Impaired Post Exercise Heart Rate Recovery in Anabolic Steroid Users

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTOS, M. R. dos
dc.contributor.authorDIAS, R. G.
dc.contributor.authorLATERZA, M. C.
dc.contributor.authorRONDON, M. U. P. B.
dc.contributor.authorBRAGA, A. M. F. W.
dc.contributor.authorMOREAU, R. L. de Moraes
dc.contributor.authorNEGRAO, C. E.
dc.contributor.authorALVES, M. -J. N. N.
dc.date.accessioned2014-01-28T22:29:56Z
dc.date.available2014-01-28T22:29:56Z
dc.date.issued2013
dc.description.abstractPrevious study showed that muscle sympathetic nerve activity (MSNA) was augmented in anabolic steroids users (AASU). In the present study, we tested the hypothesis that the heart rate (HR) responses after maximal exercise testing would be reduced in AASU. 10 male AASU and 10 AAS nonusers (AASNU) were studied. Cardiopulmonary exercise was performed to assess the functional capacity and heart rate recovery. MSNA was recorded directly from the peroneal nerve by microneurography technique. Peak oxygen consumption (VO2) was lower in AASU compared to AASNU (43.66 +/- 2.24 vs. 52.70 +/- 1.68 ml/kg/min, P=0.005). HR recovery (HRR) at first and second minute was lower in AASU than AASNU (21 +/- 2 vs. 27 +/- 2 bpm, P=0.02 and 37 +/- 4 vs. 45 +/- 2 bpm, P=0.05, respectively). MSNA was higher in AASU than AASNU (29 +/- 3 vs. 20 +/- 1 bursts/min, P=0.01). Further analysis showed a correlation between HRR and MSNA (r=- 0.64, P=0.02), HRR at first minute and peak VO2 (r=0.70, P=0.01) and HRR at second minute and peak VO2 (r=0.62, P=0.02). The exacerbated sympathetic outflow associated with a lower parasympathetic activation after maximal exercise, which impairs heart rate recovery, strengthens the idea of autonomic imbalance in AASU.
dc.description.indexMEDLINE
dc.identifier.citationINTERNATIONAL JOURNAL OF SPORTS MEDICINE, v.34, n.10, p.931-935, 2013
dc.identifier.doi10.1055/s-0032-1331741
dc.identifier.issn0172-4622
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4373
dc.language.isoeng
dc.publisherGEORG THIEME VERLAG KG
dc.relation.ispartofInternational Journal of Sports Medicine
dc.rightsrestrictedAccess
dc.rights.holderCopyright GEORG THIEME VERLAG KG
dc.subjectheart rate recovery
dc.subjectfunctional capacity
dc.subjectanabolic steroids abuse
dc.subject.othercoronary-artery-disease
dc.subject.otherandrogenic steroids
dc.subject.otheranaerobic threshold
dc.subject.othertreadmill exercise
dc.subject.othermortality
dc.subject.otherevents
dc.subject.othercells
dc.subject.wosSport Sciences
dc.titleImpaired Post Exercise Heart Rate Recovery in Anabolic Steroid Users
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalDIAS, R. G.:Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05403000 Sao Paulo, Brazil
hcfmusp.author.externalRONDON, M. U. P. B.:Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05403000 Sao Paulo, Brazil
hcfmusp.author.externalMOREAU, R. L. de Moraes:Univ Sao Paulo, Coll Pharmaceut Sci, BR-05403000 Sao Paulo, Brazil
hcfmusp.citation.scopus14
hcfmusp.contributor.author-fmusphcMARCELO RODRIGUES DOS SANTOS
hcfmusp.contributor.author-fmusphcMATEUS CAMAROTI LATERZA
hcfmusp.contributor.author-fmusphcANA MARIA FONSECA WANDERLEY BRAGA
hcfmusp.contributor.author-fmusphcCARLOS EDUARDO NEGRAO
hcfmusp.contributor.author-fmusphcMARIA JANIEIRE DE NAZARE NUNES ALVES
hcfmusp.description.beginpage931
hcfmusp.description.endpage935
hcfmusp.description.issue10
hcfmusp.description.volume34
hcfmusp.origemWOS
hcfmusp.origem.pubmed23606338
hcfmusp.origem.scopus2-s2.0-84885020793
hcfmusp.origem.wosWOS:000325138900013
hcfmusp.publisher.citySTUTTGART
hcfmusp.publisher.countryGERMANY
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