Loss of an eye to mucormycosis following corticosteroid therapy for COVID-19

Mucormycosis is a rare, sometimes severe fungal infection that has emerged as a possible complication of COVID-19. We report a case of a non-diabetic, apparently immunocompetent patient diagnosed with rhino-orbital-cerebral mucormycosis shortly after COVID-19 treatment with dexamethasone. The patient received optimized systemic antifungal therapy and extensive surgical treatment. So far, four months after the last hospital discharge, the patient has been in good general condition. This case is a dramatic reminder that beneficial corticosteroid therapy in general inevitably carries a risk of opportunistic infection, and corticosteroid therapy for COVID-19 risks orbital-rhinocerebral mucormycosis that clinicians should watch for with vigilance. © 2021 The Author(s).

Palavras-chave

Immunocompetence, Orbit, SARS-CoV-2

URI

https://observatorio.fm.usp.br/handle/OPI/51862

Referências

Cornely, OA, Alastruey-Izquierdo, A, Arenz, D, Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium (2019) Lancet Infect Dis, 19 (12), pp. e405-e421. , http://dx.doi.org/10.1016/S1473-3099(19)30312-3, PMid:31699664
Raut, A, Huy, NT., Rising incidence of mucormycosis in patients with COVID-19: another challenge for India amidst the second wave? (2021) Lancet Respir Med, 9 (8), p. e77. , http://dx.doi.org/10.1016/S2213-2600(21)00265-4, PMid:34090607
Patel, A, Agarwal, R, Rudramurthy, SM, Multicenter epidemiologic study of coronavirus disease-associated mucormycosis, India (2021) Emerg Infect Dis, 27 (9), pp. 2349-2359. , http://dx.doi.org/10.3201/eid2709.210934, PMid:34087089
John, TM, Jacob, CN, Kontoyiannis, DP., When uncontrolled diabetes mellitus and severe COVID-19 converge: the perfect storm for mucormycosis (2021) J Fungi, 7 (4), p. 298. , http://dx.doi.org/10.3390/jof7040298, PMid:33920755
Pasero, D, Sanna, S, Liperi, C, A challenging complication following SARS-CoV-2 infection: a case of pulmonary mucormycosis (2021) Infection, 49 (5), pp. 1055-1060. , http://dx.doi.org/10.1007/s15010-020-01561-x, PMid:33331988

Coleções

Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/45
Artigos e Materiais de Revistas Científicas - LIM/48
Artigos e Materiais de Revistas Científicas - LIM/62

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