The role of intratumoral lymphovascular density in distinguishing primary from secondary mucinous ovarian tumors

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorALMEIDA, Bernardo Gomes de Lacerda
dc.contributor.authorBACCHI, Carlos E.
dc.contributor.authorCARVALHO, Jesus P.
dc.contributor.authorFERREIRA, Cristiane R.
dc.contributor.authorCARVALHO, Filomena M.
dc.date.accessioned2015-04-22T22:14:06Z
dc.date.available2015-04-22T22:14:06Z
dc.date.issued2014
dc.description.abstractOBJECTIVE: Ovarian mucinous metastases commonly present as the first sign of the disease and are capable of simulating primary tumors. Our aim was to investigate the role of intratumoral lymphatic vascular density together with other surgical-pathological features in distinguishing primary from secondary mucinous ovarian tumors. METHODS: A total of 124 cases of mucinous tumors in the ovary (63 primary and 61 metastatic) were compared according to their clinicopathological features and immunohistochemical profiles. The intratumoral lymphatic vascular density was quantified by counting the number of vessels stained by the D2-40 antibody. RESULTS: Metastases occurred in older patients and were associated with a higher proportion of tumors smaller than 10.0 cm; bilaterality; extensive necrosis; extraovarian extension; increased expression of cytokeratin 20, CDX2, CA19.9 and MUC2; and decreased expression of cytokeratin 7, CA125 and MUC5AC. The lymphatic vascular density was increased among primary tumors. However, after multivariate analysis, the best predictors of a secondary tumor were a size of 10.0 cm or less, bilaterality and cytokeratin 7 negativity. Lack of MUC2 expression was an important factor excluding metastasis. CONCLUSIONS: The higher intratumoral lymphatic vascular density in primary tumors when compared with secondary lesions suggests differences in the microenvironment. However, considering the differential diagnosis, the best discriminator of a secondary tumor is the combination of tumor size, laterality and the pattern of expression of cytokeratin 7 and MUC2.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP - Sao Paulo Research Foundation [2012/11833-0]
dc.identifier.citationCLINICS, v.69, n.10, p.660-665, 2014
dc.identifier.doi10.6061/clinics/2014(10)02
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9023
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartofClinics
dc.rightsopenAccess
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.subjectMucinous Ovarian Tumors
dc.subjectOvarian Metastasis
dc.subjectLymphatic Vascular Density
dc.subjectD2-40
dc.subjectImmunohistochemistry
dc.subject.otherlymphatic vessel density
dc.subject.othernode metastases
dc.subject.othercarcinomas
dc.subject.othercancer
dc.subject.otherdistinction
dc.subject.otherexpression
dc.subject.otherneoplasms
dc.subject.otherlymphangiogenesis
dc.subject.othercytokeratin-20
dc.subject.otherclassification
dc.subject.wosMedicine, General & Internal
dc.titleThe role of intratumoral lymphovascular density in distinguishing primary from secondary mucinous ovarian tumors
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBACCHI, Carlos E.:Botucatu Consultoria Patol, Lab Bacchi, Botucatu, SP, Brazil
hcfmusp.author.externalFERREIRA, Cristiane R.:Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcBERNARDO GOMES DE LACERDA ALMEIDA
hcfmusp.contributor.author-fmusphcJESUS PAULA CARVALHO
hcfmusp.contributor.author-fmusphcFILOMENA MARINO CARVALHO
hcfmusp.description.beginpage660
hcfmusp.description.endpage665
hcfmusp.description.issue10
hcfmusp.description.volume69
hcfmusp.origemWOS
hcfmusp.origem.pubmed25518016
hcfmusp.origem.scieloSCIELO:S1807-59322014001000660
hcfmusp.origem.scopus2-s2.0-84920381010
hcfmusp.origem.wosWOS:000346073000002
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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