Association of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSIQUEIRA, Erika Rabelo Forte de
dc.contributor.authorPEREIRA, Luciano Beltrao
dc.contributor.authorSTEFANO, Jose Tadeu
dc.contributor.authorPATENTE, Thiago
dc.contributor.authorCAVALEIRO, Ana Mercedes
dc.contributor.authorVASCONCELOS, Luydson Richardson Silva
dc.contributor.authorCARMO, Rodrigo Feliciano
dc.contributor.authorPEREIRA, Leila Maria Moreira Beltrao
dc.contributor.authorCARRILHO, Flair Jose
dc.contributor.authorCORREA-GIANNELLA, Maria Lucia
dc.contributor.authorOLIVEIRA, Claudia P.
dc.date.accessioned2015-08-14T15:37:33Z
dc.date.available2015-08-14T15:37:33Z
dc.date.issued2015
dc.description.abstractBackground: Given the important contribution of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system to the generation of reactive oxygen species induced by hepatitis C virus (HCV), we investigated two single nucleotide polymorphisms (SNPs) in the putative regulatory region of the genes encoding NADPH oxidase 4 catalytic subunit (NOX4) and its regulatory subunit p22phox (CYBA) and their relation with metabolic and histological variables in patients with HCV. Methods: One hundred seventy eight naive HCV patients (49.3% male; 65% HCV genotype 1) with positive HCV RNA were genotyped using specific primers and fluorescent-labeled probes for SNPs rs3017887 in NOX4 and -675 T -> A in CYBA. Results: No association was found between the genotype frequencies of NOX4 and CYBA SNPs and inflammation scores or fibrosis stages in the overall population. The presence of the CA + AA genotypes of the NOX4 SNP was nominally associated with a lower alanine aminotransferase (ALT) concentration in the male population (CA + AA = 72.23 +/- 6.34 U/L versus CC = 100.22 +/- 9.85; mean +/- SEM; P = 0.05). The TT genotype of the CYBA SNP was also nominally associated with a lower ALT concentration in the male population (TT = 84.01 +/- 6.77 U/L versus TA + AA = 109.67 +/- 18.37 U/L; mean +/- SEM; P = 0.047). The minor A-allele of the NOX4 SNP was inversely associated with the frequency of metabolic syndrome (MS) in the male population (odds ratio (OR): 0.15; 95% confidence interval (CI): 0.03 to 0.79; P = 0.025). Conclusions: The results suggest that the evaluated NOX4 and CYBA SNPs are not direct genetic determinants of fibrosis in HCV patients, but nevertheless NOX4 rs3017887 SNP could indirectly influence fibrosis susceptibility due to its inverse association with MS in male patients.
dc.description.indexMEDLINE
dc.identifier.citationEUROPEAN JOURNAL OF MEDICAL RESEARCH, v.20, article ID 45, 6p, 2015
dc.identifier.doi10.1186/s40001-015-0136-2
dc.identifier.eissn2047-783X
dc.identifier.issn0949-2321
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9773
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofEuropean Journal of Medical Research
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectHepatitis C
dc.subjectNADPH oxidase 4 polymorphisms
dc.subjectMetabolic syndrome
dc.subject.otheroxidative stress
dc.subject.otherhepatocellular-carcinoma
dc.subject.othervirus-infection
dc.subject.otherprotein
dc.subject.otherdisease
dc.subject.otherplasma
dc.subject.otherhealth
dc.subject.otherrisk
dc.subject.wosMedicine, Research & Experimental
dc.titleAssociation of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalVASCONCELOS, Luydson Richardson Silva:Liver Inst Pernambuco, BR-282 Recife, PE, Brazil
hcfmusp.author.externalCARMO, Rodrigo Feliciano:Fed Univ Sao Francisco Valley, Coll Pharmaceut Sci, Petrolina, PE, Brazil
hcfmusp.author.externalPEREIRA, Leila Maria Moreira Beltrao:Univ Pernambuco, Sch Med, Dept Gastroenterol, BR-1235 Pernambuco, Brazil; Liver Inst Pernambuco, BR-282 Recife, PE, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcERIKA RABELO FORTE DE SIQUEIRA
hcfmusp.contributor.author-fmusphcLUCIANO BELTRAO PEREIRA
hcfmusp.contributor.author-fmusphcJOSE TADEU STEFANO
hcfmusp.contributor.author-fmusphcTHIAGO ANDRADE PATENTE
hcfmusp.contributor.author-fmusphcANA MERCEDES DE SOUSA CAVALEIRO
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.contributor.author-fmusphcMARIA LUCIA CARDILLO CORREA GIANNELLA
hcfmusp.contributor.author-fmusphcCLAUDIA PINTO MARQUES SOUZA DE OLIVEIRA
hcfmusp.description.articlenumber45
hcfmusp.description.volume20
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84926188018
hcfmusp.origem.wosWOS:000352078000001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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