misericórdia de Belo Horizonte, Brazil
hcfmusp.author.externalRIBEIRO-OLIVEIRA JR., Antônio:Universidade Federal de Minas Gerais, Brazil
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcMARCIO CARLOS MACHADO
hcfmusp.contributor.author-fmusphcMARIA CANDIDA BARISSON VILLARES FRAGOSO
hcfmusp.contributor.author-fmusphcNINA ROSA DE CASTRO MUSOLINO
hcfmusp.contributor.author-fmusphcMARCELLO DELANO BRONSTEIN
hcfmusp.description.beginpage267
hcfmusp.description.endpage286
hcfmusp.description.issue3
hcfmusp.description.volume60
hcfmusp.origemWOS
hcfmusp.origem.pubmed27355856
hcfmusp.origem.scieloSCIELO:S2359-39972016000300267
hcfmusp.origem.scopus2-s2.0-84989225532
hcfmusp.origem.wosWOS:000380358600013
hcfmusp.scopus.lastupdate2024-04-12
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