A pilot study assessing the effect of bronchodilator on dynamic hyperinflation in LAM

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBALDI, Bruno Guedes
dc.contributor.authorALBUQUERQUE, Andre Luis Pereira de
dc.contributor.authorPIMENTA, Suzana Pinheiro
dc.contributor.authorSALGE, Joao Marcos
dc.contributor.authorKAIRALLA, Ronaldo Adib
dc.contributor.authorCARVALHO, Carlos Roberto Ribeiro
dc.date.accessioned2014-01-28T22:19:33Z
dc.date.available2014-01-28T22:19:33Z
dc.date.issued2013
dc.description.abstractIntroduction: Positive responses to bronchodilators (BDs) on spirometry can be found in up to 30% of patients with lymphangioleiomyomatosis (LAM). However, no previous studies have investigated the impact of BDs on exercise outcomes, including dynamic hyperinflation (DH). Methods: A randomised, double-blind, placebo-controlled, crossover trial was conducted on 38 patients with LAM, comparing inhaled placebo versus salbutamol. Pulmonary function tests and a cycle endurance test at 75% of the maximal work capacity, with evaluation of DH by serial measurement of inspiratory capacity (IC), which was the primary endpoint, were performed after each intervention. Results: Although salbutamol produced a slight improvement in airway obstruction, compared with placebo, there was no significant variation in resting IC or air trapping. A total of 18% of the patients met the criteria for a positive response to BD. During submaximal exercise, BD did not reduce DH or dyspnoea nor did it improve exercise tolerance in the entire population. In addition, BD produced only slight improvement in FEV1 and air trapping in patients who had DH during incremental cardiopulmonary exercise testing, without the beneficial effects on exercise outcomes. Conclusions: Although salbutamol produced a slight improvement in airway obstruction, it did not lead to a reduction in DH or increase in exercise tolerance in patients with LAM. Clinical trial registration: Brazilian Registry of Clinical Trials (ReBEC); www.ensaiosclinicos.gov.br; registration number: RBR-49sk2j.
dc.description.indexMEDLINE
dc.identifier.citationRESPIRATORY MEDICINE, v.107, n.11, p.1773-1780, 2013
dc.identifier.doi10.1016/j.rmed.2013.08.045
dc.identifier.issn0954-6111
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4000
dc.language.isoeng
dc.publisherW B SAUNDERS CO LTD
dc.relation.ispartofRespiratory Medicine
dc.rightsrestrictedAccess
dc.rights.holderCopyright W B SAUNDERS CO LTD
dc.subjectAdrenergic beta-2 receptor agonists
dc.subjectExercise test
dc.subjectLymphangioleiomyomatosis
dc.subjectPulmonary function tests
dc.subject.otherair-flow obstruction
dc.subject.otherlung-function tests
dc.subject.otherpulmonary lymphangioleiomyomatosis
dc.subject.otherexercise performance
dc.subject.otherreference values
dc.subject.otherstandardization
dc.subject.otherdisease
dc.subject.othermechanics
dc.subject.otherefficacy
dc.subject.othercapacity
dc.subject.wosCardiac & Cardiovascular Systems
dc.subject.wosRespiratory System
dc.titleA pilot study assessing the effect of bronchodilator on dynamic hyperinflation in LAM
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcBRUNO GUEDES BALDI
hcfmusp.contributor.author-fmusphcANDRE LUIZ PEREIRA DE ALBUQUERQUE
hcfmusp.contributor.author-fmusphcSUZANA PINHEIRO PIMENTA
hcfmusp.contributor.author-fmusphcJOAO MARCOS SALGE
hcfmusp.contributor.author-fmusphcRONALDO ADIB KAIRALLA
hcfmusp.contributor.author-fmusphcCARLOS ROBERTO RIBEIRO DE CARVALHO
hcfmusp.description.beginpage1773
hcfmusp.description.endpage1780
hcfmusp.description.issue11
hcfmusp.description.volume107
hcfmusp.origemWOS
hcfmusp.origem.pubmed24064347
hcfmusp.origem.scopus2-s2.0-84887112532
hcfmusp.origem.wosWOS:000327230800016
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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