Neurophysiological biomarkers of motor improvement from Constraint-Induced Movement Therapy and Robot-Assisted Therapy in participants with stroke

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSIMIS, Marcel
dc.contributor.authorTHIBAUT, Aurore
dc.contributor.authorIMAMURA, Marta
dc.contributor.authorBATTISTELLA, Linamara Rizzo
dc.contributor.authorFREGNI, Felipe
dc.date.accessioned2023-10-30T14:37:07Z
dc.date.available2023-10-30T14:37:07Z
dc.date.issued2023
dc.description.abstractBackgroundThe mechanism of stroke recovery is related to the reorganization of cerebral activity that can be enhanced by rehabilitation therapy. Two well established treatments are Robot-Assisted Therapy (RT) and Constraint-Induced Movement Therapy (CIMT), however, it is unknown whether there is a difference in the neuroplastic changes induced by these therapies, and if the modifications are related to motor improvement. Therefore, this study aims to identify neurophysiological biomarkers related to motor improvement of participants with chronic stroke that received RT or CIMT, and to test whether there is a difference in neuronal changes induced by these two therapies.MethodsThis study included participants with chronic stroke that took part in a pilot experiment to compare CIMT vs. RT. Neurophysiological evaluations were performed with electroencephalography (EEG) and transcranial magnetic stimulation (TMS), pre and post rehabilitation therapy. Motor function was measured by the Wolf Motor Function Test (WMFT) and Fugl-Meyer Assessment Upper Limb (FMA-UL).ResultsTwenty-seven participants with chronic stroke completed the present study [mean age of 58.8 years (SD +/- 13.6), mean time since stroke of 18.2 months (SD +/- 9.6)]. We found that changes in motor threshold (MT) and motor evoked potential (MEP) in the lesioned hemisphere have a positive and negative correlation with WMFT improvement, respectively. The absolute change in alpha peak in the unlesioned hemisphere and the absolute change of the alpha ratio (unlesioned/lesioned hemisphere) is negatively correlated with WMFT improvement. The decrease of EEG power ratio (increase in the lesioned hemisphere and decrease in the unlesioned hemisphere) for high alpha bandwidths is correlated with better improvement in WMFT. The variable ""type of treatment (RT or CIMT)"" was not significant in the models.ConclusionOur results suggest that distinct treatments (RT and CIMT) have similar neuroplastic mechanisms of recovery. Moreover, motor improvements in participants with chronic stroke are related to decreases of cortical excitability in the lesioned hemisphere measured with TMS. Furthermore, the balance of both EEG power and EEG alpha peak frequency in the lesioned hemisphere is related to motor improvement.eng
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipUSP NAP (Nucleos de Apoio a Pesquisa) University of So Paulo
dc.description.sponsorshipCenter for Advanced Studies in Rehabilitation-CEAR of the Hospital das Clinicas da Faculdade de Medicina da Universidade de So Paulo-HCFMUSP
dc.description.sponsorshipFundaco de Amparo a Pesquisa do Estado de So Paulo [2017/12943-8]
dc.identifier.citationFRONTIERS IN HUMAN NEUROSCIENCE, v.17, article ID 1188806, 9p, 2023
dc.identifier.doi10.3389/fnhum.2023.1188806
dc.identifier.issn1662-5161
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/56109
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Human Neuroscience
dc.rightsopenAccesseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subjectstrokeeng
dc.subjectpredictorseng
dc.subjectelectroencephalographyeng
dc.subjectpower analysiseng
dc.subjectrobot-assisted therapyeng
dc.subjectconstraint-induced movement therapyeng
dc.subject.othersensorimotor cortex activationeng
dc.subject.otherquantitative eegeng
dc.subject.otherrehabilitationeng
dc.subject.otherpatienteng
dc.subject.otheradultseng
dc.subject.otherrhythmeng
dc.subject.othertrialeng
dc.subject.wosNeuroscienceseng
dc.subject.wosPsychologyeng
dc.titleNeurophysiological biomarkers of motor improvement from Constraint-Induced Movement Therapy and Robot-Assisted Therapy in participants with strokeeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryBélgica
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisobe
hcfmusp.affiliation.countryisous
hcfmusp.author.externalTHIBAUT, Aurore:Univ Liege, Coma Sci Grp, GIGA Consciousness, Liege, Belgium
hcfmusp.author.externalFREGNI, Felipe:Harvard Med Sch, Spaulding Rehabil Hosp, Neuromodulat Ctr, Boston, MA USA
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcMARCEL SIMIS
hcfmusp.contributor.author-fmusphcMARTA IMAMURA
hcfmusp.contributor.author-fmusphcLINAMARA RIZZO BATTISTELLA
hcfmusp.description.articlenumber1188806
hcfmusp.description.volume17
hcfmusp.origemWOS
hcfmusp.origem.pubmed37780964
hcfmusp.origem.scopus2-s2.0-85173090743
hcfmusp.origem.wosWOS:001075091600001
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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