The role of IFN-gamma production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCORDEIRO, Patricia Azevedo Soares
dc.contributor.authorASSONE, Tatiane
dc.contributor.authorPRATES, Gabriela
dc.contributor.authorTEDESCHI, Marcia Regina Martinez
dc.contributor.authorFONSECA, Luiz Augusto Marcondes
dc.contributor.authorCASSEB, Jorge
dc.date.accessioned2022-12-21T13:21:15Z
dc.date.available2022-12-21T13:21:15Z
dc.date.issued2022
dc.description.abstractInterferon-gamma (IFN-gamma) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-gamma in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-gamma during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.eng
dc.description.indexMEDLINEeng
dc.identifier.citationREVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.64, article ID e64, 9p, 2022
dc.identifier.doi10.1590/S1678-9946202264064
dc.identifier.eissn1678-9946
dc.identifier.issn0036-4665
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/50491
dc.language.isoeng
dc.publisherINST MEDICINA TROPICAL SAO PAULOeng
dc.relation.ispartofRevista do Instituto de Medicina Tropical de Sao Paulo
dc.rightsopenAccesseng
dc.rights.holderCopyright INST MEDICINA TROPICAL SAO PAULOeng
dc.subjectRetroviruseseng
dc.subjectHIVeng
dc.subjectHTLV-1eng
dc.subjectHERVseng
dc.subjectInterferon-gammaeng
dc.subjectImmune regulationeng
dc.subject.otherhuman endogenous retroviruseseng
dc.subject.othermultiple-sclerosiseng
dc.subject.otherinterferon-gammaeng
dc.subject.otherhtlv-1 infectioneng
dc.subject.otherhiv-infectioneng
dc.subject.otherexpressioneng
dc.subject.otheralphaeng
dc.subject.othermechanismseng
dc.subject.otherelementseng
dc.subject.otherham/tspeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosParasitologyeng
dc.subject.wosTropical Medicineeng
dc.titleThe role of IFN-gamma production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesiseng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalTEDESCHI, Marcia Regina Martinez:Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Invest Dermatol & Imunodeficiencias LIM 56, Fac Med, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcPATRICIA AZEVEDO SOARES CORDEIRO
hcfmusp.contributor.author-fmusphcTATIANE ASSONE CASSEB
hcfmusp.contributor.author-fmusphcGABRIELA DA SILVA PRATES
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO MARCONDES FONSECA
hcfmusp.contributor.author-fmusphcJORGE SIMAO DO ROSARIO CASSEB
hcfmusp.description.articlenumbere64
hcfmusp.description.volume64
hcfmusp.origemWOS
hcfmusp.origem.pubmed36197425
hcfmusp.origem.scieloSCIELO:S0036-46652022000100404
hcfmusp.origem.scopus2-s2.0-85139124654
hcfmusp.origem.wosWOS:000874034100008
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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