Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMANFRO, Arthur Gus
dc.contributor.authorPINE, Daniel S.
dc.contributor.authorPOLANCZYK, Guilherme Vanoni
dc.contributor.authorSANTORO, Marcos
dc.contributor.authorSMOLLER, Jordan Wassertheil
dc.contributor.authorKOENEN, Karestan
dc.contributor.authorMARI, Jair
dc.contributor.authorPAN, Pedro Mario
dc.contributor.authorZUGMAN, Andre
dc.contributor.authorSCHAFER, Julia Luiza
dc.contributor.authorBELANGERO, Sintia
dc.contributor.authorGOSMANN, Natan Pereira
dc.contributor.authorSIMIONI, Andre Rafael
dc.contributor.authorHOEXTER, Marcelo Queiroz
dc.contributor.authorMIGUEL, Euripedes Constantino
dc.contributor.authorGADELHA, Ary
dc.contributor.authorROHDE, Luis Augusto
dc.contributor.authorSALUM, Giovanni Abrahao
dc.date.accessioned2022-02-24T17:18:51Z
dc.date.available2022-02-24T17:18:51Z
dc.date.issued2021
dc.description.abstractObjective: It is unclear if pediatric executive dysfunction assessed only with cognitive tasks predicts clinically relevant outcomes independently of psychiatric diagnoses. This study tested the stability and validity of a task-based classification of executive function. Method: A total of 2,207 individuals (6-17 years old) from the Brazilian High-Risk Cohort Study participated in this study (1,930 at baseline, 1,532 at follow-up). Executive function was measured using tests of working memory and inhibitory control. Dichotomized age-and sex-standardized performances were used as input in latent class analysis and receiver operating curves to create an executive dysfunction classification (EDC). The study tested EDC's stability over time, association with symptoms, functional impairment, a polymorphism in the CADM2 gene, polygenic risk scores (PRS), and brain structure. Analyses covaried for age, sex, social class, IQ, and psychiatric diagnoses. Results: EDC at baseline predicted itself at follow-up (odds ratio [OR] = 5.11; 95% CI 3.41-7.64). Participants in the EDC reported symptoms spanning several domains of psychopathology and exhibited impairment in multiple settings, including more adverse school events (OR = 2.530; 95% CI 1.838-3.483). Children in the EDC presented higher attention-deficit/hyperactivity disorder and lower educational attainment PRS at baseline; higher schizophrenia PRS at follow-up; and lower chances of presenting a polymorphism in a gene previously linked to high performance in executive function (CADM2 gene). They also exhibited smaller intracranial volumes and smaller bilateral cortical surface areas in several brain regions. Conclusion: Task-based executive dysfunction is associated with several validators, independently of psychiatric diagnoses and intelligence. Further refinement of task-based assessments might generate clinically useful tools.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil (CNPq, Brazil)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)Fundacao de Apoio a Pesquisa do Distrito Federal (FAPDF) [573974/2008-0]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil (CAPES)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil (FAPESP, Brazil)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2008/57896-8]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul, BrazilFundacao de Amparo a Ciencia e Tecnologia do Estado do Rio Grande do Sul (FAPERGS)
dc.description.sponsorshipNational Institute of Mental Health Intramural Research ProgramUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [MH-002781]
dc.identifier.citationJOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, v.60, n.12, p.1501-1512, 2021
dc.identifier.doi10.1016/j.jaac.2020.11.016
dc.identifier.eissn1527-5418
dc.identifier.issn0890-8567
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44554
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofJournal of the American Academy of Child and Adolescent Psychiatry
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subjectexecutive functioneng
dc.subjectgeneticseng
dc.subjectneuroimageeng
dc.subjectneuropsychologyeng
dc.subjectresearch domain criteriaeng
dc.subject.otherattention-deficit/hyperactivity disordereng
dc.subject.otherpsychiatric-disorderseng
dc.subject.otherworking-memoryeng
dc.subject.otherfunction deficitseng
dc.subject.otheridentificationeng
dc.subject.otherheterogeneityeng
dc.subject.otherneuropsychologyeng
dc.subject.otherinterventionseng
dc.subject.othersubtypeseng
dc.subject.otherimpacteng
dc.subject.wosPsychology, Developmentaleng
dc.subject.wosPediatricseng
dc.subject.wosPsychiatryeng
dc.titleTesting the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescentseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalMANFRO, Arthur Gus:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Sect Negat Affects & Social Proc, Porto Alegre, RS, Brazil
hcfmusp.author.externalPINE, Daniel S.:US Natl Inst Mental Hlth, Natl Inst Mental Hlth Intramural Res Program, Bethesda, MD USA
hcfmusp.author.externalSANTORO, Marcos:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Univ Fedorade Sao Pau, Sao Paulo, Brazil
hcfmusp.author.externalSMOLLER, Jordan Wassertheil:Massachusetts Gen Hosp, Boston, MA 02114 USA
hcfmusp.author.externalKOENEN, Karestan:Harvard TH Chan Sch Publ Hlth, Boston, MA USA
hcfmusp.author.externalMARI, Jair:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Univ Fedorade Sao Pau, Sao Paulo, Brazil
hcfmusp.author.externalPAN, Pedro Mario:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Univ Fedorade Sao Pau, Sao Paulo, Brazil
hcfmusp.author.externalSCHAFER, Julia Luiza:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Sect Negat Affects & Social Proc, Porto Alegre, RS, Brazil
hcfmusp.author.externalBELANGERO, Sintia:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Univ Fedorade Sao Pau, Sao Paulo, Brazil
hcfmusp.author.externalGOSMANN, Natan Pereira:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Sect Negat Affects & Social Proc, Porto Alegre, RS, Brazil
hcfmusp.author.externalSIMIONI, Andre Rafael:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Sect Negat Affects & Social Proc, Porto Alegre, RS, Brazil
hcfmusp.author.externalGADELHA, Ary:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Univ Fedorade Sao Pau, Sao Paulo, Brazil
hcfmusp.author.externalROHDE, Luis Augusto:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Sect Negat Affects & Social Proc, Porto Alegre, RS, Brazil
hcfmusp.author.externalSALUM, Giovanni Abrahao:Natl Inst Dev Psychiat INPD, CNPq, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Sect Negat Affects & Social Proc, Porto Alegre, RS, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcGUILHERME VANONI POLANCZYK
hcfmusp.contributor.author-fmusphcANDRE ZUGMAN
hcfmusp.contributor.author-fmusphcMARCELO QUEIROZ HOEXTER
hcfmusp.contributor.author-fmusphcEURIPEDES CONSTANTINO MIGUEL FILHO
hcfmusp.description.beginpage1501
hcfmusp.description.endpage1512
hcfmusp.description.issue12
hcfmusp.description.volume60
hcfmusp.origemWOS
hcfmusp.origem.pubmed33346031
hcfmusp.origem.scopus2-s2.0-85103405042
hcfmusp.origem.wosWOS:000720999300013
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAchenbach T M, 2000, Pediatr Rev, V21, P265, DOI 10.1542/pir.21-8-265eng
hcfmusp.relation.referenceAmerican Psychiatric Association, 2013, DIAGNOSTIC STAT MANU, V5th, DOI 10.1176/appi.books.9780890425596eng
hcfmusp.relation.referenceAnderson P, 2002, CHILD NEUROPSYCHOL, V8, P71, DOI 10.1076/chin.8.2.71.8724eng
hcfmusp.relation.referenceArnedo J, 2015, AM J PSYCHIAT, V172, P139, DOI 10.1176/appi.ajp.2014.14040435eng
hcfmusp.relation.referenceAssociacao Brasileira de Empresas de Pesquisa (ABEP), BRAZ EC CLASS CRITeng
hcfmusp.relation.referenceBathelt J, 2018, J AM ACAD CHILD PSY, V57, P252, DOI 10.1016/j.jaac.2018.01.014eng
hcfmusp.relation.referenceBENJAMINI Y, 1995, J R STAT SOC B, V57, P289, DOI 10.1111/j.2517-6161.1995.tb02031.xeng
hcfmusp.relation.referenceBiederman J, 2004, J CONSULT CLIN PSYCH, V72, P757, DOI 10.1037/0022-006X.72.5.757eng
hcfmusp.relation.referenceBigdeli TB, 2020, MOL PSYCHIATR, V25, P2455, DOI 10.1038/s41380-019-0517-yeng
hcfmusp.relation.referenceBitsakou P, 2008, J NEURAL TRANSM, V115, P261, DOI 10.1007/s00702-007-0828-zeng
hcfmusp.relation.referenceBlakey E, 2015, FRONT PSYCHOL, V6, DOI 10.3389/fpsyg.2015.01827eng
hcfmusp.relation.referenceBordin I. A. S., 1995, Revista ABP-APAL (Associacao Brasileira de Psiquiatria-Asociacion Psiquiatrica de la America Latina), V17, P55eng
hcfmusp.relation.referenceBree KD, 2016, APPL NEUROPSYCH-CHIL, V5, P202, DOI 10.1080/21622965.2016.1167504eng
hcfmusp.relation.referenceChan RCK, 2008, ARCH CLIN NEUROPSYCH, V23, P201, DOI 10.1016/j.acn.2007.08.010eng
hcfmusp.relation.referenceClementz BA, 2016, AM J PSYCHIAT, V173, P373, DOI 10.1176/appi.ajp.2015.14091200eng
hcfmusp.relation.referenceCoghill D, 2014, J CHILD PSYCHOL PSYC, V55, P737, DOI 10.1111/jcpp.12284eng
hcfmusp.relation.referenceDemontis D, 2019, NAT GENET, V51, P63, DOI 10.1038/s41588-018-0269-7eng
hcfmusp.relation.referenceDiamond A, 2011, SCIENCE, V333, P959, DOI 10.1126/science.1204529eng
hcfmusp.relation.referenceDowsett SM, 2000, DEV PSYCHOBIOL, V36, P161, DOI 10.1002/(SICI)1098-2302(200003)36:2<161::AID-DEV7>3.0.CO;2-0eng
hcfmusp.relation.referenceDrysdale AT, 2017, NAT MED, V23, P28, DOI 10.1038/nm.4246eng
hcfmusp.relation.referenceEuesden J, 2015, BIOINFORMATICS, V31, P1466, DOI 10.1093/bioinformatics/btu848eng
hcfmusp.relation.referenceFair DA, 2012, P NATL ACAD SCI USA, V109, P6769, DOI 10.1073/pnas.1115365109eng
hcfmusp.relation.referenceFeczko E, 2019, TRENDS COGN SCI, V23, P584, DOI 10.1016/j.tics.2019.03.009eng
hcfmusp.relation.referenceFischl B, 2012, NEUROIMAGE, V62, P774, DOI 10.1016/j.neuroimage.2012.01.021eng
hcfmusp.relation.referenceForbes NF, 2009, PSYCHOL MED, V39, P889, DOI 10.1017/S0033291708004558eng
hcfmusp.relation.referenceGiacomoni Claudia Hofheinz, 2015, Psico-USF, V20, P133, DOI 10.1590/1413-82712015200112eng
hcfmusp.relation.referenceGoodman R, 2000, J CHILD PSYCHOL PSYC, V41, P645, DOI 10.1111/j.1469-7610.2000.tb02345.xeng
hcfmusp.relation.referenceGoodman R, 2000, BRIT J PSYCHIAT, V177, P534, DOI 10.1192/bjp.177.6.534eng
hcfmusp.relation.referenceHofmann W, 2012, TRENDS COGN SCI, V16, P174, DOI 10.1016/j.tics.2012.01.006eng
hcfmusp.relation.referenceHogan AM, 2005, DEVELOPMENTAL SCI, V8, P525, DOI 10.1111/j.1467-7687.2005.00444.xeng
hcfmusp.relation.referenceIbrahim-Verbaas CA, 2016, MOL PSYCHIATR, V21, P189, DOI 10.1038/mp.2015.37eng
hcfmusp.relation.referenceIng A, 2019, NAT HUM BEHAV, V3, P1306, DOI 10.1038/s41562-019-0738-8eng
hcfmusp.relation.referenceInsel T, 2010, AM J PSYCHIAT, V167, P748, DOI 10.1176/appi.ajp.2010.09091379eng
hcfmusp.relation.referenceIvanova MY, 2007, J CLIN CHILD ADOLESC, V36, P405, DOI 10.1080/15374410701444363eng
hcfmusp.relation.referenceKapur S, 2012, MOL PSYCHIATR, V17, P1174, DOI 10.1038/mp.2012.105eng
hcfmusp.relation.referenceKushki A, 2019, TRANSL PSYCHIAT, V9, DOI 10.1038/s41398-019-0631-2eng
hcfmusp.relation.referenceLee JJ, 2018, NAT GENET, V50, P1112, DOI 10.1038/s41588-018-0147-3eng
hcfmusp.relation.referenceLEZAK MD, 1982, INT J PSYCHOL, V17, P281, DOI 10.1080/00207598208247445eng
hcfmusp.relation.referenceLinzer DA, 2011, J STAT SOFTW, V42, P1, DOI 10.18637/jss.v042.i10eng
hcfmusp.relation.referenceLoeber R, 2012, J AM ACAD CHILD PSY, V51, P1136, DOI 10.1016/j.jaac.2012.08.019eng
hcfmusp.relation.referenceMarquand Andre F, 2016, Biol Psychiatry Cogn Neurosci Neuroimaging, V1, P433eng
hcfmusp.relation.referenceMilham MP, 2017, DEPRESS ANXIETY, V34, P578, DOI 10.1002/da.22627eng
hcfmusp.relation.referenceMiyake A, 2012, CURR DIR PSYCHOL SCI, V21, P8, DOI 10.1177/0963721411429458eng
hcfmusp.relation.referenceMOFFITT TE, 1993, DEV PSYCHOPATHOL, V5, P135, DOI 10.1017/S0954579400004302eng
hcfmusp.relation.referenceMoffitt TE, 1989, DEV PSYCHOPATHOL, V1, P105eng
hcfmusp.relation.referenceMoffitt TE, 2011, P NATL ACAD SCI USA, V108, P2693, DOI 10.1073/pnas.1010076108eng
hcfmusp.relation.referenceNigg JT, 2005, BIOL PSYCHIAT, V57, P1224, DOI 10.1016/j.biopsych.2004.08.025eng
hcfmusp.relation.referenceNowrangi MA, 2014, J NEUROPSYCH CLIN N, V26, P114, DOI 10.1176/appi.neuropsych.12070176eng
hcfmusp.relation.referenceOtero TM, 2014, APPL NEUROPSYCH-CHIL, V3, P205, DOI 10.1080/21622965.2014.897903eng
hcfmusp.relation.referencePandey A, 2018, JAMA PEDIATR, V172, P566, DOI 10.1001/jamapediatrics.2018.0232eng
hcfmusp.relation.referencePennington BF, 1996, J CHILD PSYCHOL PSYC, V37, P51, DOI 10.1111/j.1469-7610.1996.tb01380.xeng
hcfmusp.relation.referenceR Core Team, 2018, R LANG ENV STAT COMP, DOI 10.1007/978-3-540-74686-7eng
hcfmusp.relation.referenceRiccio CA, 2013, APPL NEUROPSYCH-CHIL, V2, P133, DOI 10.1080/21622965.2013.748383eng
hcfmusp.relation.referenceRoberts G, 2016, JAMA PEDIATR, V170, DOI 10.1001/jamapediatrics.2015.4568eng
hcfmusp.relation.referenceRobin X, 2011, BMC BIOINFORMATICS, V12, DOI 10.1186/1471-2105-12-77eng
hcfmusp.relation.referenceROBINS E, 1970, AM J PSYCHIAT, V126, P983, DOI 10.1176/ajp.126.7.983eng
hcfmusp.relation.referenceRobson DA, 2020, PSYCHOL BULL, V146, P324, DOI 10.1037/bul0000227eng
hcfmusp.relation.referenceRueda MR, 2005, DEV NEUROPSYCHOL, V28, P573, DOI 10.1207/s15326942dn2802_2eng
hcfmusp.relation.referenceSalum GA, 2018, SALUD MENT, V41, P249, DOI [10.17711/sm.0185-3325.2018.037, 10.17711/SM.0185-3325.2018.037]eng
hcfmusp.relation.referenceSalum GA, 2015, INT J METH PSYCH RES, V24, P58, DOI 10.1002/mpr.1459eng
hcfmusp.relation.referenceShanmugan S, 2016, AM J PSYCHIAT, V173, P517, DOI 10.1176/appi.ajp.2015.15060725eng
hcfmusp.relation.referenceSiugzdaite R, 2020, CURR BIOL, V30, P1245, DOI 10.1016/j.cub.2020.01.078eng
hcfmusp.relation.referenceSmoller JW, 2013, LANCET, V381, P1371, DOI 10.1016/S0140-6736(12)62129-1eng
hcfmusp.relation.referenceStringaris A, 2013, J ABNORM CHILD PSYCH, V41, P1109, DOI 10.1007/s10802-013-9744-xeng
hcfmusp.relation.referenceVaidya CJ, 2020, J CHILD PSYCHOL PSYC, V61, P51, DOI 10.1111/jcpp.13114eng
hcfmusp.relation.referencevan Buuren S, 2011, J STAT SOFTW, V45, P1eng
hcfmusp.relation.referenceVandierendonck A, 2004, BRIT J PSYCHOL, V95, P57, DOI 10.1348/000712604322779460eng
hcfmusp.relation.referenceWechsler D., 2002, WISC 3 ESCALA INTELIeng
hcfmusp.relation.referenceWhite IR, 2011, STAT MED, V30, P377, DOI 10.1002/sim.4067eng
hcfmusp.relation.referenceWood S, GEN ADDITIVE MIXED Meng
hcfmusp.relation.referenceWray NR, 2018, NAT GENET, V50, P668, DOI 10.1038/s41588-018-0090-3eng
hcfmusp.relation.referenceYOUDEN WJ, 1950, CANCER, V3, P32, DOI 10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3eng
hcfmusp.scopus.lastupdate2024-06-09
relation.isAuthorOfPublication107c1ba9-764d-461e-aa8d-0dee86ca590e
relation.isAuthorOfPublication5edbe58f-e04a-45b0-9880-ef4c58b32c60
relation.isAuthorOfPublicationfb3862ee-3c68-42fa-b08a-2658c28981ee
relation.isAuthorOfPublication587b0a62-5611-4071-ae48-19a46c43b55d
relation.isAuthorOfPublication.latestForDiscovery107c1ba9-764d-461e-aa8d-0dee86ca590e
Arquivos
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/23