Survival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCV

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMENEZES FILHO, Helio Ranes de
dc.contributor.authorGRANDI, Giuliano
dc.contributor.authorCARDOSO, Ludimila Paula Vaz
dc.contributor.authorSILVA, Juan Felipe Galvao da
dc.contributor.authorMACHADO, Soraia Mafra
dc.contributor.authorALMEIDA-NETO, Cesar de
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorMENDES-CORREA, Maria Cassia
dc.date.accessioned2023-12-15T18:52:40Z
dc.date.available2023-12-15T18:52:40Z
dc.date.issued2023
dc.description.abstractAmong individuals coinfected with HCV and HIV, studies of mortality from non-hepatic causes have shown inconsistent results. The aim of this study was to investigate the contribution of HCV and HIV co-infection to mortality from hepatic and non-hepatic causes in Brazil. This retrospective cohort study included blood donors from Funda & ccedil;& atilde;o Pr & oacute;-Sangue de S & atilde;o Paulo (FPS) who were followed from 1994 to 2016 to compare mortality and its causes between HIV-HCV coinfected individuals versus those seronegative for all tested infections. Records from the FPS database and the Mortality Information System were linked through a probabilistic record Relationship (RL). The Hazard Ratio (HR) was estimated using Cox multiple regression models. HCV-HIV coinfected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 14.54), non-liver neoplasms (HR = 2.55), infections (HR = 10.37) and liver disease (HR = 7.0). In addition, HCV mono-infected individuals compared to seronegative individuals had a higher risk of death from all causes (HR = 2.23), liver cancer (HR = 32.21), liver disease (HR = 14.92), infection (HR = 3.22), and trauma (HR = 1.68). Individuals coinfected with HCV and HIV have increased overall mortality and death due to infections, liver diseases and non-liver neoplasms as compared to those uninfected with HCV and HIV.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationBRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.27, n.5, article ID 102810, 6p, 2023
dc.identifier.doi10.1016/j.bjid.2023.102810
dc.identifier.eissn1678-4391
dc.identifier.issn1413-8670
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57436
dc.language.isoeng
dc.publisherELSEVIER BRAZILeng
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIER BRAZILeng
dc.subjectHepatitis Ceng
dc.subjectHIVeng
dc.subjectMortalityeng
dc.subject.otherhepatitis-c viruseng
dc.subject.othercause-specific mortalityeng
dc.subject.otherall-causeeng
dc.subject.otherinfectioneng
dc.subject.otherdeatheng
dc.subject.otherlivereng
dc.subject.otherindividualseng
dc.subject.othertrendseng
dc.subject.otherrateseng
dc.subject.wosInfectious Diseaseseng
dc.titleSurvival analysis over a 20-year period of a Brazilian cohort of blood donors coinfected HIV-HCVeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalGRANDI, Giuliano:Univ Fed Sao Paulo, Med Sch, Sao Paulo, SP, Brazil
hcfmusp.author.externalCARDOSO, Ludimila Paula Vaz:Univ Fed Jatai, Dept Hlth Sci, Jatai, GO, Brazil
hcfmusp.author.externalSILVA, Juan Felipe Galvao da:Univ Fed Jatai, Dept Hlth Sci, Jatai, GO, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcHELIO RANES DE MENEZES FILHO
hcfmusp.contributor.author-fmusphcSORAIA MAFRA MACHADO
hcfmusp.contributor.author-fmusphcCESAR DE ALMEIDA NETO
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.contributor.author-fmusphcMARIA CASSIA JACINTHO MENDES CORREA
hcfmusp.description.articlenumber102810
hcfmusp.description.issue5
hcfmusp.description.volume27
hcfmusp.origemWOS
hcfmusp.origem.pubmed37813358
hcfmusp.origem.scopus2-s2.0-85174051469
hcfmusp.origem.wosWOS:001098588700001
hcfmusp.publisher.cityRIO DE JANEIROeng
hcfmusp.publisher.countryBRAZILeng
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