Statin restores cardiac autonomic response to acute hypoxia in hypercholesterolaemia

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBRASILEIRO-SANTOS, Maria S.
dc.contributor.authorBARRETO-FILHO, Jose A. S.
dc.contributor.authorSANTOS, Raul D.
dc.contributor.authorCHACRA, Ana P. M.
dc.contributor.authorSANGALETI, Carine Teles
dc.contributor.authorALVEZ, Gisele
dc.contributor.authorBEZERRA, Otavio Coelho
dc.contributor.authorBORTOLOTO, Luiz Aparecido
dc.contributor.authorIRIGOYEN, Maria C.
dc.contributor.authorCONSOLIM-COLOMBO, Fernanda M.
dc.date.accessioned2014-04-25T21:50:39Z
dc.date.available2014-04-25T21:50:39Z
dc.date.issued2013
dc.description.abstractBackgroundHypercholesterolaemia may alter cardiovascular autonomic function. We investigated the autonomic cardiovascular regulation during normoxia and hypoxia in familial isolated HC patients with or without statin treatment. Materials and methodsLow (LF-RR) and high (HF-RR) components of spectral analysis of RR interval and systolic arterial pressure (LF-SAP) were obtained during 5min of normoxia and isocapnic hypoxia (10% O-2) in 10 normotensive familial HC patients without medication, in seven HC patients after a 12-week treatment period with 40mg of simvastatin (HC+SVT) and in eight matched normal volunteers (CO). ResultsThe HC patients had significant impairment of cardiac autonomic modulation parameters compared with CO at normoxia, which was maintained or even accentuated during hypoxia; these parameters included lower total variance of RR, increased normalized LF-RR, decreased normalized HF-RR, increased LF-RR/HF-RR ratio, higher LF-SAP component and reduced index. However, the HC+SVT group had a significant improvement in all parameters: the LF-RR and LF-SAP decreased (indicating a decrease in cardiac and vascular sympathetic activity), the HF-RR increased (indicating an increase in parasympathetic activity) and the spontaneous baroreflex sensitivity improved. These changes were detected at normoxia and were maintained during hypoxia. ConclusionsOur data are the first to show that isolated HC is characterized by an increase in cardiac and vasomotor sympathetic drive, a decrease in cardiac vagal modulation and baroreflex impairment during normoxia and hypoxia. In addition, our data suggest that statin treatment has a potential role in restoring the physiological cardiovascular autonomic control at baseline and during cardiovascular challenge.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP
dc.description.sponsorshipFundacao Zerbini
dc.description.sponsorshipCNPq, Brazil
dc.identifier.citationEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, v.43, n.12, p.1291-1298, 2013
dc.identifier.doi10.1111/eci.12177
dc.identifier.eissn1365-2362
dc.identifier.issn0014-2972
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5107
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofEuropean Journal of Clinical Investigation
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectAutonomic nervous system
dc.subjectblood pressure
dc.subjecthypercholesterolaemia
dc.subjecthypoxia
dc.subjectsimvastatin
dc.subject.otherheart-rate-variability
dc.subject.otherfamilial hypercholesterolemia
dc.subject.othersympathetic activation
dc.subject.otheratorvastatin
dc.subject.otheratherosclerosis
dc.subject.othermetaanalysis
dc.subject.otherdysfunction
dc.subject.otherdiagnosis
dc.subject.otherpressure
dc.subject.otherdisease
dc.subject.wosMedicine, General & Internal
dc.subject.wosMedicine, Research & Experimental
dc.titleStatin restores cardiac autonomic response to acute hypoxia in hypercholesterolaemia
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBRASILEIRO-SANTOS, Maria S.:Univ Sao Paulo, Inst Coracao InCor, Sao Paulo, Brazil; Univ Fed Sao Paulo UNIFESP, Sao Paulo, Brazil; Univ Fed Paraiba, BR-58059900 Joao Pessoa, Paraiba, Brazil
hcfmusp.author.externalBARRETO-FILHO, Jose A. S.:Univ Sao Paulo, Inst Coracao InCor, Sao Paulo, Brazil; Univ Fed Sergipe, Aracaju, Brazil
hcfmusp.author.externalSANGALETI, Carine Teles:Univ Sao Paulo, Inst Coracao InCor, Sao Paulo, Brazil; Univ Estadual Cent Oeste Parana, Guarapuava, Brazil
hcfmusp.author.externalALVEZ, Gisele:Univ Sao Paulo, Inst Coracao InCor, Sao Paulo, Brazil; Univ Fed Sao Paulo UNIFESP, Sao Paulo, Brazil
hcfmusp.author.externalBEZERRA, Otavio Coelho:Univ Nove Julho UNINOVE, Sao Paulo, Brazil
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcRAUL DIAS DOS SANTOS FILHO
hcfmusp.contributor.author-fmusphcANA PAULA MARTE CHACRA
hcfmusp.contributor.author-fmusphcLUIZ APARECIDO BORTOLOTTO
hcfmusp.contributor.author-fmusphcMARIA CLAUDIA COSTA IRIGOYEN
hcfmusp.contributor.author-fmusphcFERNANDA MARCIANO CONSOLIM COLOMBO
hcfmusp.description.beginpage1291
hcfmusp.description.endpage1298
hcfmusp.description.issue12
hcfmusp.description.volume43
hcfmusp.origemWOS
hcfmusp.origem.pubmed24102438
hcfmusp.origem.scopus2-s2.0-84888044421
hcfmusp.origem.wosWOS:000330101900008
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipCNPq
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipFund Zerbini
hcfmusp.scopus.lastupdate2024-05-10
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