Toxicological insights of Spike fragments SARS-CoV-2 by exposure environment: A threat to aquatic health?

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art_CHARLIE-SILVA_Toxicological_insights_of_Spike_fragments_SARSCoV2_by_exposure_2021.PDF (7.35 MB)
Citações na Scopus
21
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER
Autores
CHARLIE-SILVA, Ives
ARAUJO, Amanda P. C.
GUIMARAES, Abraao T. B.
VERAS, Flavio P.
BRAZ, Helyson L. B.
PONTES, Leticia G. de
JORGE, Roberta J. B.
BELO, Marco A. A.
NOBREGA, Rafael H.
Citação
JOURNAL OF HAZARDOUS MATERIALS, v.419, article ID 126463, 11p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The Spike protein (S protein) is a critical component in the infection of the new coronavirus (SARS-CoV-2). The objective of this work was to evaluate whether peptides from S protein could cause negative impact in the aquatic animals. The aquatic toxicity of SARS-CoV-2 Spike protein peptides derivatives has been evaluated in tadpoles (n = 50 tadpoles/5 replicates of 10 animals) from species Physalaemus cuvieri (Leptodactylidae). After synthesis, purification, and characterization of peptides (PSDP2001, PSDP2002, PSDP2003) an aquatic contamination has been simulated with these peptides during 24 h of exposure in two concentrations (100 and 500 ng/mL). The control group (""C"") was composed of tadpoles kept in polyethylene containers containing dechlorinated water. Oxidative stress, antioxidant biomarkers and AChE activity were assessed. In both concentrations, PSPD2002 and PSPD2003 increased catalase and superoxide dismutase antioxidants enzymes activities, as well as oxidative stress (nitrite levels, hydrogen peroxide and reactive oxygen species). All three peptides also increased acetylcholinesterase activity in the highest concentration. These peptides showed molecular interactions in silico with acetylcholinesterase and antioxidant enzymes. Aquatic particle contamination of SARS-CoV-2 has cholinesterasic effect in P. cuvieri tadpoles. These findings indicate that the COVID-19 can constitute environmental impact or biological damage potential.
Palavras-chave
Oxidative stress, Coronavirus, Amphibians, Acetylcholinesterase, SARS-Cov-2
URI
https://observatorio.fm.usp.br/handle/OPI/48674
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - LIM/42
Artigos e Materiais de Revistas Científicas - ODS/03