Haplotype diversity in mitochondrial DNA hypervariable region in a population of southeastern Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFRIDMAN, C.
dc.contributor.authorGONZALEZ, R. S.
dc.contributor.authorPEREIRA, A. C.
dc.contributor.authorCARDENA, M. M. S. G.
dc.date.accessioned2015-02-06T19:43:28Z
dc.date.available2015-02-06T19:43:28Z
dc.date.issued2014
dc.description.abstractBrazilian population derives from Native Amerindians, Europeans, and Africans. Southeastern Brazil is the most populous region of the country. The present study intended to characterize the maternal genetic ancestry of 290 individuals from southeastern (Brazil) population. Thus, we made the sequencing of the three hypervariable regions (HV1, HV2, and HV3) of the mitochondrial DNA (mtDNA). The statistical analyses were made using Arlequin software, and the median-joining haplotype networks were generated using Network software. The analysis of three hypervariable regios showed 230 (79.3 %) unique haplotypes and the most common haplotype was ""263G"" carried by 12 (4.1 %) individuals. The strikingly high variability generated by intense gene flow is mirrored in a high sequence diversity (0.9966 +/- 0.0010), and the probability of two random individuals showing identical mtDNA haplotypes were 0.0068. The analysis of haplogroup distribution revealed that 36.9 % (n = 107) presented Amerindian haplogroups, 35.2 % (n = 102) presented African haplogroups, 27.6 % (n = 80) presented European haplogroups, and one (0.3 %) individual presented East Asian haplogroup, evidencing that the southeastern population is extremely heterogeneous and the coexistence of matrilineal lineages with three different phylogeographic origins. The genetic diversity found in the mtDNA control region in the southeastern Brazilian population reinforces the importance of increased national database in order to be important and informative in forensic cases.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)
dc.description.sponsorshipHC-LIM [(LIM40)/FMUSP]
dc.identifier.citationINTERNATIONAL JOURNAL OF LEGAL MEDICINE, v.128, n.4, p.589-593, 2014
dc.identifier.doi10.1007/s00414-014-1023-z
dc.identifier.eissn1437-1596
dc.identifier.issn0937-9827
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8474
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofInternational Journal of Legal Medicine
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subjectMitochondrial DNA
dc.subjectControl region
dc.subjectHaplogroup
dc.subjectBrazil
dc.subject.othermtdna control region
dc.subject.otherdata quality-control
dc.subject.othernucleotide variability
dc.subject.otherconsistent treatment
dc.subject.otherlength variants
dc.subject.otheramazon region
dc.subject.otherhv-i
dc.subject.othersequences
dc.subject.otherancestry
dc.subject.othergenetics
dc.subject.wosMedicine, Legal
dc.titleHaplotype diversity in mitochondrial DNA hypervariable region in a population of southeastern Brazil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalGONZALEZ, R. S.:Univ Sao Paulo, Dept Legal Med Eth & Occupat Hlth, Sch Med, BR-05405000 Sao Paulo, Brazil
hcfmusp.citation.scopus14
hcfmusp.contributor.author-fmusphcCINTIA FRIDMAN RAVE
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.contributor.author-fmusphcMARI MAKI SIRIA GODOY CARDENA
hcfmusp.description.beginpage589
hcfmusp.description.endpage593
hcfmusp.description.issue4
hcfmusp.description.volume128
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84904384130
hcfmusp.origem.wosWOS:000340070800002
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAlves-Silva J, 2000, AM J HUM GENET, V67, P444, DOI 10.1086/303004
hcfmusp.relation.referenceANDERSON S, 1981, NATURE, V290, P457, DOI 10.1038/290457a0
hcfmusp.relation.referenceAndrews RM, 1999, NAT GENET, V23, P147
hcfmusp.relation.referenceBandelt HJ, 1999, MOL BIOL EVOL, V16, P37
hcfmusp.relation.referenceBandelt HJ, 2012, INT J LEGAL MED, V126, P901, DOI 10.1007/s00414-012-0762-y
hcfmusp.relation.referenceBandelt HJ, 2008, INT J LEGAL MED, V122, P11, DOI 10.1007/s00414-006-0151-5
hcfmusp.relation.referenceBarbosa ABG, 2008, J FORENSIC SCI, V53, P142, DOI 10.1111/j.1556-4029.2007.00619.x
hcfmusp.relation.referenceBernardo S, 2014, MOL BIOL REP, V41, P1945, DOI 10.1007/s11033-014-3041-9
hcfmusp.relation.referenceBethell L, 1997, AM LATINA COLONIAL, P129
hcfmusp.relation.referenceCardena MMSG, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062005
hcfmusp.relation.referenceCarracedo A, 2000, FORENSIC SCI INT, V110, P79, DOI 10.1016/S0379-0738(00)00161-4
hcfmusp.relation.referenceDESAINTPIERRE M, 2012, PLOS ONE, V0007
hcfmusp.relation.referenceExcoffier L, 2005, EVOL BIOINFORM, V1, P47
hcfmusp.relation.referenceFeio-dos-Santos AC, 2006, FORENSIC SCI INT, V164, P276, DOI 10.1016/j.forsciint.2005.12.032
hcfmusp.relation.referenceGILES RE, 1980, P NATL ACAD SCI-BIOL, V77, P6715, DOI 10.1073/pnas.77.11.6715
hcfmusp.relation.referenceGuimaraes CM, 1996, LIBERDADE FIO HIST Q
hcfmusp.relation.referenceHedman M, 2007, FORENSIC SCI INT, V172, P171, DOI 10.1016/j.forsciint.2006.09.012
hcfmusp.relation.referenceIBGE - Instituto Brasileiro de Geografia e Estatistica, 2007, CENS DEM CONT POP 20, V1, P18
hcfmusp.relation.referenceIngman M, 2000, NATURE, V408, P708
hcfmusp.relation.referenceJin HJ, 2006, FORENSIC SCI INT, V158, P125, DOI 10.1016/j.forsciint.2005.03.026
hcfmusp.relation.referenceLee H, 2006, INT J LEGAL MED, V120, P5, DOI 10.1007/s00414-005-0005-6
hcfmusp.relation.referenceLutz S, 1998, INT J LEGAL MED, V111, P67, DOI 10.1007/s004140050117
hcfmusp.relation.referenceMarrero AR, 2005, AM J HUM BIOL, V17, P496, DOI 10.1002/ajhb.20404
hcfmusp.relation.referenceMILLER SA, 1988, NUCLEIC ACIDS RES, V16, P1215, DOI 10.1093/nar/16.3.1215
hcfmusp.relation.referenceMitchell SL, 2014, HUM GENET
hcfmusp.relation.referenceMITOMAP, HUM MIT GEN DAT
hcfmusp.relation.referencePalencia L, 2010, INT J LEGAL MED, V124, P331, DOI 10.1007/s00414-010-0464-2
hcfmusp.relation.referencePaneto GG, 2011, MITOCHONDRION, V11, P296, DOI 10.1016/j.mito.2010.12.010
hcfmusp.relation.referenceParson W, 1998, INT J LEGAL MED, V111, P124, DOI 10.1007/s004140050132
hcfmusp.relation.referenceParson W, 2007, FORENSIC SCI INT-GEN, V1, P88, DOI 10.1016/j.fsigen.2007.01.018
hcfmusp.relation.referencePena SDJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017063
hcfmusp.relation.referencePrieto L, 2011, FORENSIC SCI INT-GEN, V5, P146, DOI 10.1016/j.fsigen.2010.10.013
hcfmusp.relation.referenceRibeiro-dos-Santos AKC, 2007, FORENSIC SCI INT, V167, P77, DOI 10.1016/j.forsciint.2005.12.033
hcfmusp.relation.referenceSalas A, 2004, AM J HUM GENET, V74, P454, DOI 10.1086/382194
hcfmusp.relation.referenceSalas A, 2005, BIOCHEM BIOPH RES CO, V335, P891, DOI 10.1016/j.bbrc.2005.07.161
hcfmusp.relation.referenceSalzano FM, 2002, THESIS
hcfmusp.relation.referenceSalzano FM, 1967, POPULACOES BRASILEIR
hcfmusp.relation.referencevan Oven M, 2009, HUM MUTAT, V30, pE386, DOI 10.1002/humu.20921
hcfmusp.relation.referenceWilson MR, 2002, FORENSIC SCI INT, V129, P35, DOI 10.1016/S0379-0738(02)00206-2
hcfmusp.relation.referenceYao YG, 2004, FORENSIC SCI INT, V141, P1, DOI 10.1016/j.forsciint.2003.12.004
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