LAURA SILVEIRA MORIYAMA
Índice h a partir de 2011
3
Projetos de Pesquisa
Unidades Organizacionais
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- Neuroplasticity and neuromodulation in children(2017) SILVEIRA-MORIYAMA, Laura
- The Hitchhiker's guide to the rhinencephalon(2016) SILVEIRA-MORIYAMA, Laura; GLASS, Philip; RAJAN, Suraj; CARVALHO, Rafael; REIS, Fabiano; PENATTI, Carlos A. A.; MUIO, ValeriaPathology of the rhinencephalon has been a subject of interest in the fields of neurodegenerative diseases, trauma, epilepsy and other neurological conditions. Most of what is known about the human rhinencephalon comes from comparative anatomy studies in other mammals and histological studies in primates. Functional imaging studies can provide new and important insight into the function of the rhinencephalon in humans but have limited spatial resolution, limiting its contribution to the study of the anatomy of the human rhinencephalon. In this study we aim to provide a brief and objective review of the anatomy of this important and often overlooked area of the nervous system.
- Dramatic improvement of tardive dyskinesia movements by inline skating(2017) CASAGRANDE, Sara Carvalho Barbosa; CURY, Rubens Gisbert; LIMA-PARDINI, Andrea Cristina de; COELHO, Daniel Boari; SOUZA, Carolina de Oliveira; GHILARDI, Maria Gabriela dos Santos; SILVEIRA-MORIYAMA, Laura; TEIXEIRA, Luis Augusto; BARBOSA, Egberto Reis; FONOFF, Erich Talamoni
- Olfactory Function in SCA10(2019) MOSCOVICH, Mariana; MUNHOZ, Renato Puppi; MORO, Adriana; RASKIN, Salmo; MCFARLAND, Karen; ASHIZAWA, Tetsuo; TEIVE, Helio A. G.; SILVEIRA-MORIYAMA, LauraAlthough the main clinical manifestations of spinocerebellar ataxias (SCAs) result from damage of the cerebellum, other systems may also be involved. Olfactory deficits have been reported in other types of ataxias, especially in SCA3; however, there are no studies on olfactory deficits in SCA type 10 (SCA10). To analyze olfactory function of SCA10 patients compared with that of SCA3, Parkinson's, and healthy controls. Olfactory identification was tested in three groups of 30 patients (SCA10, SCA3, and Parkinson's disease (PD)) and 44 healthy controls using the Sniffin' Sticks (SS16) test. Mean SS16 score was 11.9 +/- 2.9 for the SCA10 group, 12.3 +/- 1.9 for the SCA3 group, 6.6 +/- 2.8 for the PD group, and 12.1 +/- 2.0 for the control group. Mean SS16 score for the SCA10 group was not significantly different from the scores for the SCA3 and control groups but was significantly higher than the score for the PD group (p<0.001) when adjusted for age, gender, and history of smoking. There was no association between SS16 scores and disease duration in the SCA10 or SCA3 groups or number of repeat expansions. SS16 and Mini Mental State Examination scores were correlated in the three groups: SCA10 group (r=0.59, p=0.001), SCA3 group (r=0.50, p=0.005), and control group (r=0.40, p=0.007). We found no significant olfactory deficits in SCA10 in this large series.
- Relationship of socioeconomic status to olfactory function(2019) FORNAZIERI, Marco Aurelio; DOTY, Richard L.; BEZERRA, Thiago Freire Pinto; PINNA, Fabio de Rezende; COSTA, Fernando Oliveira; VOEGELS, Richard Louis; SILVEIRA-MORIYAMA, LauraSocioeconomic status can significantly impact health. To what degree education and other socioeconomic factors influence the chemical sense of olfaction is not clear. Most studies that have assessed such influences come from countries lacking large disparities in education and income and generally view such measures as nuisance variables to be controlled for statistically. In this study, we evaluated the influences of education and income on odor identification in a diverse sample of subjects from Brazil, a society where large disparities in both income and education are present. The 40-item University of Pennsylvania Smell Identification Test (UPSIT) was administered to 1572 healthy Brazilian citizens with no self-reported olfactory or gustatory deficits and for whom detailed socioeconomic and educational status data were obtained. Univariate and multivariate models were employed to examine the influence of socioeconomic status on the test scores. After controlling for age, sex, ethnicity, and smoking behavior, income and educational level were positively and independently related to the olfactory test scores (respective ps < 0.001 & 0.01). Both linear and quadratic functions described the relationship between the UPSIT scores and the levels of education and socioeconomic status. Individuals of lower socioeconomic status performed significantly worse than those of higher socioeconomic status on 20 of the 40 odorant items. This study demonstrates socioeconomic status is significantly associated with influence the ability to identify odors. The degree to which this reflects differential exposures to xenobiotic agents, cultural differences, familiarity with odors or their names, cognitive development, or other factors requires further investigation.