Biomarkers of human papillomavirus (HPV)-driven head and neck cancer in Latin America and Europe study: Study design and HPV DNA/p16(INK4a) status

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSICHERO, Laura
dc.contributor.authorTAGLIABUE, Marta
dc.contributor.authorMOTA, Giana
dc.contributor.authorFERREIRA, Silvaneide
dc.contributor.authorNUNES, Rafaella A. L.
dc.contributor.authorCASTANEDA, Carlos Arturo
dc.contributor.authorCASTILLO, Miluska
dc.contributor.authorCORREA, Rita Mariel
dc.contributor.authorPERDOMO, Sandra
dc.contributor.authorRODRIGUEZ-URREGO, Paula A.
dc.contributor.authorMATOS, Leandro Luongo
dc.contributor.authorMOHSSEN, Ansarin
dc.contributor.authorGHEIT, Tarik
dc.contributor.authorTOMMASINO, Massimo
dc.contributor.authorCHIOCCA, Susanna
dc.contributor.authorVILLA, Luisa Lina
dc.contributor.groupauthorHEADLAcE Study Grp
dc.date.accessioned2022-02-24T17:15:07Z
dc.date.available2022-02-24T17:15:07Z
dc.date.issued2022
dc.description.abstractBackground Human papillomavirus (HPV)-driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16(INK4a) in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. Methods HPV was genotyped by PCR-hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16(INK4a) immunohistochemistry. Results HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV-16 was the most detected. Other HPVs were found in LC. Higher rates of p16(INK4a) positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Conclusions Our results support a role for HPV-16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2017/04020-7]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [306326/2015-9, 303431/2018-0]
dc.description.sponsorshipMerck Sharp and Dohme (Investigator Initiated Studies IISP) [56004]
dc.description.sponsorshipFondo Nacional de Desarollo Cientifico, Tecnologico y de Innovacion Tecnologica (Fondecyt) [096-2017-FONDECYT]
dc.description.sponsorshipItalian Ministry of HealthMinistry of Health, Italy
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII) through AESI 2017 [AC17CIII/00003]
dc.description.sponsorshipEU-LAC Health framework
dc.identifier.citationHEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.44, n.1, p.122-133, 2022
dc.identifier.doi10.1002/hed.26912
dc.identifier.eissn1097-0347
dc.identifier.issn1043-3074
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44419
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofHead and Neck-Journal for the Sciences and Specialties of the Head and Neck
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjecthead and neck cancereng
dc.subjecthuman papillomaviruseng
dc.subjectmultinational studyeng
dc.subjectprevalenceeng
dc.subjectrisk factorseng
dc.subject.othersquamous-cell carcinomaeng
dc.subject.otheroral human-papillomaviruseng
dc.subject.otherrisk human-papillomaviruseng
dc.subject.otherprevalenceeng
dc.subject.othersurvivaleng
dc.subject.otherinfectioneng
dc.subject.otherworldwideeng
dc.subject.othertrendseng
dc.subject.otherregioneng
dc.subject.wosOtorhinolaryngologyeng
dc.subject.wosSurgeryeng
dc.titleBiomarkers of human papillomavirus (HPV)-driven head and neck cancer in Latin America and Europe study: Study design and HPV DNA/p16(INK4a) statuseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryArgentina
hcfmusp.affiliation.countryPeru
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryColômbia
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisope
hcfmusp.affiliation.countryisoar
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisoco
hcfmusp.author.externalTAGLIABUE, Marta:IRCCS, European Inst Oncol, Div Otolaryngol Head & Neck Surg, Milan, Italy
hcfmusp.author.externalCASTANEDA, Carlos Arturo:Inst Nacl Enfermedades Neoplasicas, Dept Med Oncol, Lima, Peru
hcfmusp.author.externalCASTILLO, Miluska:Inst Nacl Enfermedades Neoplasicas, Dept Res, Lima, Peru
hcfmusp.author.externalCORREA, Rita Mariel:ANLIS Dr Malbran, Inst Nacl Enfermedades Infecc, Serv Virus Oncogen, Buenos Aires, DF, Argentina
hcfmusp.author.externalPERDOMO, Sandra:Univ Hosp Fdn Santa Fe Bogot, Bogota, Colombia; Int Agcy Res Canc IARC, Genom Epidemiol Branch, Lyon, France
hcfmusp.author.externalRODRIGUEZ-URREGO, Paula A.:Univ Hosp Fdn Santa Fe Bogot, Bogota, Colombia
hcfmusp.author.externalMOHSSEN, Ansarin:IRCCS, European Inst Oncol, Div Otolaryngol Head & Neck Surg, Milan, Italy
hcfmusp.author.externalGHEIT, Tarik:Int Agcy Res Canc IARC, Infect & Canc Biol Grp, Lyon, France
hcfmusp.author.externalTOMMASINO, Massimo:Int Agcy Res Canc IARC, Infect & Canc Biol Grp, Lyon, France
hcfmusp.author.externalCHIOCCA, Susanna:IRCCS, European Inst Oncol, Dept Expt Oncol, Milan, Italy
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcLAURA CRISTINA SICHERO VETTORAZZO
hcfmusp.contributor.author-fmusphcGIANA RABELLO MOTA
hcfmusp.contributor.author-fmusphcSILVANEIDE APARECIDA FERREIRA
hcfmusp.contributor.author-fmusphcRAFAELLA ALMEIDA LIMA NUNES
hcfmusp.contributor.author-fmusphcLEANDRO LUONGO DE MATOS
hcfmusp.contributor.author-fmusphcLUISA LINA VILLA
hcfmusp.description.beginpage122
hcfmusp.description.endpage133
hcfmusp.description.issue1
hcfmusp.description.volume44
hcfmusp.origemWOS
hcfmusp.origem.pubmed34726297
hcfmusp.origem.scopus2-s2.0-85122839302
hcfmusp.origem.wosWOS:000713626300001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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