Increased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGOYA, Thiago T.
dc.contributor.authorSILVA, Rosyvaldo F.
dc.contributor.authorGUERRA, Renan S.
dc.contributor.authorLIMA, Marta F.
dc.contributor.authorBARBOSA, Eline R. F.
dc.contributor.authorCUNHA, Paulo Jannuzzi
dc.contributor.authorLOBO, Denise M. L.
dc.contributor.authorBUCHPIGUEL, Carlos A.
dc.contributor.authorBUSATTO-FILHO, Geraldo
dc.contributor.authorNEGRAO, Carlos E.
dc.contributor.authorLORENZI-FILHO, Geraldo
dc.contributor.authorUENO-PARDI, Linda M.
dc.date.accessioned2016-03-14T14:23:23Z
dc.date.available2016-03-14T14:23:23Z
dc.date.issued2016
dc.description.abstractStudy Objectives: To investigate muscle sympathetic nerve activity (MSNA) response and executive performance during mental stress in obstructive sleep apnea (OSA). Methods: Individuals with no other comorbidities (age = 52 +/- 1 y, body mass index = 29 +/- 0.4, kg/m(2)) were divided into two groups: (1) control (n = 15) and (2) untreated OSA (n = 20) defined by polysomnography. Mini-Mental State of Examination (MMSE) and Inteligence quocient (IQ) were assessed. Heart rate (HR), blood pressure (BP), and MSNA (microneurography) were measured at baseline and during 3 min of the Stroop Color Word Test (SCWT). Sustained attention and inhibitory control were assessed by the number of correct answers and errors during SCWT. Results: Control and OSA groups (apnea-hypopnea index, AHI = 8 +/- 1 and 47 +/- 1 events/h, respectively) were similar in age, MMSE, and IQ. Baseline HR and BP were similar and increased similarly during SCWT in control and OSA groups. In contrast, baseline MSNA was higher in OSA compared to controls. Moreover, MSNA significantly increased in the third minute of SCWT in OSA, but remained unchanged in controls (P < 0.05). The number of correct answers was lower and the number of errors was significantly higher during the second and third minutes of SCWT in the OSA group (P < 0.05). There was a significant correlation (P < 0.01) between the number of errors in the third minute of SCWT with AHI (r = 0.59), arousal index (r = 0.55), and minimum O-2 saturation (r = -0.57). Conclusions: As compared to controls, MSNA is increased in patients with OSA at rest, and further significant MSNA increments and worse executive performance are seen during mental stress.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2010/15064-6]
dc.description.sponsorshipPro-Reitoria de Pesquisa da Universidade de Sao Paulo
dc.identifier.citationSLEEP, v.39, n.1, p.25-33, 2016
dc.identifier.doi10.5665/sleep.5310
dc.identifier.eissn1550-9109
dc.identifier.issn0161-8105
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/13423
dc.language.isoeng
dc.publisherAMER ACAD SLEEP MEDICINE
dc.relation.ispartofSleep
dc.rightsrestrictedAccess
dc.rights.holderCopyright AMER ACAD SLEEP MEDICINE
dc.subjectexecutive performance
dc.subjectmental stress
dc.subjectmuscle sympathetic nerve activity
dc.subjectobstructive sleep apnea
dc.subject.otheradvanced heart-failure
dc.subject.otheracute mental stress
dc.subject.otherblood-pressure
dc.subject.othercardiovascular-responses
dc.subject.otherneurovascular responses
dc.subject.otherobese women
dc.subject.otherhypertension
dc.subject.otherhumans
dc.subject.otherrisk
dc.subject.othertask
dc.subject.wosClinical Neurology
dc.subject.wosNeurosciences
dc.titleIncreased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSILVA, Rosyvaldo F.:Univ Sao Paulo, Escola Artes Ciencias & Humanidades, BR-03828000 Sao Paulo, Brazil
hcfmusp.author.externalBARBOSA, Eline R. F.:InCor HCFMUSP, Sao Paulo, Brazil
hcfmusp.author.externalUENO-PARDI, Linda M.:Univ Sao Paulo, Escola Artes Ciencias & Humanidades, BR-03828000 Sao Paulo, Brazil; Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-03828000 Sao Paulo, Brazil
hcfmusp.citation.scopus32
hcfmusp.contributor.author-fmusphcTHIAGO TANAKA GOYA
hcfmusp.contributor.author-fmusphcRENAN SEGALLA GUERRA
hcfmusp.contributor.author-fmusphcMARTA FERNANDES LIMA
hcfmusp.contributor.author-fmusphcPAULO JANNUZZI CUNHA
hcfmusp.contributor.author-fmusphcDENISE MOREIRA LIMA LOBO
hcfmusp.contributor.author-fmusphcCARLOS ALBERTO BUCHPIGUEL
hcfmusp.contributor.author-fmusphcGERALDO BUSATTO FILHO
hcfmusp.contributor.author-fmusphcCARLOS EDUARDO NEGRAO
hcfmusp.contributor.author-fmusphcGERALDO LORENZI FILHO
hcfmusp.description.beginpage25
hcfmusp.description.endpage33
hcfmusp.description.issue1
hcfmusp.description.volume39
hcfmusp.origemWOS
hcfmusp.origem.pubmed26237773
hcfmusp.origem.scopus2-s2.0-84957076399
hcfmusp.origem.wosWOS:000367515700007
hcfmusp.publisher.cityWESTCHESTER
hcfmusp.publisher.countryUSA
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