Cardiovascular autonomic dysfunction in non-obese diabetic mice

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMORAES, Oscar A.
dc.contributor.authorCOLUCCI, Juliana A.
dc.contributor.authorSOUZA, Leandro E.
dc.contributor.authorSCAPINI, Katia B.
dc.contributor.authorMORAES-SILVA, Ivana C.
dc.contributor.authorMOSTARDA, Cristiano
dc.contributor.authorANGELIS, Katia De
dc.contributor.authorCASARINI, Dulce E.
dc.contributor.authorIRIGOYEN, Maria Claudia
dc.date.accessioned2014-01-28T22:33:00Z
dc.date.available2014-01-28T22:33:00Z
dc.date.issued2013
dc.description.abstractIt is known that diabetes is associated with autonomic dysfunction; however, data about autonomic function in non-obese diabetic mice (NOD) remain scarce. We evaluated the autonomic profile of NOD mice. Female mice, 24-28 week old, were divided in two groups: NOD (n = 6) and control (n = 6, Swiss mice). NOD mice with glycemia >= 300 mg/dl were used. Heart rate variability (HRV) and arterial pressure variability (APV) in time and frequency domains, symbolic analysis of heart rate (HR) and baroreflex sensitivity were evaluated. HR and arterial pressure (AP) were similar between the groups; however, HRV (total variance of RR interval: NOD = 21.07 +/- 3.75 vs. C = 42.02 +/- 6.54 ms(2)) and the vagal modulation index RMSSD were lower in NOD group (4.01 +/- 032 vs. 8.28 +/- 0.97 ms). Moreover, the absolute and normalized low-frequency (LF) components were also enhanced in NOD (normalized = 61.0 +/- 4.0%) as compared to control mice (normalized = 20.0 +/- 4.0%). Both the absolute and normalized high-frequency (HF) components were lower in NOD (normalized = 39.0 +/- 4.0%) when compared to the control group (normalized = 80.0 +/- 4.0). In the symbolic analysis the 0V pattern, an indication of sympathetic activity, was higher in NOD and 2LV pattern, an indication of parasympathetic activity, was lower in the NOD than in the control group. Both bradycardic and tachycardic responses were decreased in NOD (3.01 +/- 0.72 vs. 4.54 +/- 0.36 bpm/mm Hg and 2.49 +/- 031 vs. C = 3.43 +/- 033 bpm/mm Hg) when compared to the control group. Correlation analysis showed negative correlations between vagal indexes (RMSSD, %HF and 2LV) and glycemic levels. In conclusion, NOD mice develop severe diabetes correlated with autonomic dysfunction.
dc.description.indexMEDLINE
dc.identifier.citationAUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, v.177, n.2, p.143-147, 2013
dc.identifier.doi10.1016/j.autneu.2013.03.011
dc.identifier.issn1566-0702
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4539
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofAutonomic Neuroscience-Basic & Clinical
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectDiabetes mellitus
dc.subjectAutonomic nervous system
dc.subjectBaroreflex
dc.subjectMice
dc.subjectInbred NOD
dc.subject.otherheart-rate-variability
dc.subject.otherrenin-angiotensin system
dc.subject.othernod mice
dc.subject.otherbaroreflex sensitivity
dc.subject.otherarterial-pressure
dc.subject.otherreflex control
dc.subject.otherrats
dc.subject.otherneuropathy
dc.subject.othermodulation
dc.subject.othermodel
dc.subject.wosNeurosciences
dc.titleCardiovascular autonomic dysfunction in non-obese diabetic mice
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalMORAES, Oscar A.:Univ Sao Paulo FMUSP, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403000 Sao Paulo, Brazil; Nove de Julho Univ, Sao Paulo, Brazil
hcfmusp.author.externalCOLUCCI, Juliana A.:Univ Fed Sao Paulo, Dept Med, Div Nephrol, Sao Paulo, Brazil
hcfmusp.author.externalMORAES-SILVA, Ivana C.:Univ Sao Paulo FMUSP, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403000 Sao Paulo, Brazil
hcfmusp.author.externalANGELIS, Katia De:Nove de Julho Univ, Sao Paulo, Brazil
hcfmusp.author.externalCASARINI, Dulce E.:Univ Fed Sao Paulo, Dept Med, Div Nephrol, Sao Paulo, Brazil
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcLEANDRO EZIQUIEL DE SOUZA
hcfmusp.contributor.author-fmusphcKATIA BILHAR SCAPINI
hcfmusp.contributor.author-fmusphcCRISTIANO TEIXEIRA MOSTARDA
hcfmusp.contributor.author-fmusphcMARIA CLAUDIA COSTA IRIGOYEN
hcfmusp.description.beginpage143
hcfmusp.description.endpage147
hcfmusp.description.issue2
hcfmusp.description.volume177
hcfmusp.origemWOS
hcfmusp.origem.pubmed23622812
hcfmusp.origem.scopus2-s2.0-84883773139
hcfmusp.origem.wosWOS:000325665700011
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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