Association of Appendicular Lean Mass, and Subcutaneous and Visceral Adipose Tissue With Mortality in Older Brazilians: The Sao Paulo Ageing & Health Study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTANA, Felipe M. de
dc.contributor.authorDOMICIANO, Diogo S.
dc.contributor.authorGONCALVES, Michel A.
dc.contributor.authorMACHADO, Luana G.
dc.contributor.authorFIGUEIREDO, Camille P.
dc.contributor.authorLOPES, Jaqueline B.
dc.contributor.authorCAPARBO, Valeria F.
dc.contributor.authorTAKAYAMA, Lilliam
dc.contributor.authorMENEZES, Paulo R.
dc.contributor.authorPEREIRA, Rosa M. R.
dc.date.accessioned2019-08-20T14:46:24Z
dc.date.available2019-08-20T14:46:24Z
dc.date.issued2019
dc.description.abstractBody composition changes as a result of ageing may impact the survival of older adults. However, its influence on mortality risk is uncertain. Currently, the best method for body composition analysis in clinical practice is DXA. Nonetheless, the few studies on body composition by DXA and mortality risk in the elderly have some limitations. We investigated the association between body composition by DXA and mortality in a cohort of elderly subjects. Eight hundred thirty-nine community-dwelling subjects (516 women, 323 men) >= 65 years of age were assessed by a questionnaire, clinical data, laboratory exams, and body composition by DXA at baseline. Total fat and its components (eg, visceral adipose tissue [VAT]) were estimated. Appendicular lean mass (ALM) adjusted for fat and ALM divided by height(2) was used to ascertain the presence of low muscle mass (LMM). Mortality was recorded during follow-up. Multivariate logistic regression was used to compute ORs for all-cause and cardiovascular mortality. Over a mean follow-up of 4.06 +/- 1.07 years, there were 132 (15.7%) deaths. In men, after adjustment for relevant variables, the presence of LMM (OR, 11.36, 95% CI, 2.21 to 58.37, P = 0.004) and VAT (OR, 1.99, 95% CI, 1.38 to 2.87, P < 0.001, for each 100-g increase) significantly increased all-cause mortality risk, whereas total fat, measured by the fat mass index, was associated with decreased mortality risk (OR, 0.48, 95% CI, 0.33 to 0.71, P < 0.001). Similar results were observed for cardiovascular mortality. In women, only LMM was a predictor of all-cause (OR, 62.88, 95% CI, 22.59 to 175.0, P < 0.001) and cardiovascular death (OR, 74.54, 95% CI, 9.72 to 571.46, P < 0.001). LMM ascertained by ALM adjusted for fat and fat mass by itself are associated with all-cause and cardiovascular mortality risk in the elderly. Visceral and subcutaneous fat have opposite roles on mortality risk in elderly men. Thus, DXA is a promising tool to estimate risk of mortality in the elderly. (c) 2019 American Society for Bone and Mineral Research.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP) [03/09313-0, 04/12694-8, 09/15346-4, 11/00411-5]
dc.description.sponsorshipConselho Nacional de Ciencia e Tecnologia (CNPQ) [300559/2009-7, 301805/2013-0]
dc.description.sponsorshipFederico Foundation
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nvel Superior (CAPES)
dc.identifier.citationJOURNAL OF BONE AND MINERAL RESEARCH, v.34, n.7, p.1264-1274, 2019
dc.identifier.doi10.1002/jbmr.3710
dc.identifier.eissn1523-4681
dc.identifier.issn0884-0431
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33158
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Bone and Mineral Research
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectAGEINGeng
dc.subjectDXAeng
dc.subjectMORTALITYeng
dc.subjectSARCOPENIAeng
dc.subjectVISCERAL ADIPOSE TISSUEeng
dc.subject.otherx-ray absorptiometryeng
dc.subject.otherall-cause mortalityeng
dc.subject.otherskeletal-muscle masseng
dc.subject.otherbody-compositioneng
dc.subject.otheralternative definitionseng
dc.subject.otherrisk-factorseng
dc.subject.othersarcopeniaeng
dc.subject.otherfateng
dc.subject.othermeneng
dc.subject.otherpredictoreng
dc.subject.wosEndocrinology & Metabolismeng
dc.titleAssociation of Appendicular Lean Mass, and Subcutaneous and Visceral Adipose Tissue With Mortality in Older Brazilians: The Sao Paulo Ageing & Health Studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalLOPES, Jaqueline B.:Univ Sao Paulo, Fac Med, Div Rheumatol, Bone Metab Lab, Sao Paulo, Brazil
hcfmusp.citation.scopus33
hcfmusp.contributor.author-fmusphcFELIPE MENDONCA DE SANTANA
hcfmusp.contributor.author-fmusphcDIOGO SOUZA DOMICIANO
hcfmusp.contributor.author-fmusphcMICHEL AMORIM GONCALVES
hcfmusp.contributor.author-fmusphcLUANA GERHEIM MACHADO
hcfmusp.contributor.author-fmusphcCAMILLE PINTO FIGUEIREDO
hcfmusp.contributor.author-fmusphcVALERIA DE FALCO CAPARBO
hcfmusp.contributor.author-fmusphcLILIAM TAKAYAMA GUERRA
hcfmusp.contributor.author-fmusphcPAULO ROSSI MENEZES
hcfmusp.contributor.author-fmusphcROSA MARIA RODRIGUES PEREIRA
hcfmusp.description.beginpage1264
hcfmusp.description.endpage1274
hcfmusp.description.issue7
hcfmusp.description.volume34
hcfmusp.origemWOS
hcfmusp.origem.pubmed30866105
hcfmusp.origem.scopus2-s2.0-85069754352
hcfmusp.origem.wosWOS:000476766800015
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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