The role of IFN-gamma production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | CORDEIRO, Patricia Azevedo Soares | |
dc.contributor.author | ASSONE, Tatiane | |
dc.contributor.author | PRATES, Gabriela | |
dc.contributor.author | TEDESCHI, Marcia Regina Martinez | |
dc.contributor.author | FONSECA, Luiz Augusto Marcondes | |
dc.contributor.author | CASSEB, Jorge | |
dc.date.accessioned | 2022-12-21T13:21:15Z | |
dc.date.available | 2022-12-21T13:21:15Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Interferon-gamma (IFN-gamma) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-gamma in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-gamma during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health. | eng |
dc.description.index | MEDLINE | eng |
dc.identifier.citation | REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.64, article ID e64, 9p, 2022 | |
dc.identifier.doi | 10.1590/S1678-9946202264064 | |
dc.identifier.eissn | 1678-9946 | |
dc.identifier.issn | 0036-4665 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/50491 | |
dc.language.iso | eng | |
dc.publisher | INST MEDICINA TROPICAL SAO PAULO | eng |
dc.relation.ispartof | Revista do Instituto de Medicina Tropical de Sao Paulo | |
dc.rights | openAccess | eng |
dc.rights.holder | Copyright INST MEDICINA TROPICAL SAO PAULO | eng |
dc.subject | Retroviruses | eng |
dc.subject | HIV | eng |
dc.subject | HTLV-1 | eng |
dc.subject | HERVs | eng |
dc.subject | Interferon-gamma | eng |
dc.subject | Immune regulation | eng |
dc.subject.other | human endogenous retroviruses | eng |
dc.subject.other | multiple-sclerosis | eng |
dc.subject.other | interferon-gamma | eng |
dc.subject.other | htlv-1 infection | eng |
dc.subject.other | hiv-infection | eng |
dc.subject.other | expression | eng |
dc.subject.other | alpha | eng |
dc.subject.other | mechanisms | eng |
dc.subject.other | elements | eng |
dc.subject.other | ham/tsp | eng |
dc.subject.wos | Infectious Diseases | eng |
dc.subject.wos | Parasitology | eng |
dc.subject.wos | Tropical Medicine | eng |
dc.title | The role of IFN-gamma production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis | eng |
dc.type | article | eng |
dc.type.category | review | eng |
dc.type.version | publishedVersion | eng |
dspace.entity.type | Publication | |
hcfmusp.author.external | TEDESCHI, Marcia Regina Martinez:Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Invest Dermatol & Imunodeficiencias LIM 56, Fac Med, Sao Paulo, SP, Brazil | |
hcfmusp.citation.scopus | 3 | |
hcfmusp.contributor.author-fmusphc | PATRICIA AZEVEDO SOARES CORDEIRO | |
hcfmusp.contributor.author-fmusphc | TATIANE ASSONE CASSEB | |
hcfmusp.contributor.author-fmusphc | GABRIELA DA SILVA PRATES | |
hcfmusp.contributor.author-fmusphc | LUIZ AUGUSTO MARCONDES FONSECA | |
hcfmusp.contributor.author-fmusphc | JORGE SIMAO DO ROSARIO CASSEB | |
hcfmusp.description.articlenumber | e64 | |
hcfmusp.description.volume | 64 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 36197425 | |
hcfmusp.origem.scielo | SCIELO:S0036-46652022000100404 | |
hcfmusp.origem.scopus | 2-s2.0-85139124654 | |
hcfmusp.origem.wos | WOS:000874034100008 | |
hcfmusp.publisher.city | SAO PAULO | eng |
hcfmusp.publisher.country | BRAZIL | eng |
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hcfmusp.scopus.lastupdate | 2024-05-17 | |
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