Pulmonary interstitial emphysema in fatal asthma: case report and histopathological review

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMAUAD, Thais
dc.contributor.authorNASCIMENTO, Felipe B. P. do
dc.contributor.authorDOLHNIKOFF, Marisa
dc.contributor.authorPICKA, Milena C. M.
dc.contributor.authorSALDIVA, Paulo H. N.
dc.contributor.groupauthorBIAS
dc.date.accessioned2018-05-08T14:36:21Z
dc.date.available2018-05-08T14:36:21Z
dc.date.issued2018
dc.description.abstractBackground: Mortality related to asthma has decreased worldwide since the introduction of inhaled corticosteroid therapy in the past decades. However, there are still some asthma fatalities identified mainly in populations with less access to regular treatment. Pulmonary interstitial emphysema due to alveolar rupture has been rarely described as a complication of an acute severe asthma attack, and its identification in pathological analysis can be difficult. Previous studies reported the association of pulmonary interstitial emphysema and bronchial ductal gland ectasia in asthma. Case presentation: We present the case of a 42-year-old man that died due to a fatal asthma attack. Postmortem computed tomography revealed the unusual finding of acute Pulmonary Interstitial Emphysema, confirmed by pathological analysis. We reviewed 28 cases of fatal asthma tissue and identified the presence of pulmonary interstitial emphysema in 10% of the cases. Conclusions: Postmortem computed tomography is a useful complimentary diagnostic tool for autopsies. Pulmonary Interstitial Emphysema in acute exacerbations of asthma seems to be more frequent than reported. Alveolar hyperdistension and bronchial duct gland ectasia causing tissue rupture are possible mechanisms involved in the formation of Pulmonary Interstitial Emphysema. The clinical impact of Pulmonary Interstitial Emphysema in asthma is unknown.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipNational Council for Scientific and Technological Development (CNPq)
dc.identifier.citationBMC PULMONARY MEDICINE, v.18, article ID 50, 5p, 2018
dc.identifier.doi10.1186/s12890-018-0615-7
dc.identifier.issn1471-2466
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/26433
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofBMC Pulmonary Medicine
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectFatal asthma
dc.subjectAutopsy
dc.subjectPost-mortem computerized tomography
dc.subjectPulmonary interstitial emphysema
dc.subject.otherbronchial-asthma
dc.subject.otherpathology
dc.subject.otherautopsy
dc.subject.othercomplication
dc.subject.wosRespiratory System
dc.titlePulmonary interstitial emphysema in fatal asthma: case report and histopathological review
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcTHAIS MAUAD
hcfmusp.contributor.author-fmusphcFELIPE BARJUD PEREIRA DO NASCIMENTO
hcfmusp.contributor.author-fmusphcMARISA DOLHNIKOFF
hcfmusp.contributor.author-fmusphcMILENA CELY MODOLO PICKA SANTOS
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.description.articlenumber50
hcfmusp.description.volume18
hcfmusp.origemWOS
hcfmusp.origem.pubmed29554886
hcfmusp.origem.scopus2-s2.0-85044211265
hcfmusp.origem.wosWOS:000427947200002
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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