Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorASTLEY, Camilla
dc.contributor.authorLEAL, Gabriela Nunes
dc.contributor.authorGIL, Saulo
dc.contributor.authorSUGUITA, Priscila
dc.contributor.authorFINK, Thais
dc.contributor.authorBAIN, Vera
dc.contributor.authorPEREIRA, Maria Fernanda Badue
dc.contributor.authorMARQUES, Heloisa Helena
dc.contributor.authorSIECZKOWSKA, Sofia
dc.contributor.authorPRADO, Danilo
dc.contributor.authorLIMA, Marcos Santos
dc.contributor.authorCARNEIRO, Camila G.
dc.contributor.authorBUCHPIGUEL, Carlos Alberto
dc.contributor.authorSILVA, Clovis Artur
dc.contributor.authorGUALANO, Bruno
dc.date.accessioned2023-06-21T14:07:27Z
dc.date.available2023-06-21T14:07:27Z
dc.date.issued2023
dc.description.abstractObjective: To assess the potential therapeutic role of exercise on health-related quality of life, assessed by the Pediatric Outcomes Data Collection Instrument (PODCI), coronary flow reserve (CFR), cardiac function, cardiorespiratory fitness, and inflammatory and cardiac blood markers in multisystemic inflammatory syndrome in children (MIS-C) patients. Methods: This is a case series study of a 12-wk, home-based exercise intervention in children and adolescents after MIS-C diagnosis. From 16 MIS-C patients followed at our clinic, 6 were included (age: 7-16 years; 3 females). Three of them withdrew before the intervention and served as controls. The primary outcome was health-related quality of life, assessed PODCI. Secondary outcomes were CFR assessed by 13N-ammonia PET-CT imaging, cardiac function by echocardiography, cardiorespiratory fitness, and inflammatory and cardiac blood markers. Results: In general, patients showed poor health-related quality of life, which seemed to be improved with exercise. Additionally, exercised patients showed improvements in coronary flow reserve, cardiac function, and aerobic conditioning. Non-exercised patients exhibited a slower pattern of recovery, particularly in relation to health-related quality of life and aerobic conditioning. Conclusions: Our results suggest that exercise may play a therapeutic role in the treatment of post-discharge MIS-C patients. As our design does not allow inferring causality, randomized controlled trials are necessary to confirm these preliminary findings.eng
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [2021/02742-0, 2015/03756-4, 2019/15231-4, 2017/13552-2]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [2021/02742-0]
dc.description.sponsorship[303422/2015-7]
dc.identifier.citationCHILDREN-BASEL, v.10, n.5, article ID 889, 14p, 2023
dc.identifier.doi10.3390/children10050889
dc.identifier.eissn2227-9067
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/53881
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofChildren-Basel
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectCOVID-19eng
dc.subjectpediatric multisystem inflammatory diseaseeng
dc.subjectcardiovascular imagingeng
dc.subjectmicrovasculatureeng
dc.subjectexercise trainingeng
dc.subject.wosPediatricseng
dc.titleHome-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalGIL, Saulo:Univ Sao Paulo, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalSIECZKOWSKA, Sofia:Univ Sao Paulo, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalPRADO, Danilo:Univ Sao Paulo, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalCARNEIRO, Camila G.:Univ Sao Paulo, Clin Hosp, Sch Med, Dept Radiol & Oncol,Nucl Med Div, BR-05403911 Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcCAMILLA ASTLEY AMARAL PEDROSO
hcfmusp.contributor.author-fmusphcGABRIELA NUNES LEAL
hcfmusp.contributor.author-fmusphcPRISCILA DA SILVEIRA SUGUITA
hcfmusp.contributor.author-fmusphcTHAIS DE TOLEDO FINK
hcfmusp.contributor.author-fmusphcVERA BAIN
hcfmusp.contributor.author-fmusphcMARIA FERNANDA BADUE PEREIRA
hcfmusp.contributor.author-fmusphcHELOISA HELENA DE SOUSA MARQUES
hcfmusp.contributor.author-fmusphcMARCOS SANTOS LIMA
hcfmusp.contributor.author-fmusphcCARLOS ALBERTO BUCHPIGUEL
hcfmusp.contributor.author-fmusphcCLOVIS ARTUR ALMEIDA DA SILVA
hcfmusp.contributor.author-fmusphcBRUNO GUALANO
hcfmusp.description.articlenumber889
hcfmusp.description.issue5
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed37238437
hcfmusp.origem.scopus2-s2.0-85160334231
hcfmusp.origem.wosWOS:000997236000001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
hcfmusp.scopus.lastupdate2024-05-17
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