Olfactory Function in SCA10

Imagem de Miniatura
Arquivos
art_MOSCOVICH_Olfactory_Function_in_SCA10_2019.PDF (641.86 KB)
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
MOSCOVICH, Mariana
MUNHOZ, Renato Puppi
MORO, Adriana
RASKIN, Salmo
MCFARLAND, Karen
ASHIZAWA, Tetsuo
TEIVE, Helio A. G.
Citação
CEREBELLUM, v.18, n.1, Special Issue, p.85-90, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Although the main clinical manifestations of spinocerebellar ataxias (SCAs) result from damage of the cerebellum, other systems may also be involved. Olfactory deficits have been reported in other types of ataxias, especially in SCA3; however, there are no studies on olfactory deficits in SCA type 10 (SCA10). To analyze olfactory function of SCA10 patients compared with that of SCA3, Parkinson's, and healthy controls. Olfactory identification was tested in three groups of 30 patients (SCA10, SCA3, and Parkinson's disease (PD)) and 44 healthy controls using the Sniffin' Sticks (SS16) test. Mean SS16 score was 11.9 +/- 2.9 for the SCA10 group, 12.3 +/- 1.9 for the SCA3 group, 6.6 +/- 2.8 for the PD group, and 12.1 +/- 2.0 for the control group. Mean SS16 score for the SCA10 group was not significantly different from the scores for the SCA3 and control groups but was significantly higher than the score for the PD group (p<0.001) when adjusted for age, gender, and history of smoking. There was no association between SS16 scores and disease duration in the SCA10 or SCA3 groups or number of repeat expansions. SS16 and Mini Mental State Examination scores were correlated in the three groups: SCA10 group (r=0.59, p=0.001), SCA3 group (r=0.50, p=0.005), and control group (r=0.40, p=0.007). We found no significant olfactory deficits in SCA10 in this large series.
Palavras-chave
Cerebellar degeneration, Movement disorders, Olfaction, Spinocerebellar ataxia, Smell
URI
https://observatorio.fm.usp.br/handle/OPI/31238
Referências
  1. Abele M, 2003, J NEUROL, V250, P1453, DOI 10.1007/s00415-003-0248-4
  2. Ahlskog JE, 1998, NEUROLOGY, V51, P1672, DOI 10.1212/WNL.51.6.1672
  3. Braga-Neto P, 2011, PARKINSONISM RELAT D, V17, P353, DOI 10.1016/j.parkreldis.2011.02.004
  4. Brucki SMD, 2003, ARQ NEURO-PSIQUIAT, V61, P777, DOI 10.1590/S0004-282X2003000500014
  5. Connelly T, 2003, J NEUROL NEUROSUR PS, V74, P1435, DOI 10.1136/jnnp.74.10.1435
  6. Fernandez-Ruiz J, 2003, NEUROREPORT, V14, P1339, DOI 10.1097/01.wnr.0000077551.91466.d3
  7. Galvez V, 2014, PARKINSONISM RELAT D, V20, P499, DOI 10.1016/j.parkreldis.2014.01.024
  8. Hawkes C, 2003, MOVEMENT DISORD, V18, P364, DOI 10.1002/mds.10379
  9. Houlden H, 2012, J NEUROL NEUROSUR PS, V83, P952, DOI 10.1136/jnnp-2012-303136
  10. HUGHES AJ, 1992, J NEUROL NEUROSUR PS, V55, P181, DOI 10.1136/jnnp.55.3.181
  11. HUMMEL T, 1992, ELECTROEN CLIN NEURO, V84, P84, DOI 10.1016/0168-5597(92)90070-R
  12. Kobal G., 1996, Rhinology (Utrecht), V34, P222
  13. Kovacs T, 2004, AGEING RES REV, V3, P215, DOI 10.1016/j.arr.2003.10.003
  14. Matsuura T, 2002, ADV EXP MED BIOL, V516, P79
  15. Matsuura T, 2002, ANN NEUROL, V51, P271, DOI 10.1002/ana.10049
  16. Mesholam RI, 1998, ARCH NEUROL-CHICAGO, V55, P84, DOI 10.1001/archneur.55.1.84
  17. Morley JF, 2011, MOVEMENT DISORD, V26, P2051, DOI 10.1002/mds.23792
  18. Moro A, 2017, CEREBELLUM, V16, P938, DOI 10.1007/s12311-017-0869-2
  19. Moro A, 2014, ARQ NEURO-PSIQUIAT, V72, P659, DOI 10.1590/0004-282X20140129
  20. Moscovich M, 2012, J NEUROL NEUROSUR PS, V83, P970, DOI 10.1136/jnnp-2012-302770
  21. Paulson Henry, 2012, Handb Clin Neurol, V103, P437, DOI 10.1016/B978-0-444-51892-7.00027-9
  22. Qureshy A, 2000, J NEUROPHYSIOL, V84, P1656
  23. Savic I, 2002, HUM BRAIN MAPP, V17, P17, DOI 10.1002/hbm.10045
  24. Savic I, 2002, NEUROSCIENTIST, V8, P204, DOI 10.1177/1073858402008003006
  25. Schmitz-Hubsch T, 2006, NEUROLOGY, V66, P1717, DOI 10.1212/01.wnl.0000219042.60538.92
  26. Silveira-Moriyama L, 2008, NEUROLOGY, V71, P1021, DOI 10.1212/01.wnl.0000326575.20829.45
  27. Silveira-Moriyama L, 2010, ARQ NEURO-PSIQUIAT, V68, P700, DOI 10.1590/S0004-282X2010000500005
  28. Silveira-Moriyama L, 2010, MOVEMENT DISORD, V25, P570, DOI 10.1002/mds.22688
  29. Subramony SH, 2007, NAT CLIN PRACT NEURO, V3, P136, DOI 10.1038/ncpneuro0426
  30. Teive HAG, 2004, NEUROLOGY, V63, P1509
  31. Teive HAG, 2008, ARQ NEURO-PSIQUIAT, V66, P691, DOI 10.1590/S0004-282X2008000500015
  32. Teive HAG, 2015, CURR OPIN NEUROL, V28, P413, DOI 10.1097/WCO.0000000000000227
  33. Teive HAG, 2011, PARKINSONISM RELAT D, V17, P655, DOI 10.1016/j.parkreldis.2011.04.001
  34. Teive HAG, 2010, MOVEMENT DISORD, V25, P2875, DOI 10.1002/mds.23324
  35. Velazquez-Perez L, 2006, J NEUROL, V253, P1165, DOI 10.1007/s00415-006-0183-2
  36. Yousem DM, 1997, RADIOLOGY, V204, P833, DOI 10.1148/radiology.204.3.9280268

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC