Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | MENEZES FILHO, Helio Ranes de | |
dc.contributor.author | GRANDI, Giuliano | |
dc.contributor.author | CARDOSO, Ludimila Paula Vaz | |
dc.contributor.author | SILVA, Juan Felipe Galvao da | |
dc.contributor.author | MACHADO, Soraia Mafra | |
dc.contributor.author | ALMEIDA-NETO, Cesar de | |
dc.contributor.author | SABINO, Ester Cerdeira | |
dc.contributor.author | MENDES-CORREA, Maria Cassia | |
dc.date.accessioned | 2023-12-15T18:52:40Z | |
dc.date.available | 2023-12-15T18:52:40Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Among individuals coinfected with HCV and HIV, studies of mortality from non-hepatic causes have shown inconsistent results. The aim of this study was to investigate the contribution of HCV and HIV co-infection to mortality from hepatic and non-hepatic causes in Brazil. This retrospective cohort study included blood donors from Funda & ccedil;& atilde;o Pr & oacute;-Sangue de S & atilde;o Paulo (FPS) who were followed from 1994 to 2016 to compare mortality and its causes between HIV-HCV coinfected individuals versus those seronegative for all tested infections. Records from the FPS database and the Mortality Information System were linked through a probabilistic record Relationship (RL). The Hazard Ratio (HR) was estimated using Cox multiple regression models. HCV-HIV coinfected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 14.54), non-liver neoplasms (HR = 2.55), infections (HR = 10.37) and liver disease (HR = 7.0). In addition, HCV mono-infected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 2.23), liver cancer (HR = 32.21), liver disease (HR = 14.92), infection (HR = 3.22), and trauma (HR = 1.68). Individuals coinfected with HCV and HIV have increased overall mortality and death due to infections, liver diseases and non-liver neoplasms as compared to those uninfected with HCV and HIV. | eng |
dc.description.index | MEDLINE | |
dc.description.index | PubMed | |
dc.description.index | WoS | |
dc.description.index | Scopus | |
dc.identifier.citation | BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.27, n.5, article ID 102810, 6p, 2023 | |
dc.identifier.doi | 10.1016/j.bjid.2023.102810 | |
dc.identifier.eissn | 1678-4391 | |
dc.identifier.issn | 1413-8670 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/57436 | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER BRAZIL | eng |
dc.relation.ispartof | Brazilian Journal of Infectious Diseases | |
dc.rights | openAccess | eng |
dc.rights.holder | Copyright ELSEVIER BRAZIL | eng |
dc.subject | Hepatitis C | eng |
dc.subject | HIV | eng |
dc.subject | Mortality | eng |
dc.subject.other | hepatitis-c virus | eng |
dc.subject.other | cause-specific mortality | eng |
dc.subject.other | all-cause | eng |
dc.subject.other | infection | eng |
dc.subject.other | death | eng |
dc.subject.other | liver | eng |
dc.subject.other | individuals | eng |
dc.subject.other | trends | eng |
dc.subject.other | rates | eng |
dc.subject.wos | Infectious Diseases | eng |
dc.title | Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV | eng |
dc.type | article | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
dspace.entity.type | Publication | |
hcfmusp.author.external | GRANDI, Giuliano:Univ Fed Sao Paulo, Med Sch, Sao Paulo, SP, Brazil | |
hcfmusp.author.external | CARDOSO, Ludimila Paula Vaz:Univ Fed Jatai, Dept Hlth Sci, Jatai, GO, Brazil | |
hcfmusp.author.external | SILVA, Juan Felipe Galvao da:Univ Fed Jatai, Dept Hlth Sci, Jatai, GO, Brazil | |
hcfmusp.citation.scopus | 0 | |
hcfmusp.contributor.author-fmusphc | HELIO RANES DE MENEZES FILHO | |
hcfmusp.contributor.author-fmusphc | SORAIA MAFRA MACHADO | |
hcfmusp.contributor.author-fmusphc | CESAR DE ALMEIDA NETO | |
hcfmusp.contributor.author-fmusphc | ESTER CERDEIRA SABINO | |
hcfmusp.contributor.author-fmusphc | MARIA CASSIA JACINTHO MENDES CORREA | |
hcfmusp.description.articlenumber | 102810 | |
hcfmusp.description.issue | 5 | |
hcfmusp.description.volume | 27 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 37813358 | |
hcfmusp.origem.scopus | 2-s2.0-85174051469 | |
hcfmusp.origem.wos | WOS:001098588700001 | |
hcfmusp.publisher.city | RIO DE JANEIRO | eng |
hcfmusp.publisher.country | BRAZIL | eng |
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hcfmusp.scopus.lastupdate | 2024-05-17 | |
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