Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVESTRE, Marilene Chaves
dc.contributor.authorSATO, Maria Notomi
dc.contributor.authorREIS, Vitor Manoel Silva dos
dc.date.accessioned2018-07-05T18:02:30Z
dc.date.available2018-07-05T18:02:30Z
dc.date.issued2018
dc.description.abstractSkin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TNF, IL-1 beta, and IL-18, contributing to the development of Allergic Contact Dermatitis. Dendritic cells recognize and process antigenic peptides into T cells. Neutrophils cause pro-inflammatory reactions, mast cells induce migration/maturation of skin DCs, the natural killer cells have natural cytotoxic capacity, the gamma delta T cells favor contact with hapten during the sensitization phase, and the innate lymphoid cells act in the early stages by secreting cytokines, as well as act in inflammation and tissue homeostasis. The antigen-specific inflammation is mediated by T cells, and each subtype of T cells (Th1/Tc1, Th2/Tc2, and Th17/Tc17) activates resident skin cells, thus contributing to inflammation. Skin's regulatory T cells have a strong ability to inhibit the proliferation of hapten-specific T cells, acting at the end of the Allergic Contact Dermatitis response and in the control of systemic immune responses. In this review, we report how cutaneous innate immunity is the first line of defense and focus its role in the activation of the adaptive immune response, with effector response induction and its regulation.
dc.description.indexMEDLINE
dc.identifier.citationANAIS BRASILEIROS DE DERMATOLOGIA, v.93, n.2, p.242-250, 2018
dc.identifier.doi10.1590/abd1806-4841.20186340
dc.identifier.eissn1806-4841
dc.identifier.issn0365-0596
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/26933
dc.language.isoeng
dc.publisherSOC BRASILEIRA DERMATOLOGIA
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsopenAccess
dc.rights.holderCopyright SOC BRASILEIRA DERMATOLOGIA
dc.subjectAllergy and immunology
dc.subjectDermatitis
dc.subjectallergic contact
dc.subjectDermatitis
dc.subjectcontact
dc.subject.otherplasmacytoid dendritic cells
dc.subject.othercd8 t-cells
dc.subject.otherlangerhans cells
dc.subject.otherlymphoid-cells
dc.subject.otherviral-infection
dc.subject.otherhuman keratinocytes
dc.subject.otheradaptive immunity
dc.subject.othercutting edge
dc.subject.otheri interferon
dc.subject.otherhuman skin
dc.subject.wosDermatology
dc.titleInnate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSILVESTRE, Marilene Chaves:Univ Fed Goias, Dematol Serv, Dept Trop Med & Dematol, Goiania, Go, Brazil
hcfmusp.citation.scopus32
hcfmusp.contributor.author-fmusphcMARIA NOTOMI SATO
hcfmusp.contributor.author-fmusphcVITOR MANOEL SILVA DOS REIS
hcfmusp.description.beginpage242
hcfmusp.description.endpage250
hcfmusp.description.issue2
hcfmusp.description.volume93
hcfmusp.origemWOS
hcfmusp.origem.pubmed29723367
hcfmusp.origem.scieloSCIELO:S0365-05962018000200242
hcfmusp.origem.scopus2-s2.0-85046417746
hcfmusp.origem.wosWOS:000431299700013
hcfmusp.publisher.cityRIO DE JANEIRO RJ
hcfmusp.publisher.countryBRAZIL
hcfmusp.relation.referenceAlbanesi C, 2000, J INVEST DERMATOL, V115, P81, DOI 10.1046/j.1523-1747.2000.00041.x
hcfmusp.relation.referenceAlbanesi Cristina, 2005, Current Drug Targets - Inflammation and Allergy, V4, P329, DOI 10.2174/1568010054022033
hcfmusp.relation.referenceArtis D, 2015, NATURE, V517, P293, DOI 10.1038/nature14189
hcfmusp.relation.referenceBoyman O, 2007, TRENDS IMMUNOL, V28, P51, DOI 10.1016/j.it.2006.12.005
hcfmusp.relation.referenceBrodsky I, 2007, CELL, V130, P979, DOI 10.1016/j.cell.2007.09.009
hcfmusp.relation.referenceBursch LS, 2007, J EXP MED, V204, P3147, DOI 10.1084/jem.20071966
hcfmusp.relation.referenceCarbone T, 2010, J IMMUNOL, V184, P1102, DOI 10.4049/jimmunol.0902518
hcfmusp.relation.referenceCharbonnier AS, 1999, J EXP MED, V190, P1755, DOI 10.1084/jem.190.12.1755
hcfmusp.relation.referenceChow Z, 2013, J IMMUNOL, V191, P3049, DOI 10.4049/jimmunol.1203205
hcfmusp.relation.referenceConstantinides MG, 2014, NATURE, V508, P397, DOI 10.1038/nature13047
hcfmusp.relation.referenceCorsini E, 2000, TOXICOLOGY, V142, P203, DOI 10.1016/S0300-483X(99)00145-6
hcfmusp.relation.referenceDeaglio S, 2007, J EXP MED, V204, P1257, DOI 10.1084/jem.20062512
hcfmusp.relation.referenceDi Santo JP, 2008, EUR J IMMUNOL, V38, P2948, DOI 10.1002/eji.200838830
hcfmusp.relation.referenceDudeck A, 2011, IMMUNITY, V34, P973, DOI 10.1016/j.immuni.2011.03.028
hcfmusp.relation.referenceEgawa G, 2011, J INVEST DERMATOL, V131, P2178, DOI 10.1038/jid.2011.198
hcfmusp.relation.referenceEngeman T, 2004, J LEUKOCYTE BIOL, V76, P941, DOI 10.1189/jlb.0304193
hcfmusp.relation.referenceFukunaga A, 2008, J IMMUNOL, V180, P3057, DOI 10.4049/jimmunol.180.5.3057
hcfmusp.relation.referenceGilliet M, 2008, NAT REV IMMUNOL, V8, P594, DOI 10.1038/nri2358
hcfmusp.relation.referenceGinhoux F, 2007, J EXP MED, V204, P3133, DOI 10.1084/jem.20071733
hcfmusp.relation.referenceGondek DC, 2005, J IMMUNOL, V174, P1783, DOI 10.4049/jimmunol.174.4.1783
hcfmusp.relation.referenceGratz IK, 2013, ANN NY ACAD SCI, V1283, P8, DOI 10.1111/nyas.12011
hcfmusp.relation.referenceGratz IK, 2013, J IMMUNOL, V190, P4483, DOI 10.4049/jimmunol.1300212
hcfmusp.relation.referenceGri G, 2008, IMMUNITY, V29, P771, DOI 10.1016/j.immuni.2008.08.018
hcfmusp.relation.referenceHe DG, 2009, J IMMUNOL, V183, P1463, DOI 10.4049/jimmunol.0804108
hcfmusp.relation.referenceHomey B, 2002, NAT MED, V8, P157, DOI 10.1038/nm0202-157
hcfmusp.relation.referenceHonda T, 2013, J INVEST DERMATOL, V133, P303, DOI 10.1038/jid.2012.284
hcfmusp.relation.referenceHonda T, 2011, J DERMATOL SCI, V63, P75, DOI 10.1016/j.jdermsci.2011.06.004
hcfmusp.relation.referenceHonda T, 2010, J ALLERGY CLIN IMMUN, V125, P1154, DOI 10.1016/j.jaci.2009.12.005
hcfmusp.relation.referenceIshizaki K, 2007, J IMMUNOL, V178, P605, DOI 10.4049/jimmunol.178.1.605
hcfmusp.relation.referenceIto T, 2006, BLOOD, V107, P2423, DOI 10.1182/blood-2005-07-2709
hcfmusp.relation.referenceJego G, 2003, IMMUNITY, V19, P225, DOI 10.1016/S1074-7613(03)00208-5
hcfmusp.relation.referenceKabashima K, 2003, NAT MED, V9, P744, DOI 10.1038/nm872
hcfmusp.relation.referenceKaplan DH, 2012, NAT REV IMMUNOL, V12, P114, DOI 10.1038/nri3150
hcfmusp.relation.referenceKawai T, 2010, NAT IMMUNOL, V11, P373, DOI 10.1038/ni.1863
hcfmusp.relation.referenceKawamura T, 2014, J DERMATOL SCI, V75, P159, DOI 10.1016/j.jdermsci.2014.05.004
hcfmusp.relation.referenceKim BS, 2013, SCI TRANSL MED, V5, DOI 10.1126/scitranslmed.3005374
hcfmusp.relation.referenceKissenpfennig A, 2005, IMMUNITY, V22, P643, DOI 10.1016/j.immuni.2005.04.004
hcfmusp.relation.referenceKlose CSN, 2014, CELL, V157, P340, DOI 10.1016/j.cell.2014.03.030
hcfmusp.relation.referenceKolumam GA, 2005, J EXP MED, V202, P637, DOI 10.1084/jem.20050821
hcfmusp.relation.referenceLarsen JM, 2009, J ALLERGY CLIN IMMUN, V123, P486, DOI 10.1016/j.jaci.2008.09.036
hcfmusp.relation.referenceLebre MC, 2007, J INVEST DERMATOL, V127, P331, DOI 10.1038/sj.jid.5700530
hcfmusp.relation.referenceMantovani A, 2011, NAT REV IMMUNOL, V11, P519, DOI 10.1038/nri3024
hcfmusp.relation.referenceMarshall JS, 2003, CURR PHARM DESIGN, V9, P11, DOI 10.2174/1381612033392413
hcfmusp.relation.referenceMartin SF, 2011, ALLERGY, V66, P1152, DOI 10.1111/j.1398-9995.2011.02652.x
hcfmusp.relation.referenceMartin SF, 2008, J EXP MED, V205, P2151, DOI 10.1084/jem.20070509
hcfmusp.relation.referenceMartin SF, 2015, CONTACT DERMATITIS, V72, P2, DOI 10.1111/cod.12311
hcfmusp.relation.referenceMartinon F, 2009, ANNU REV IMMUNOL, V27, P229, DOI 10.1146/annurev.immunol.021908.132715
hcfmusp.relation.referenceMartins LEAM, 2011, AN BRAS DERMATOL, V86, P410
hcfmusp.relation.referenceMedzhitov R, 1997, CURR OPIN IMMUNOL, V9, P4, DOI 10.1016/S0952-7915(97)80152-5
hcfmusp.relation.referenceMitsui G, 2003, IMMUNOL LETT, V86, P191, DOI 10.1016/S0165-2478(03)00017-8
hcfmusp.relation.referenceMoretta A, 2008, CELL DEATH DIFFER, V15, P226, DOI 10.1038/sj.cdd.4402170
hcfmusp.relation.referenceMori T, 2008, J INVEST DERMATOL, V128, P1719, DOI 10.1038/jid.2008.5
hcfmusp.relation.referenceNeill DR, 2010, NATURE, V464, P1367, DOI 10.1038/nature08900
hcfmusp.relation.referenceNestle FO, 2009, NAT REV IMMUNOL, V9, P679, DOI 10.1038/nri2622
hcfmusp.relation.referenceNishibu A, 2007, J DERMATOL SCI, V45, P23, DOI 10.1016/j.jdermsci.2006.10.003
hcfmusp.relation.referencePaiva-Oliveira E. L., 2012, Revista de Ciencias Medicas e Biologicas, V11, P96
hcfmusp.relation.referencePaust S, 2011, NAT IMMUNOL, V12, P500, DOI 10.1038/ni.2032
hcfmusp.relation.referencePennino D, 2010, J IMMUNOL, V184, P4880, DOI 10.4049/jimmunol.0901767
hcfmusp.relation.referenceRandolph GJ, 2001, SEMIN IMMUNOL, V13, P267, DOI 10.1006/smim.2001.0322
hcfmusp.relation.referenceRicciardi L, 2009, CONTACT DERMATITIS, V60, P57, DOI 10.1111/j.1600-0536.2008.01454.x
hcfmusp.relation.referenceRing S, 2009, J ALLERGY CLIN IMMUN, V123, P1287, DOI 10.1016/j.jaci.2009.03.022
hcfmusp.relation.referenceRodriguez RS, 2014, J CLIN INVEST, V124, P1027, DOI 10.1172/JCI72932
hcfmusp.relation.referenceRomani N, 2010, IMMUNOL REV, V234, P120, DOI 10.1111/j.0105-2896.2009.00886.x
hcfmusp.relation.referenceSakaguchi S, 2006, IMMUNOL REV, V212, P8, DOI 10.1111/j.0105-2896.2006.00427.x
hcfmusp.relation.referenceSakaguchi S, 2010, NAT REV IMMUNOL, V10, P490, DOI 10.1038/nri2785
hcfmusp.relation.referenceSalimi M, 2014, BMC DERMATOL, V14, DOI 10.1186/1471-5945-14-18
hcfmusp.relation.referenceSampaio SAP, 2007, DERMATOLOGICA, P189
hcfmusp.relation.referenceSantini SM, 2000, J EXP MED, V191, P1777, DOI 10.1084/jem.191.10.1777
hcfmusp.relation.referenceSato N, 2007, CLIN EXP ALLERGY, V37, P743, DOI 10.1111/j.1365-2222.2007.02705.x
hcfmusp.relation.referenceSchmidt M, 2010, NAT IMMUNOL, V11, P814, DOI 10.1038/ni.1919
hcfmusp.relation.referenceSebastiani S, 2002, ARCH DERMATOL RES, V293, P552, DOI 10.1007/s00403-001-0276-9
hcfmusp.relation.referenceSimon D, 2014, ALLERGY, V69, P125, DOI 10.1111/all.12351
hcfmusp.relation.referenceSpits H, 2013, NAT REV IMMUNOL, V13, P145, DOI 10.1038/nri3365
hcfmusp.relation.referenceSurprenant A, 2009, ANNU REV PHYSIOL, V71, P333, DOI 10.1146/annurev.physiol.70.113006.100630
hcfmusp.relation.referenceTadokoro CE, 2006, J EXP MED, V203, P505, DOI 10.1084/jem.20050783
hcfmusp.relation.referenceTomura M, 2010, J CLIN INVEST, V120, P883, DOI 10.1172/JCI40926
hcfmusp.relation.referenceToulon A, 2009, J EXP MED, V206, P743, DOI 10.1084/jem.20081787
hcfmusp.relation.referenceTraidl C, 2000, J IMMUNOL, V165, P3058, DOI 10.4049/jimmunol.165.6.3058
hcfmusp.relation.referenceVocanson M, 2009, ALLERGY, V64, P1699, DOI 10.1111/j.1398-9995.2009.02082.x
hcfmusp.relation.referenceWakim LM, 2008, SCIENCE, V319, P198, DOI 10.1126/science.1151869
hcfmusp.relation.referenceWatanabe H, 2007, J INVEST DERMATOL, V127, P1956, DOI 10.1038/sj.jid.5700819
hcfmusp.relation.referenceWeaver CT, 2007, ANNU REV IMMUNOL, V25, P821, DOI 10.1146/annurev.immunol.25.022106.141557
hcfmusp.relation.referenceWeber FC, 2015, J EXP MED, V212, P15, DOI 10.1084/jem.20130062
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