Time-dependent vaccine efficacy estimation quantified by a mathematical model
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Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
PUBLIC LIBRARY SCIENCE
Autores
LORIA, Jennifer
ALBANI, Vinicius V. L.
COVAS, Dimas T.
STRUCHINER, Claudio J.
ZUBELLI, Jorge P.
Citação
PLOS ONE, v.18, n.5, article ID e0285466, 18p, 2023
Resumo
In this paper we calculate the variation of the estimated vaccine efficacy (VE) due to the time-dependent force of infection resulting from the difference between the moment the Clinical Trial (CT) begins and the peak in the outbreak intensity. Using a simple mathematical model we tested the hypothesis that the time difference between the moment the CT begins and the peak in the outbreak intensity determines substantially different values for VE. We exemplify the method with the case of the VE efficacy estimation for one of the vaccines against the new coronavirus SARS-CoV-2.
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Referências
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