Local and remote ischemic preconditioning protect against intestinal ischemic/reperfusion injury after supraceliac aortic clamping

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorERLING JUNIOR, Nilon
dc.contributor.authorMONTERO, Edna Frasson de Souza
dc.contributor.authorSANNOMIYA, Paulina
dc.contributor.authorPOLI-DE-FIGUEIREDO, Luiz Francisco
dc.date.accessioned2014-04-25T21:49:50Z
dc.date.available2014-04-25T21:49:50Z
dc.date.issued2013
dc.description.abstractOBJECTIVES: This study tests the hypothesis that local or remote ischemic preconditioning may protect the intestinal mucosa against ischemia and reperfusion injuries resulting from temporary supraceliac aortic clamping. METHODS: Twenty-eight Wistar rats were divided into four groups: the sham surgery group, the supraceliac aortic occlusion group, the local ischemic preconditioning prior to supraceliac aortic occlusion group, and the remote ischemic preconditioning prior to supraceliac aortic occlusion group. Tissue samples from the small bowel were used for quantitative morphometric analysis of mucosal injury, and blood samples were collected for laboratory analyses. RESULTS: Supraceliac aortic occlusion decreased intestinal mucosal length by reducing villous height and elevated serum lactic dehydrogenase and lactate levels. Both local and remote ischemic preconditioning mitigated these histopathological and laboratory changes. CONCLUSIONS: Both local and remote ischemic preconditioning protect intestinal mucosa against ischemia and reperfusion injury following supraceliac aortic clamping.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [04/15964-6]
dc.identifier.citationCLINICS, v.68, n.12, p.1548-1554, 2013
dc.identifier.doi10.6061/clinics/2013(12)12
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5048
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartofClinics
dc.rightsopenAccess
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.subjectAorta
dc.subjectReperfusion
dc.subjectIschemic Preconditioning
dc.subjectIntestinal Mucosa
dc.subjectRats
dc.subject.otherrandomized controlled-trial
dc.subject.otherreperfusion injury
dc.subject.othervisceral ischemia
dc.subject.othermucosal injury
dc.subject.otherorgan injury
dc.subject.otherrat model
dc.subject.otherinterleukin-10
dc.subject.otherpreservation
dc.subject.othermyocardium
dc.subject.othermechanisms
dc.subject.wosMedicine, General & Internal
dc.titleLocal and remote ischemic preconditioning protect against intestinal ischemic/reperfusion injury after supraceliac aortic clamping
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalERLING JUNIOR, Nilon:Univ Fed Ciencias Saude Porto Alegre, Dept Surg, Porto Alegre, RS, Brazil
hcfmusp.citation.scopus26
hcfmusp.contributor.author-fmusphcEDNA FRASSON DE SOUZA MONTERO
hcfmusp.contributor.author-fmusphcPAULINA SANNOMIYA
hcfmusp.contributor.author-fmusphcLUIZ FRANCISCO POLI DE FIGUEIREDO
hcfmusp.description.beginpage1548
hcfmusp.description.endpage1554
hcfmusp.description.issue12
hcfmusp.description.volume68
hcfmusp.origemWOS
hcfmusp.origem.pubmed24473514
hcfmusp.origem.scieloSCIELO:S1807-59322013001201548
hcfmusp.origem.scopus2-s2.0-84892741774
hcfmusp.origem.wosWOS:000329985900012
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
hcfmusp.relation.referenceAbrahao MS, 2004, TRANSPLANT P, V36, P860, DOI 10.1016/j.transproceed.2004.03.046
hcfmusp.relation.referenceAli ZA, 2007, CIRCULATION S, V116, P98, DOI 10.1161/CIRCULATIONAHA.106.679167
hcfmusp.relation.referenceBack MR, 2005, ANN VASC SURG, V19, P648, DOI 10.1007/s10016-005-6843-3
hcfmusp.relation.referenceBolli R, 2007, AM J PHYSIOL-HEART C, V292, pH19, DOI 10.1152/ajpheart.00712.2006
hcfmusp.relation.referenceBotker HE, 2010, LANCET, V375, P727, DOI 10.1016/S0140-6736(09)62001-8
hcfmusp.relation.referenceCheung MMH, 2006, J AM COLL CARDIOL, V47, P2277, DOI 10.1016/j.jacc.2006.01.066
hcfmusp.relation.referenceCornet AD, 2009, J SURG RES, V157, P48, DOI 10.1016/j.jss.2008.09.021
hcfmusp.relation.referencede Arruda Marcio Jose Cristiano, 2006, Clinics (Sao Paulo), V61, P21, DOI 10.1590/S1807-59322006000100005
hcfmusp.relation.referencedeFigueiredo LFP, 1997, SURGERY, V122, P32
hcfmusp.relation.referenceDeSesso JM, 2001, FOOD CHEM TOXICOL, V39, P209, DOI 10.1016/S0278-6915(00)00136-8
hcfmusp.relation.referenceDowney JM, 2007, HEART FAIL REV, V12, P181, DOI 10.1007/s10741-007-9025-2
hcfmusp.relation.referenceEide TO, 2005, EUR SURG RES, V37, P330, DOI 10.1159/000090332
hcfmusp.relation.referenceEltzschig HK, 2011, NAT MED, V17, P1391, DOI 10.1038/nm.2507
hcfmusp.relation.referenceErling N, 2010, J VASC SURG, V52, P1321, DOI 10.1016/j.jvs.2010.05.120
hcfmusp.relation.referenceHarkin DW, 2001, ANN VASC SURG, V15, P326, DOI 10.1007/s100160010087
hcfmusp.relation.referenceHausenloy DJ, 2007, LANCET, V370, P575, DOI 10.1016/S0140-6736(07)61296-3
hcfmusp.relation.referenceHess PJ, 1997, J VASC SURG, V26, P113, DOI 10.1016/S0741-5214(97)70154-X
hcfmusp.relation.referenceHiga OH, 2007, CLINICS, V62, P315, DOI 10.1590/S1807-59322007000300017
hcfmusp.relation.referenceHoole SP, 2009, CIRCULATION, V119, P820, DOI 10.1161/CIRCULATIONAHA.108.809723
hcfmusp.relation.referenceHotter G, 1996, BIOCHEM BIOPH RES CO, V222, P27, DOI 10.1006/bbrc.1996.0692
hcfmusp.relation.referenceJaeschke H, 2003, AM J PHYSIOL-GASTR L, V284, pG15, DOI 10.1152/ajpgi.00342.2002
hcfmusp.relation.referenceKanoria S, 2007, TRANSPLANTATION, V84, P445, DOI 10.1097/01.tp.0000228235.55419.e8
hcfmusp.relation.referenceMallick IH, 2005, BRIT J SURG, V92, P1169, DOI 10.1002/bjs.4988
hcfmusp.relation.referenceMallick IH, 2004, DIGEST DIS SCI, V49, P1359, DOI 10.1023/B:DDAS.0000042232.98927.91
hcfmusp.relation.referenceMoore-Olufemi SD, 2005, SHOCK, V23, P258, DOI 10.1097/01.shk.0000155195.17687.00
hcfmusp.relation.referenceMURRY CE, 1986, CIRCULATION, V74, P1124
hcfmusp.relation.referenceNeves JD, 2011, ACTA CIR BRAS, V26, P396, DOI 10.1590/S0102-86502011000500013
hcfmusp.relation.referencePasupathy S, 2005, ARCH SURG-CHICAGO, V140, P405, DOI 10.1001/archsurg.140.4.405
hcfmusp.relation.referencePasupathy S, 2005, EUR J VASC ENDOVASC, V29, P106, DOI 10.1016/j.ejvs.2004.11.005
hcfmusp.relation.referencePRZYKLENK K, 1993, CIRCULATION, V87, P893
hcfmusp.relation.referenceSola A, 2001, ANN SURG, V234, P98, DOI 10.1097/00000658-200107000-00015
hcfmusp.relation.referenceTamion F, 2002, AM J PHYSIOL-GASTR L, V283, pG408, DOI 10.1152/ajpgi.00348.2001
hcfmusp.relation.referenceTapuria N, 2008, J SURG RES, V150, P304, DOI 10.1016/j.jss.2007.12.747
hcfmusp.relation.referenceVlasov T D, 2002, Neurosci Behav Physiol, V32, P449, DOI 10.1023/A:1015896614819
hcfmusp.relation.referenceWalsh SR, 2009, J ENDOVASC THER, V16, P680, DOI 10.1583/09-2817.1
hcfmusp.relation.referenceWelborn MB, 2003, SHOCK, V20, P35, DOI 10.1097/01.SHK.0000071062.67193.b6
hcfmusp.relation.referenceWelborn MB, 1996, SHOCK, V6, P171, DOI 10.1097/00024382-199609010-00003
hcfmusp.relation.referenceWu B, 2004, AM J PHYSIOL-GASTR L, V286, pG580, DOI 10.1152/ajpgi.00335.2003
hcfmusp.relation.referenceZanoni FL, 2009, CLINICS, V64, P911, DOI 10.1590/S1807-59322009000900013
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