Influence of antidepressant drugs on DNA methylation of ion channels genes in blood cells of psychiatric patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNASCIMENTO, Larissa Vilela
dc.contributor.authorNETO, Francisco Lotufo
dc.contributor.authorMOREIRA, Dalmo Antonio Ribeiro
dc.contributor.authorCERUTTI, Virginia Braga
dc.contributor.authorTHUROW, Helena Strelow
dc.contributor.authorBASTOS, Gisele Medeiros
dc.contributor.authorFERREIRA, Eric Batista
dc.contributor.authorHIRATA, Rosario Dominguez Crespo
dc.contributor.authorHIRATA, Mario Hiroyuki
dc.date.accessioned2022-08-12T17:14:56Z
dc.date.available2022-08-12T17:14:56Z
dc.date.issued2022
dc.description.abstractAim: This study investigated the influence of antidepressant drugs on methylation status of KCNE1, KCNH2 and SCN5A promoters and ECG parameters in adult psychiatric patients. Materials & methods: Electrocardiographic evaluation (24 h) and blood samples were obtained from 34 psychiatric patients before and after 30 days of antidepressant therapy. Methylation of promoter CpG sites of KCNE1, KCNH2 and SCN5A was analyzed by pyrosequencing. Results: Three CpG and four CpG sites of KCNE1 and SCN5A, respectively, had increased % methylation after treatment. Principal component analysis showed correlations of the methylation status with electrocardiographic variables, antidepressant doses and patient age. Conclusion: Short-term treatment with antidepressant drugs increase DNA methylation in KCNE1 and SCN5A promoters, which may induce ECG alterations in psychiatric patients.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFAPESP [2016/12899-6]
dc.description.sponsorshipCNPq [302733/2016-7]
dc.description.sponsorshipCAPES [Code 001]
dc.identifier.citationEPIGENOMICS, v.14, n.14, p.851-864, 2022
dc.identifier.doi10.2217/epi-2022-0089
dc.identifier.eissn1750-192X
dc.identifier.issn1750-1911
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/48553
dc.language.isoeng
dc.publisherFUTURE MEDICINE LTDeng
dc.relation.ispartofEpigenomics
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright FUTURE MEDICINE LTDeng
dc.subjectantidepressant drugseng
dc.subjectcardiac arrhythmiaseng
dc.subjectDNA methylationeng
dc.subjectpharmacoepigeneticseng
dc.subjectpyrosequencingeng
dc.subject.othertorsades-de-pointeseng
dc.subject.otherqt-prolongationeng
dc.subject.otherriskeng
dc.subject.otherepigeneticseng
dc.subject.othertoolseng
dc.subject.otherfocuseng
dc.subject.wosGenetics & Heredityeng
dc.titleInfluence of antidepressant drugs on DNA methylation of ion channels genes in blood cells of psychiatric patientseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalNASCIMENTO, Larissa Vilela:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalMOREIRA, Dalmo Antonio Ribeiro:Inst Dante Pazzanese Cardiol, Dept Electrophysiol & Cardiac Arrhythmias, BR-04012909 Sao Paulo, Brazil
hcfmusp.author.externalCERUTTI, Virginia Braga:Inst Dante Pazzanese Cardiol, Dept Electrophysiol & Cardiac Arrhythmias, BR-04012909 Sao Paulo, Brazil
hcfmusp.author.externalTHUROW, Helena Strelow:Real & Benemerita Assoc Portuguesa Beneficiencia, Dept Teaching & Res, BR-01323001 Sao Paulo, Brazil
hcfmusp.author.externalBASTOS, Gisele Medeiros:Real & Benemerita Assoc Portuguesa Beneficiencia, Dept Teaching & Res, BR-01323001 Sao Paulo, Brazil
hcfmusp.author.externalFERREIRA, Eric Batista:Univ Fed Alfenas, Inst Exact Sci, BR-37130001 Alfenas, Brazil
hcfmusp.author.externalHIRATA, Rosario Dominguez Crespo:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalHIRATA, Mario Hiroyuki:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508000 Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcFRANCISCO LOTUFO NETO
hcfmusp.description.beginpage851
hcfmusp.description.endpage864
hcfmusp.description.issue14
hcfmusp.description.volume14
hcfmusp.origemWOS
hcfmusp.origem.pubmed35818955
hcfmusp.origem.scopus2-s2.0-85135198124
hcfmusp.origem.wosWOS:000823053000001
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
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