Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorASSONE, Tatiane
dc.contributor.authorMALTA, Fernanda M.
dc.contributor.authorBAKKOUR, Sonia
dc.contributor.authorMONTALVO, Leilani
dc.contributor.authorPAIVA, Arthur M.
dc.contributor.authorSMID, Jerusa
dc.contributor.authorOLIVEIRA, Augusto Cesar Penalva de
dc.contributor.authorGONCALVES, Fernanda de Toledo
dc.contributor.authorLUIZ, Olinda do Carmo
dc.contributor.authorFONSECA, Luiz Augusto M.
dc.contributor.authorNORRIS, Philip J.
dc.contributor.authorCASSEB, Jorge
dc.date.accessioned2018-05-08T14:45:35Z
dc.date.available2018-05-08T14:45:35Z
dc.date.issued2018
dc.description.abstractIntroduction: Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. Methods: 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases ""Emilio Ribas"" (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016. The subjects were classified according to their neurological status into two groups: Group 1 (160 asymptomatic individuals) and Group 2 (87 HAM/TSP patients). Samples were tested for spontaneous lymphocyte proliferation (LPA) and HTLV-1 proviral load (PVL) and for IFN-lambda 4, HLA-C and KIR genotypes using qPCR. Results: We found associations between LPA (p = 0.0001) with HAM/TSP and confirmed the IFN-lambda 4 polymorphism rs8099917, allele GG, as a protective factor using a recessive model (OR = 3.22, CI = 1.10-9.47). Polymorphisms in HLA-C and KIR alleles were not associated with risk of developing HAM/TSP. Conclusion: We demonstrated that age, LPA and an IFN-lambda 4 polymorphism were associated with progression to HAM/TSP. Understanding HAM/TSP pathogenesis can provide important markers of prognostic value for clinical management, and contribute to the discovery of new therapeutic interventions in the future.
dc.description.indexMEDLINE
dc.description.sponsorshipCNPq [134001/2011-7]
dc.description.sponsorshipFAPESP [2012/23397-0, 2014/22827-7]
dc.identifier.citationVIRUS RESEARCH, v.244, Special Issue, p.71-74, 2018
dc.identifier.doi10.1016/j.virusres.2017.11.010
dc.identifier.eissn1872-7492
dc.identifier.issn0168-1702
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/26589
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofVirus Research
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectPolymorphisms
dc.subjectInterferons
dc.subjectHTLV-1
dc.subjectHLA antigens
dc.subject.othermyelopathy/tropical spastic paraparesis
dc.subject.othervirus type-i
dc.subject.otherhtlv-1 proviral load
dc.subject.othercd8(+) t-cells
dc.subject.otherreal-time pcr
dc.subject.othertype-1 htlv-1
dc.subject.otherinfection
dc.subject.otherpathogenesis
dc.subject.otherdisease
dc.subject.othertherapy
dc.subject.wosVirology
dc.titlePolymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalBAKKOUR, Sonia:Blood Syst Res Inst, San Francisco, CA USA
hcfmusp.author.externalMONTALVO, Leilani:Blood Syst Res Inst, San Francisco, CA USA
hcfmusp.author.externalSMID, Jerusa:Inst Infect Dis Emilio Ribas IIER, Sao Paulo, Brazil
hcfmusp.author.externalOLIVEIRA, Augusto Cesar Penalva de:Inst Infect Dis Emilio Ribas IIER, Sao Paulo, Brazil
hcfmusp.author.externalNORRIS, Philip J.:Blood Syst Res Inst, San Francisco, CA USA; Univ Calif San Francisco, San Francisco, CA 94143 USA
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcTATIANE ASSONE CASSEB
hcfmusp.contributor.author-fmusphcFERNANDA DE MELLO MALTA
hcfmusp.contributor.author-fmusphcARTHUR MAIA PAIVA
hcfmusp.contributor.author-fmusphcFERNANDA DE TOLEDO GONCALVES
hcfmusp.contributor.author-fmusphcOLINDA DO CARMO LUIZ
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO MARCONDES FONSECA
hcfmusp.contributor.author-fmusphcJORGE SIMAO DO ROSARIO CASSEB
hcfmusp.description.beginpage71
hcfmusp.description.endpage74
hcfmusp.description.issueSpecial Issue
hcfmusp.description.volume244
hcfmusp.origemWOS
hcfmusp.origem.pubmed29129607
hcfmusp.origem.scopus2-s2.0-85033383931
hcfmusp.origem.wosWOS:000425575400009
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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