Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMIGUITA, Karen
dc.contributor.authorCORDEIRO, Quirino
dc.contributor.authorSHAVITT, Roseli Gedanke
dc.contributor.authorMIGUEL, Eurpedes Constantino
dc.contributor.authorVALLADA, Homero
dc.date.accessioned2017-11-27T16:34:32Z
dc.date.available2017-11-27T16:34:32Z
dc.date.issued2011
dc.description.abstractIn the present paper, we investigated the 5HTTLPR and STin2 polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4), the G861C polymorphism (rs6296) of the serotonin receptor 1D beta (HTR1B), the T102C (rs6113) and C516T (rs6305) polymorphisms of the serotonin receptor gene subtype 2A (HTR2A), the DAT UTR, DAT intron 8 and DAT intron 14 of the dopamine transporter gene (SLC6A3), the Val-158-Met (rs4680) polymorphism of the COMT and the silent mutation G1287A (rs5569) in the norepinephrine transporter gene (SLC6A2). We genotyped 41 obsessive-compulsive disorder (OCD) outpatients, classified as good-responders (n=27) and poor-responders (n=14) to treatment with clomipramine according to the Yale Brown Obsessive-Compulsive Scale (YBOCS). Patients who achieved a reduction in symptoms of 40% or more in YBOCS after 14 weeks of treatment were considered good-responders. Genotypes and alleles distribution of the investigated polymorphisms were compared between both groups. We did not find association between the studied polymorphisms and clomipramine response in our sample.
dc.description.indexMEDLINE
dc.description.sponsorshipCAPES [8817]
dc.description.sponsorshipFAPESP [99/01548-0, 99/12205-7]
dc.identifier.citationARQUIVOS DE NEURO-PSIQUIATRIA, v.69, n.2B, p.283-287, 2011
dc.identifier.issn0004-282X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23409
dc.language.isoeng
dc.publisherASSOC ARQUIVOS NEURO- PSIQUIATRIA
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsopenAccess
dc.rights.holderCopyright ASSOC ARQUIVOS NEURO- PSIQUIATRIA
dc.subjectOCD
dc.subjectclomipramine
dc.subjectserotonin receptor
dc.subjectserotonin transporter
dc.subjectdopamine transporter
dc.subjectnorepinephrine transporter
dc.subject.otherobsessive-compulsive disorder
dc.subject.otherserotonin transporter gene
dc.subject.otherreceptor gene
dc.subject.otherreuptake inhibitors
dc.subject.otherallelic variation
dc.subject.otherdopamine
dc.subject.otherregion
dc.subject.othervntr
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.titleAssociation study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalMIGUITA, Karen:Univ Sao Paulo, Sch Med, Inst Psychiat, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo, Brazil; Adolfo Lutz Inst, Sao Paulo, Brazil
hcfmusp.citation.scopus20
hcfmusp.contributor.author-fmusphcQUIRINO CORDEIRO JUNIOR
hcfmusp.contributor.author-fmusphcROSELI GEDANKE SHAVITT
hcfmusp.contributor.author-fmusphcEURIPEDES CONSTANTINO MIGUEL FILHO
hcfmusp.contributor.author-fmusphcHOMERO PINTO VALLADA FILHO
hcfmusp.description.beginpage283
hcfmusp.description.endpage287
hcfmusp.description.issue2B
hcfmusp.description.volume69
hcfmusp.origemWOS
hcfmusp.origem.pubmed21625751
hcfmusp.origem.scopus2-s2.0-79958863690
hcfmusp.origem.wosWOS:000291029400003
hcfmusp.publisher.citySAO PAULO SP
hcfmusp.publisher.countryBRAZIL
hcfmusp.relation.referenceAmerican Psychiatric Association, 1994, DIAGN STAT MAN MENT
hcfmusp.relation.referenceGreenwood TA, 2003, GENOMICS, V82, P511, DOI 10.1016/S0888-7543(03)00142-3
hcfmusp.relation.referenceGuindalini C, 2006, P NATL ACAD SCI USA, V103, P4552, DOI 10.1073/pnas.0504789103
hcfmusp.relation.referencePigott TA, 1999, J CLIN PSYCHIAT, V60, P101
hcfmusp.relation.referenceHeils A, 1996, J NEUROCHEM, V66, P2621
hcfmusp.relation.referenceJonsson EG, 1998, PSYCHIAT RES, V79, P1, DOI 10.1016/S0165-1781(98)00027-4
hcfmusp.relation.referenceDaniels JK, 1996, AM J PSYCHIAT, V153, P268
hcfmusp.relation.referenceVANDENBERGH DJ, 1992, GENOMICS, V14, P1104, DOI 10.1016/S0888-7543(05)80138-7
hcfmusp.relation.referenceCordeiro Q, 2009, REV BRAS PSIQUIATR, V31, P154, DOI 10.1590/S1516-44462009000200013
hcfmusp.relation.referencede Leon J, 2008, CLIN LAB MED, V28, P599, DOI 10.1016/j.cll.2008.05.003
hcfmusp.relation.referenceMacKenzie A, 1999, P NATL ACAD SCI USA, V96, P15251, DOI 10.1073/pnas.96.26.15251
hcfmusp.relation.referenceBillett EA, 1997, MOL PSYCHIATR, V2, P403, DOI 10.1038/sj.mp.4000257
hcfmusp.relation.referenceARRANZ M, 1995, LANCET, V346, P281, DOI 10.1016/S0140-6736(95)92168-0
hcfmusp.relation.referenceCavallini MC, 1998, PSYCHIAT RES, V77, P97
hcfmusp.relation.referenceDenys D, 2007, J CLIN PSYCHIAT, V68, P747
hcfmusp.relation.referenceDi Bella D., 2002, Pharmacogenomics Journal, V2, P176, DOI 10.1038/sj.tpj.6500090
hcfmusp.relation.referenceMcDougle CJ, 1998, MOL PSYCHIATR, V3, P270, DOI 10.1038/sj.mp.4000391
hcfmusp.relation.referenceMundo E, 2000, AM J PSYCHIAT, V157, P1160, DOI 10.1176/appi.ajp.157.7.1160
hcfmusp.relation.referenceShavitt Roseli G, 2006, Compr Psychiatry, V47, P276, DOI 10.1016/j.comppsych.2005.09.001
hcfmusp.relation.referenceSilva MA, 2005, REV MED CHILE, V133, P1392, DOI 10.4067/S0034-98872005001100017
hcfmusp.relation.referenceSpina E, 1997, EUR J CLIN PHARMACOL, V51, P395, DOI 10.1007/s002280050220
hcfmusp.relation.referenceSTAHL SM, 2003, J CLIN PSYCHIAT, V64, P137
hcfmusp.relation.referenceWARREN JT, 1993, HUM MOL GENET, V2, P338, DOI 10.1093/hmg/2.3.338
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