Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon

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Arquivos
art_RIBEIRO_Adaptive_Evolution_of_New_Variants_of_Dengue_Virus_2021.PDF (1.73 MB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
RIBEIRO, Geovani de Oliveira
RIBEIRO, Edcelha Soares D. Athaide
MONTEIRO, Fred Julio Costa
REGO, Marlisson Octavio da S.
ARAUJO, Emerson Luiz Lima
WITKIN, Steven S.
VILLANOVA, Fabiola
Citação
VIRUSES-BASEL, v.13, n.4, article ID 689, 10p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Dengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this study, plasma samples (n = 824) from individuals with symptoms consistent with an arboviral febrile illness were analyzed to identity the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapa. Twelve DENV type 1 (DENV-1) genomes were identified, which were phylogenetically related to the BR4 lineage of genotype V. Phylodynamics analysis suggested that DENV-1 BR-4 was introduced into Amapa around early 2010, possibly from other states in northern Brazil. We also found unique amino acids substitutions in the DENV-1 envelope and NS5 protein sequences in the Amapa isolates. Characterization of the DENV-1 BR-4 sequences highlights the potential of this new lineage to drive outbreaks of dengue in the Amazon region.
Palavras-chave
arbovirus, flavivirus, Dengue, phylogeography, evolution, Brazil, Amazon, genomic surveillance
URI
https://observatorio.fm.usp.br/handle/OPI/40705
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/46
Artigos e Materiais de Revistas Científicas - ODS/03