Catechol-O-methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD After Urban Violence

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorVALENTE, Nina Leao Marques
dc.contributor.authorVALLADA, Homero
dc.contributor.authorCORDEIRO, Quirino
dc.contributor.authorBRESSAN, Rodrigo Affonseca
dc.contributor.authorANDREOLI, Sergio Baxter
dc.contributor.authorMARI, Jair Jesus
dc.contributor.authorMELLO, Marcelo Feijo
dc.date.accessioned2017-11-27T16:36:13Z
dc.date.available2017-11-27T16:36:13Z
dc.date.issued2011
dc.description.abstractPTSD is a psychiatric disorder that requires a traumatic event as diagnostic criteria. Brazil has high rates of violence, and it is expected that urban victims of violence would be at risk to the development of PTSD. Studies have associated the COMT val158met polymorphism with diminished stress resilience, reduced ability to extinguish conditioned fear, and the development of PTSD after multiple traumatic experiences. The aim of this study was to identify, in a case-control study, whether the val158met polymorphism (rs4860) is associated with the development of PTSD in a group of victims of urban violence. To our knowledge, this is the first study that examines the association between PTSD and urban violence. The polymorphism of COMT in PTSD patients (n = 65) as well as in victims of violence without PTSD (n = 34) and in a community control group (n = 335) were genotyped. We found a significant relationship between the met allele (p < 0.02) and PTSD among cases (PTSD+)and victims of violence without PTSD (PTSD-; OR 2.57) and between cases and community control group (p < 0.003) Further analysis with larger samples and another ethnic group should be necessary to confirm our findings.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [2004/15039-0]
dc.description.sponsorshipMinistry of Education (CAPES)
dc.identifier.citationJOURNAL OF MOLECULAR NEUROSCIENCE, v.43, n.3, p.516-523, 2011
dc.identifier.doi10.1007/s12031-010-9474-2
dc.identifier.issn0895-8696
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23573
dc.language.isoeng
dc.publisherHUMANA PRESS INC
dc.relation.ispartofJournal of Molecular Neuroscience
dc.rightsrestrictedAccess
dc.rights.holderCopyright HUMANA PRESS INC
dc.subjectPolymorphism
dc.subjectCOMT
dc.subjectPost traumatic stress disorder
dc.subjectPTSD
dc.subjectViolence
dc.subject.otherposttraumatic-stress-disorder
dc.subject.othergene-environment interaction
dc.subject.othernational comorbidity survey
dc.subject.otherpsychometric properties
dc.subject.otherholocaust survivors
dc.subject.othergenomic ancestry
dc.subject.othertraumatic events
dc.subject.otheryoung-adults
dc.subject.otherinventory
dc.subject.otherdepression
dc.subject.wosBiochemistry & Molecular Biology
dc.subject.wosNeurosciences
dc.titleCatechol-O-methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD After Urban Violence
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalVALENTE, Nina Leao Marques:Univ Fed Sao Paulo, Dept Psiquiatria, Fac Med, BR-04023061 Sao Paulo, SP, Brazil
hcfmusp.author.externalMARI, Jair Jesus:Kings Coll London, Inst Psychiat, Hlth Serv & Populat Res Dept, London WC2R 2LS, England
hcfmusp.citation.scopus46
hcfmusp.contributor.author-fmusphcHOMERO PINTO VALLADA FILHO
hcfmusp.contributor.author-fmusphcQUIRINO CORDEIRO JUNIOR
hcfmusp.description.beginpage516
hcfmusp.description.endpage523
hcfmusp.description.issue3
hcfmusp.description.volume43
hcfmusp.origemWOS
hcfmusp.origem.pubmed21080103
hcfmusp.origem.scopus2-s2.0-79955871350
hcfmusp.origem.wosWOS:000287503500036
hcfmusp.publisher.cityTOTOWA
hcfmusp.publisher.countryUSA
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