Cannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTROTTA, Giulia
dc.contributor.authorRODRIGUEZ, Victoria
dc.contributor.authorQUATTRONE, Diego
dc.contributor.authorSPINAZZOLA, Edoardo
dc.contributor.authorTRIPOLI, Giada
dc.contributor.authorGAYER-ANDERSON, Charlotte
dc.contributor.authorFREEMAN, Tom P.
dc.contributor.authorJONGSMA, Hannah E.
dc.contributor.authorSIDELI, Lucia
dc.contributor.authorAAS, Monica
dc.contributor.authorSTILO, Simona A.
dc.contributor.authorCASCIA, Caterina La
dc.contributor.authorFERRARO, Laura
dc.contributor.authorBARBERA, Daniele La
dc.contributor.authorLASALVIA, Antonio
dc.contributor.authorTOSATO, Sarah
dc.contributor.authorTARRICONE, Ilaria
dc.contributor.authorD'ANDREA, Giuseppe
dc.contributor.authorTORTELLI, Andrea
dc.contributor.authorSCHUERHOFF, Franck
dc.contributor.authorSZOEKE, Andrei
dc.contributor.authorPIGNON, Baptiste
dc.contributor.authorSELTEN, Jean-Paul
dc.contributor.authorVELTHORST, Eva
dc.contributor.authorHAAN, Lieuwe de
dc.contributor.authorLLORCA, Pierre-Michel
dc.contributor.authorMENEZES, Paulo Rossi
dc.contributor.authorBEN, Cristina M. Del
dc.contributor.authorSANTOS, Jose Luis
dc.contributor.authorARROJO, Manuel
dc.contributor.authorBOBES, Julio
dc.contributor.authorSANJUAN, Julio
dc.contributor.authorBERNARDO, Miquel
dc.contributor.authorARANGO, Celso
dc.contributor.authorKIRKBRIDE, James B.
dc.contributor.authorJONES, Peter B.
dc.contributor.authorRICHARDS, Alexander
dc.contributor.authorRUTTEN, Bart P.
dc.contributor.authorOS, Jim Van
dc.contributor.authorAUSTIN-ZIMMERMAN, Isabelle
dc.contributor.authorLI, Zhikun
dc.contributor.authorMORGAN, Craig
dc.contributor.authorSHAM, Pak C.
dc.contributor.authorVASSOS, Evangelos
dc.contributor.authorWONG, Chloe
dc.contributor.authorBENTALL, Richard
dc.contributor.authorFISHER, Helen L.
dc.contributor.authorMURRAY, Robin M.
dc.contributor.authorALAMEDA, Luis
dc.contributor.authorFORTI, Marta Di
dc.contributor.groupauthorEU GEI WP2 Grp
dc.date.accessioned2024-04-05T19:34:28Z
dc.date.available2024-04-05T19:34:28Z
dc.date.issued2023
dc.description.abstractBackgroundChildhood adversity and cannabis use are considered independent risk factors for psychosis, but whether different patterns of cannabis use may be acting as mediator between adversity and psychotic disorders has not yet been explored. The aim of this study is to examine whether cannabis use mediates the relationship between childhood adversity and psychosis. MethodsData were utilised on 881 first-episode psychosis patients and 1231 controls from the European network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Detailed history of cannabis use was collected with the Cannabis Experience Questionnaire. The Childhood Experience of Care and Abuse Questionnaire was used to assess exposure to household discord, sexual, physical or emotional abuse and bullying in two periods: early (0-11 years), and late (12-17 years). A path decomposition method was used to analyse whether the association between childhood adversity and psychosis was mediated by (1) lifetime cannabis use, (2) cannabis potency and (3) frequency of use. ResultsThe association between household discord and psychosis was partially mediated by lifetime use of cannabis (indirect effect coef. 0.078, s.e. 0.022, 17%), its potency (indirect effect coef. 0.059, s.e. 0.018, 14%) and by frequency (indirect effect coef. 0.117, s.e. 0.038, 29%). Similar findings were obtained when analyses were restricted to early exposure to household discord. ConclusionsHarmful patterns of cannabis use mediated the association between specific childhood adversities, like household discord, with later psychosis. Children exposed to particularly challenging environments in their household could benefit from psychosocial interventions aimed at preventing cannabis misuse.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.identifier.citationPSYCHOLOGICAL MEDICINE, v.53, n.15, p.7375-7384, 2023
dc.identifier.doi10.1017/S0033291723000995
dc.identifier.eissn1469-8978
dc.identifier.issn0033-2917
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58974
dc.language.isoeng
dc.publisherCAMBRIDGE UNIV PRESSeng
dc.relation.ispartofPsychological Medicine
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright CAMBRIDGE UNIV PRESSeng
dc.subjectCannabis useeng
dc.subjectchildhood experienceeng
dc.subjectmediationeng
dc.subjectpsychotic disorderseng
dc.subjecttraumaeng
dc.subject.othersexual-abuseeng
dc.subject.otherriskeng
dc.subject.othertraumaeng
dc.subject.otherassociationeng
dc.subject.othersymptomseng
dc.subject.othermetaanalysiseng
dc.subject.otherexperienceseng
dc.subject.otherdisorderseng
dc.subject.otherincreaseeng
dc.subject.otherimpacteng
dc.subject.wosPsychology, Clinicaleng
dc.subject.wosPsychiatryeng
dc.subject.wosPsychologyeng
dc.titleCannabis use as a potential mediator between childhood adversity and first-episode psychosis: results from the EU-GEI case-control studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryPaís de Gales
hcfmusp.affiliation.countryHolanda
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryChina
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisonl
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisocn
hcfmusp.author.externalTROTTA, Giulia:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.author.externalRODRIGUEZ, Victoria:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
hcfmusp.author.externalQUATTRONE, Diego:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.author.externalSPINAZZOLA, Edoardo:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
hcfmusp.author.externalTRIPOLI, Giada:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
hcfmusp.author.externalGAYER-ANDERSON, Charlotte:Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res, London, England
hcfmusp.author.externalFREEMAN, Tom P.:Univ Bath, Dept Pharm & Pharmacol, Bath, Avon, England; Univ Bath, Dept Life Sci, Bath, Avon, England
hcfmusp.author.externalJONGSMA, Hannah E.:UCL, Div Psychiat, PsyLife Grp, London, England
hcfmusp.author.externalSIDELI, Lucia:LUMSA Univ, Dept Human Sci, Rome, Italy
hcfmusp.author.externalAAS, Monica:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.author.externalSTILO, Simona A.:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
hcfmusp.author.externalCASCIA, Caterina La:Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy
hcfmusp.author.externalFERRARO, Laura:Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy
hcfmusp.author.externalBARBERA, Daniele La:Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy
hcfmusp.author.externalLASALVIA, Antonio:Univ Verona, Sect Psychiat, Dept Neurosci Biomed & Movement, Verona, Italy
hcfmusp.author.externalTOSATO, Sarah:Univ Verona, Sect Psychiat, Dept Neurosci Biomed & Movement, Verona, Italy
hcfmusp.author.externalTARRICONE, Ilaria:Univ Bologna, Dept Med & Surg Sci, Bologna, Italy
hcfmusp.author.externalD'ANDREA, Giuseppe:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
hcfmusp.author.externalTORTELLI, Andrea:Estab Publ Sante, Maison Blanche, France
hcfmusp.author.externalSCHUERHOFF, Franck:Univ Paris Est Creteil UPEC, Hopitaux Univ H Mondor, AP HP,Fdn FondaMental, DMU,IMPACT,INSERM,IMRB,Translat Neuropsychiat, F-94010 Creteil, France
hcfmusp.author.externalSZOEKE, Andrei:Univ Paris Est Creteil UPEC, Hopitaux Univ H Mondor, AP HP,Fdn FondaMental, DMU,IMPACT,INSERM,IMRB,Translat Neuropsychiat, F-94010 Creteil, France
hcfmusp.author.externalPIGNON, Baptiste:Univ Paris Est Creteil UPEC, Hopitaux Univ H Mondor, AP HP,Fdn FondaMental, DMU,IMPACT,INSERM,IMRB,Translat Neuropsychiat, F-94010 Creteil, France
hcfmusp.author.externalSELTEN, Jean-Paul:GGZ Rivierduinen, Inst Mental Hlth, Leiden, Netherlands
hcfmusp.author.externalVELTHORST, Eva:Mt Sinai Sch Med, Dept Psychiat, Icahn Sch Med, New York, NY USA
hcfmusp.author.externalHAAN, Lieuwe de:Amsterdam UMC, Early Psychosis Sect, Dept Psychiat, Amsterdam, Netherlands
hcfmusp.author.externalLLORCA, Pierre-Michel:Univ Clermont Auvergne, EA 7280 Npsydo, Clermont Ferrand, France
hcfmusp.author.externalBEN, Cristina M. Del:Univ Sao Paulo, Ribeirao Preto Med Sch, Div Psychiat, Dept Neurosci & Behav, Sao Paulo, Brazil
hcfmusp.author.externalSANTOS, Jose Luis:Hosp Virgen de la Luz, Dept Psychiat, Cuenca, Spain
hcfmusp.author.externalARROJO, Manuel:Complejo Hosp Univ Santiago de Compostela, Inst Invest Sanitaria Santiago de Compostela, Dept Psychiat, Psychiat Genet Grp, Santiago De Compostela, Spain
hcfmusp.author.externalBOBES, Julio:Univ Oviedo, Dept Med, Psychiat Area, ISPA,INEUROPA,CIBERSAM, Oviedo, Spain
hcfmusp.author.externalSANJUAN, Julio:Univ Valencia, Sch Med, Ctr Invest Biomed Red Salud Mental, Dept Psychiat, Valencia, Spain
hcfmusp.author.externalBERNARDO, Miquel:Univ Barcelona, Ctr Invest Biomed Red Salud Mental, Inst Invest Biomed August Pi & Sunyer,Neurosci In, Barcelona Clin Schizophrenia Unit,Hosp Clin,Dept, Barcelona, Spain
hcfmusp.author.externalARANGO, Celso:Univ Complutense, Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat,Sch Med,ISGM,CIB, Madrid, Spain
hcfmusp.author.externalKIRKBRIDE, James B.:UCL, Div Psychiat, PsyLife Grp, London, England
hcfmusp.author.externalJONES, Peter B.:Cambridgeshire & Peterborough Natl Hlth Serv Fdn, CAMEO Early Intervent Serv, Cambridge, England
hcfmusp.author.externalRICHARDS, Alexander:Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Div Psychol Med & Clin Neurosci, Cardiff, Wales
hcfmusp.author.externalRUTTEN, Bart P.:Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
hcfmusp.author.externalOS, Jim Van:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
hcfmusp.author.externalAUSTIN-ZIMMERMAN, Isabelle:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.author.externalLI, Zhikun:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.author.externalMORGAN, Craig:Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res, London, England
hcfmusp.author.externalSHAM, Pak C.:Univ Hong Kong, Hong Kong, Peoples R China; Univ Hong Kong, Hong Kong, Peoples R China
hcfmusp.author.externalVASSOS, Evangelos:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.author.externalWONG, Chloe:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.author.externalBENTALL, Richard:Univ Sheffield, Dept Psychol, Sheffield, S Yorkshire, England
hcfmusp.author.externalFISHER, Helen L.:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.author.externalMURRAY, Robin M.:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
hcfmusp.author.externalALAMEDA, Luis:Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
hcfmusp.author.externalFORTI, Marta Di:Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcPAULO ROSSI MENEZES
hcfmusp.description.articlenumberPII S0033291723000995
hcfmusp.description.beginpage7375
hcfmusp.description.endpage7384
hcfmusp.description.issue15
hcfmusp.description.volume53
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1157795371
hcfmusp.origem.pubmed38078747
hcfmusp.origem.scopus2-s2.0-85179647128
hcfmusp.origem.wosWOS:000992563200001
hcfmusp.publisher.cityCAMBRIDGEeng
hcfmusp.publisher.countryENGLANDeng
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