Registry of the International Society of Uterus Transplantation: First Report

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBRANNSTROM, Mats
dc.contributor.authorTULLIUS, Stefan G.
dc.contributor.authorBRUCKER, Sara
dc.contributor.authorDAHM-KAHLER, Pernilla
dc.contributor.authorFLYCKT, Rebecca
dc.contributor.authorKISU, Iori
dc.contributor.authorANDRAUS, Wellington
dc.contributor.authorWEI, Li
dc.contributor.authorCARMONA, Francisco
dc.contributor.authorAYOUBI, Jean-Marc
dc.contributor.authorSCOLLO, Paolo
dc.contributor.authorWEYERS, Steven
dc.contributor.authorFRONEK, Jiri
dc.date.accessioned2023-02-23T15:06:32Z
dc.date.available2023-02-23T15:06:32Z
dc.date.issued2023
dc.description.abstractBackground.Uterus transplantation (UTx) is a novel type of transplantation to treat infertility in women with an absent or nonfunctioning uterus. The International Society of Uterus Transplantation (ISUTx) has developed a registry to monitor worldwide UTx activities while serving as a repository for specific research questions. Methods.The web-based registry has separate data fields for donor, recipient, surgeries, immunosuppression, rejections, pregnancies with live birth(s), and transplant hysterectomies. Data are prospectively registered. Results.A total of 45 UTx procedures have been registered; the majority (78%) of those procedures were live donor (LD) transplants. Median age of the LDs, deceased donors, and recipients were 50 y (range 32-62), 38.5 y (19-57), and 29 y (22-38), respectively. The duration of LD surgery was approximately twice as long as the recipient surgery. Postoperative complications of any Clavien-Dindo grade were registered in 20% of LDs and 24% of recipients. Rejection episodes were more frequent (33%) early after transplantation (months 1-5) compared with later time points (months 6-10; 21%). Healthy neonates were delivered by 16 recipients, with 3 women giving birth twice. The total live birth rate per embryo transfer was 35.8%. Median length of pregnancy was 35 gestational weeks. Twelve uteri were removed without childbirth, with 9 transplant hysterectomies occurring during the initial 7 mo post-UTx. Conclusions.A mandatory registry is critical to determine quality and process improvement for any novel transplantation. This registry provides a detailed analysis of 45 UTx procedures performed worldwide with a thorough analysis of outcomes and complications.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipJane and Dan Olsson Foundation
dc.description.sponsorshipSwedish Research Council
dc.description.sponsorshipKnut and Alice Walenberg Foundation
dc.identifier.citationTRANSPLANTATION, v.107, n.1, p.10-17, 2023
dc.identifier.doi10.1097/TP.0000000000004286
dc.identifier.eissn1534-6080
dc.identifier.issn0041-1337
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/51711
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINSeng
dc.relation.ispartofTransplantation
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINSeng
dc.subject.otherlive-birtheng
dc.subject.otherdonorseng
dc.subject.wosImmunologyeng
dc.subject.wosSurgeryeng
dc.subject.wosTransplantationeng
dc.titleRegistry of the International Society of Uterus Transplantation: First Reporteng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryChina
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryBélgica
hcfmusp.affiliation.countryRepública Tcheca
hcfmusp.affiliation.countrySuécia
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryJapão
hcfmusp.affiliation.countryisose
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisode
hcfmusp.affiliation.countryisojp
hcfmusp.affiliation.countryisocn
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisobe
hcfmusp.affiliation.countryisocz
hcfmusp.author.externalBRANNSTROM, Mats:Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Obstet & Gynecol, Gothenburg, Sweden
hcfmusp.author.externalTULLIUS, Stefan G.:Harvard Med Sch, Div Transplant Surg, Brigham & Womens Hosp, Boston, MA 02115 USA
hcfmusp.author.externalBRUCKER, Sara:Eberhard Karls Univ Tuebingen, Univ Hosp Tuebingen, Dept Obstet & Gynecol, Dept Womens Hlth, Tubingen, Germany
hcfmusp.author.externalDAHM-KAHLER, Pernilla:Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Obstet & Gynecol, Gothenburg, Sweden
hcfmusp.author.externalFLYCKT, Rebecca:Univ Hosp Cleveland, Med Ctr, Dept Obstet & Gynecol Reprod Endocrinol & Inferti, Cleveland, OH 44106 USA
hcfmusp.author.externalKISU, Iori:Keio Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan
hcfmusp.author.externalWEI, Li:Fourth Mil Med Univ, Xijing Hosp, Dept Obstet & Gynecol, Xian, Peoples R China
hcfmusp.author.externalCARMONA, Francisco:Univ Barcelona, Hosp Clin Barcelona, Inst Clin Gynecol Obstet & Neonatol, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain
hcfmusp.author.externalAYOUBI, Jean-Marc:Hop Foch, Dept Obstet Gynecol & Reprod Med, Suresnes, France
hcfmusp.author.externalSCOLLO, Paolo:Cannizzaro Hosp, Maternal & Child Dept, Div Obstet & Gynecol, Catania, Italy
hcfmusp.author.externalWEYERS, Steven:Univ Ghent, Dept Obstet & Gynecol, Ghent, Belgium
hcfmusp.author.externalFRONEK, Jiri:Inst Clin & Expt Med, Dept Transplantat Surg, Prague, Czech Republic
hcfmusp.citation.scopus25
hcfmusp.contributor.author-fmusphcWELLINGTON ANDRAUS
hcfmusp.description.beginpage10
hcfmusp.description.endpage17
hcfmusp.description.issue1
hcfmusp.description.volume107
hcfmusp.origemWOS
hcfmusp.origem.pubmed35951434
hcfmusp.origem.scopus2-s2.0-85141387427
hcfmusp.origem.wosWOS:000903179300005
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
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