Hypertension Severity Is Associated With Impaired Cognitive Performance

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMUELA, Henrique C. S.
dc.contributor.authorCOSTA-HONG, Valeria A.
dc.contributor.authorYASSUDA, Monica S.
dc.contributor.authorMORAES, Natalia C.
dc.contributor.authorMEMORIA, Claudia M.
dc.contributor.authorMACHADO, Michel F.
dc.contributor.authorMACEDO, Thiago A.
dc.contributor.authorSHU, Edson B. S.
dc.contributor.authorMASSARO, Ayrton R.
dc.contributor.authorNITRINI, Ricardo
dc.contributor.authorMANSUR, Alfredo J.
dc.contributor.authorBORTOLOTTO, Luiz A.
dc.date.accessioned2017-04-07T15:08:57Z
dc.date.available2017-04-07T15:08:57Z
dc.date.issued2017
dc.description.abstractBackground-Most evidence of target-organ damage in hypertension (HTN) is related to the kidneys and heart. Cerebrovascular and cognitive impairment are less well studied. Therefore, this study analyzed changes in cognitive function in patients with different stages of hypertension compared to nonhypertensive controls. Methods and Results-In a cross-sectional study, 221 (71 normotensive and 150 hypertensive) patients were compared. Patients with hypertension were divided into 2 stages according to blood pressure (BP) levels or medication use (HTN-1: BP, 140-159/90-99 or use of 1 or 2 antihypertensive drugs; HTN-2: BP, >= 160/100 or use of >= 3 drugs). Three groups were comparatively analyzed: normotension, HTN stage 1, and HTN stage 2. The Mini-Mental State Examination, Montreal Cognitive Assessment, and a validated comprehensive battery of neuropsychological tests that assessed 6 main cognitive domains were used to determine cognitive function. Compared to the normotension and HTN stage-1, the severe HTN group had worse cognitive performance based on MiniMental State Examination (26.8 +/- 2.1 vs 27.4 +/- 2.1 vs 28.0 +/- 2.0; P= 0.004) or Montreal Cognitive Assessment (23.4 +/- 3.7 vs 24.9 +/- 2.8 vs 25.5 +/- 3.2; P< 0.001). On the neuropsychological tests, patients with hypertension had worse performance in language, processing speed, visuospatial abilities, and memory. Age, hypertension stage, and educational level were the best predictors of cognitive impairment in patients with hypertension in different cognitive domains. Conclusions-Cognitive impairment was more frequent in patients with hypertension, and this was related to hypertension severity.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF THE AMERICAN HEART ASSOCIATION, v.6, n.1, article ID e004579, 10p, 2017
dc.identifier.doi10.1161/JAHA.116.004579
dc.identifier.issn2047-9980
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/18854
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofJournal of the American Heart Association
dc.rightsopenAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectcognition
dc.subjectcognitive impairment
dc.subjecthigh blood pressure
dc.subjecthypertension
dc.subject.othermini-mental-state
dc.subject.otherischemic vascular dementia
dc.subject.otherblood-pressure levels
dc.subject.otheralzheimers-disease
dc.subject.otherverbal fluency
dc.subject.otherprevalence
dc.subject.othereducation
dc.subject.otherpopulation
dc.subject.otherintelligence
dc.subject.othervalidation
dc.subject.wosCardiac & Cardiovascular Systems
dc.titleHypertension Severity Is Associated With Impaired Cognitive Performance
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalMACHADO, Michel F.:Univ Sao Paulo, Sch Med, Dept Neurol, Sao Paulo, Brazil
hcfmusp.citation.scopus67
hcfmusp.contributor.author-fmusphcHENRIQUE COTCHI SIMBO MUELA
hcfmusp.contributor.author-fmusphcVALERIA APARECIDA DA COSTA HONG
hcfmusp.contributor.author-fmusphcMONICA SANCHES YASSUDA
hcfmusp.contributor.author-fmusphcNATALIA CRISTINA MORAES
hcfmusp.contributor.author-fmusphcCLAUDIA MAIA MEMORIA
hcfmusp.contributor.author-fmusphcTHIAGO ANDRADE DE MACEDO
hcfmusp.contributor.author-fmusphcEDSON BOR-SENG SHU
hcfmusp.contributor.author-fmusphcAYRTON ROBERTO MASSARO
hcfmusp.contributor.author-fmusphcRICARDO NITRINI
hcfmusp.contributor.author-fmusphcALFREDO JOSE MANSUR
hcfmusp.contributor.author-fmusphcLUIZ APARECIDO BORTOLOTTO
hcfmusp.description.articlenumbere004579
hcfmusp.description.issue1
hcfmusp.description.volume6
hcfmusp.origemWOS
hcfmusp.origem.pubmed28077386
hcfmusp.origem.scopus2-s2.0-85009961963
hcfmusp.origem.wosWOS:000393593300019
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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