TUBERCULOSIS AMONG HIV-1-INFECTED SUBJECTS IN A TERTIARY OUT-PATIENT SERVICE IN SAO PAULO CITY, BRAZIL

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCASSEB, Jorge
dc.contributor.authorFONSECA, Luiz Augusto M.
dc.contributor.authorMEDEIROS, Lucas A.
dc.contributor.authorGONSALEZ, Claudio R.
dc.contributor.authorLAGONEGRO, Eduardo R.
dc.contributor.authorVEIGA, Ana Paula Rocha
dc.contributor.authorSILVA, Daniela C. Da
dc.contributor.authorMENDONCA, Marcelo
dc.contributor.authorDUARTE, Alberto J. S.
dc.date.accessioned2013-07-30T15:14:53Z
dc.date.available2013-07-30T15:14:53Z
dc.date.issued2012
dc.description.abstractTB is currently considered to be the most important infectious disease among HIV-1-infected subjects in developing countries, such as Brazil. A retrospective analysis of TB cases was performed, occurring from January 1995 to December 2010 in our cohort of 599 HIV positive patients. The primary outcome was the occurrence of active TB. Forty-one TB cases were diagnosed over this period of 16 years, among 599 HIV positive patients in an open cohort setting in the city of Sao Paulo, Brazil. All-time lowest mean CD4 T cell count at the time of TB diagnosis was 146 and 186 cells/mm(3), respectively. The mean HIV viral load was 5.19 log(10) copies/mL, and 59% of the patients were on HAART. TB incidence was 1.47 per 100 person-years, for a total follow-up time of 2775 person-years. The probability of surviving up to 10 years after diagnosis was 75% for TB patients as opposed to 96% for patients with other, non-TB opportunistic diseases (p = 0.03). TB can be considered a public health problem among people living with HIV in Brazil despite of the widespread use of antiretrovirals for the treatment of HIV infection/AIDS.
dc.description.abstractAtualmente, a tuberculose (TB) é considerada a doença infecciosa mais importante entre os pacientes infectados pelo HIV-1 nos países em desenvolvimento, como o Brasil. Análise retrospectiva dos casos de tuberculose ocorridos a partir de janeiro 1995 até dezembro de 2010 foi realizada em nossa coorte de 599 pacientes HIV positivos. O desfecho primário foi a ocorrência de TB ativa, e 41 casos da doença foram diagnosticados durante este período de 16 anos. As contagens médias do nadir de células T CD4 e ao momento do diagnóstico de TB foram de 146 e 217 células/mm3, respectivamente. A carga viral média de HIV foi de 5,19 log10 cópias/mL, e 59% dos pacientes estavam em tratamento com ART. A incidência de TB foi de 1,47 casos por 100 pessoas-ano, para um tempo total de seguimento da coorte de 2775 pessoas-ano. A probabilidade de sobreviver até 10 anos após o diagnóstico foi de 75% para pacientes com TB, em oposição a 96% para pacientes com outras doenças oportunistas não-TB (p = 0,03). A tuberculose pode ser considerada problema de saúde pública entre as pessoas que vivem com HIV no Brasil, apesar da ampla utilização de anti-retrovirais para o tratamento da infecção pelo HIV / AIDS
dc.description.indexMEDLINE
dc.identifier.citationREVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.54, n.5, p.257-259, 2012
dc.identifier.doi10.1590/S0036-46652012000500004
dc.identifier.issn0036-4665
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/938
dc.language.isoeng
dc.publisherINST MEDICINA TROPICAL SAO PAULO
dc.relation.ispartofRevista do Instituto de Medicina Tropical de Sao Paulo
dc.rightsopenAccess
dc.rights.holderCopyright INST MEDICINA TROPICAL SAO PAULO
dc.subjectAIDS
dc.subjectBrazil
dc.subjectCo-infection
dc.subjectIncidence
dc.subjectTB
dc.subject.otherrio-de-janeiro
dc.subject.otherantiretroviral treatment
dc.subject.otherhiv
dc.subject.othertherapy
dc.subject.othermortality
dc.subject.otherera
dc.subject.wosTropical Medicine
dc.titleTUBERCULOSIS AMONG HIV-1-INFECTED SUBJECTS IN A TERTIARY OUT-PATIENT SERVICE IN SAO PAULO CITY, BRAZIL
dc.title.alternativeTuberculose entre pacientes infectados pelo HIV-1 em ambulatório terciário de São Paulo, Brasil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalMEDEIROS, Lucas A.:Univ Sao Paulo, Med School, Secondary Immunodeficiencies Outpatient Clin, Dept Dermatol, BR-05403000 Sao Paulo, Brazil
hcfmusp.author.externalLAGONEGRO, Eduardo R.:Univ Sao Paulo, Med School, Secondary Immunodeficiencies Outpatient Clin, Dept Dermatol, BR-05403000 Sao Paulo, Brazil
hcfmusp.author.externalMENDONCA, Marcelo:Univ Sao Paulo, Med School, Secondary Immunodeficiencies Outpatient Clin, Dept Dermatol, BR-05403000 Sao Paulo, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcJORGE SIMAO DO ROSARIO CASSEB
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO MARCONDES FONSECA
hcfmusp.contributor.author-fmusphcCLAUDIO ROBERTO GONSALEZ
hcfmusp.contributor.author-fmusphcANA PAULA ROCHA VEIGA
hcfmusp.contributor.author-fmusphcDANIELA CARDEAL DA SILVA
hcfmusp.contributor.author-fmusphcALBERTO JOSE DA SILVA DUARTE
hcfmusp.description.beginpage257
hcfmusp.description.endpage259
hcfmusp.description.issue5
hcfmusp.description.volume54
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22983288
hcfmusp.origem.scieloSCIELO:S0036-46652012000500004
hcfmusp.origem.scopus2-s2.0-84866540071
hcfmusp.origem.wosWOS:000308756300004
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
hcfmusp.relation.referenceBrasil. Ministerio da Saude, MIN SAUD B TUB BRAS
hcfmusp.relation.referenceBrasil. Ministerio da Saude, 2010, MAN REC CONTR TUB BR
hcfmusp.relation.referenceCasseb J, 2003, AIDS PATIENT CARE ST, V17, P447, DOI 10.1089/108729103322395474
hcfmusp.relation.referenceCorbett EL, 2006, LANCET, V367, P926, DOI 10.1016/S0140-6736(06)68383-9
hcfmusp.relation.referenceGolub JE, 2007, AIDS, V21, P1441, DOI 10.1097/QAD.0b013e328216f441
hcfmusp.relation.referenceGranich R, 2010, CLIN INFECT DIS, V50, pS215, DOI 10.1086/651494
hcfmusp.relation.referenceGutierrez EB, 2009, HIV MED, V10, P564, DOI 10.1111/j.1468-1293.2009.00730.x
hcfmusp.relation.referencePacheco AG, 2011, AIDS RES HUM RETROV, V27, P25, DOI 10.1089/aid.2010.0089
hcfmusp.relation.referencePettit AC, 2009, INT J TUBERC LUNG D, V13, P355
hcfmusp.relation.referenceSantoro-Lopes G, 2002, CLIN INFECT DIS, V34, P543, DOI 10.1086/338641
hcfmusp.relation.referenceSaraceni V, 2008, INT J TUBERC LUNG D, V12, P769
hcfmusp.relation.referenceWhalen C, 1997, AIDS, V11, P455, DOI 10.1097/00002030-199704000-00008
hcfmusp.relation.referenceWorld Health Organization, GLOB TUB CONTR SHORT
hcfmusp.scopus.lastupdate2024-05-17
relation.isAuthorOfPublicationdb8fd0fe-568d-426b-b59b-955d4d21c0a9
relation.isAuthorOfPublicatione3cb5925-7539-4ac9-aae8-04df78bc1048
relation.isAuthorOfPublicationbde1a986-d4ec-4ba3-8c92-90eb13052032
relation.isAuthorOfPublication1d1c90c0-77bc-42dc-a8c2-b2ee3d8ce689
relation.isAuthorOfPublicationa45848f2-3f86-444a-b597-987291016201
relation.isAuthorOfPublication8e4f2c15-06a5-444b-826d-84576403144e
relation.isAuthorOfPublication.latestForDiscoverybde1a986-d4ec-4ba3-8c92-90eb13052032
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
art_CASSEB_TUBERCULOSIS_AMONG_HIV_1_INFECTED_SUBJECTS_IN_A_2012.PDF
Tamanho:
539.79 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/03
Artigos e Materiais de Revistas Científicas - LIM/38
Artigos e Materiais de Revistas Científicas - LIM/56