Effect of adding clonidine to lidocaine on ocular hemodynamics during sub-Tenon’s anesthesia: randomized double-blind study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCABRAL, Sigmar Aurea
dc.contributor.authorCARRARETTO, Antonio Roberto
dc.contributor.authorSOUSA, Angela Maria
dc.contributor.authorGOMEZ, Renato Santiago
dc.date.accessioned2022-03-09T17:57:15Z
dc.date.available2022-03-09T17:57:15Z
dc.date.issued2021
dc.description.abstractAbstract Introduction and objectives Different regional anesthesia techniques for ophthalmology can have hemodynamic effects on the eye. We assessed the effects of adding clonidine to lidocaine on Intraocular Pressure (IOP), Ocular Pulse Amplitude (OPA), and Ocular Perfusion Pressure (OPP) after the sub-Tenon’s technique for cataract surgery. Methods The study included 40 patients randomly allocated into two groups: sub-Tenon’s blockade with Lidocaine plus Saline Solution (LS) or Lidocaine plus Clonidine (LC). IOP, OPA and OPP were measured before anesthesia, and 1, 5 and 10 minutes after the injection of anesthetic solution. Results There was no difference between the groups in IOP, OPA, and OPP baseline values. After the injection of the anesthetic solution, the IOP increased in both groups at minute one, with a mean difference of +4.67 mmHg (p= 0.001) and +2.15 mmHg (p= 0.013) at 5 minutes. The increase was lower in the LC group when compared to LS (p= 0.027). OPA decreased in both groups, with a baseline difference, after 1 minute, of -0.85 mmHg (p = -0.85 mmHg (p= 0.001), and at 5 and 10 minutes with differences of -1.17 (p= 0.001) and -0.89 mmHg (p= 0.001), respectively. The highest decrease was observed in group LC in relation to group LS (p= 0.03). There was no difference in OPP in relation to baseline measurements. Conclusions Adding clonidine to lidocaine for sub-Tenon’s anesthesia reduced IOP and OPA without significant changes in OPP.eng
dc.description.indexWoSeng
dc.identifier.citationBRAZILIAN JOURNAL OF ANESTHESIOLOGY, v.71, n.6, p.628-634, 2021
dc.identifier.doi10.1016/j.bjane.2021.08.004
dc.identifier.issn2352-2291
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44864
dc.language.isoengpor
dc.publisherSociedade Brasileira de Anestesiologia (SBA)eng
dc.relation.ispartofBrazilian Journal of Anesthesiology
dc.rightsopenAccesseng
dc.rights.holderCopyright Sociedade Brasileira de Anestesiologia (SBA)eng
dc.subjectSub-Tenon’s anesthesiaeng
dc.subjectClonidineeng
dc.subjectIntraocular pressureeng
dc.subjectOcular pulse amplitudeeng
dc.subjectOcular perfusion pressureeng
dc.subjectCataract surgeryeng
dc.subject.wosAnesthesiologyeng
dc.subject.wosMedicine, General & Internaleng
dc.titleEffect of adding clonidine to lidocaine on ocular hemodynamics during sub-Tenon’s anesthesia: randomized double-blind studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalCABRAL, Sigmar Aurea:Universidade Federal do Espírito Santo, Brazil
hcfmusp.author.externalCARRARETTO, Antonio Roberto:Universidade Federal do Espírito Santo, Brazil
hcfmusp.author.externalGOMEZ, Renato Santiago:Universidade Federal de Minas Gerais, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcANGELA MARIA SOUSA
hcfmusp.description.beginpage628
hcfmusp.description.endpage634
hcfmusp.description.issue6
hcfmusp.description.volume71
hcfmusp.origemWOS
hcfmusp.origem.scieloSCIELO:S2352-22912021000600628
hcfmusp.origem.scopus2-s2.0-85120322868
hcfmusp.origem.wosWOS:000750115500008
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