Sex differences in gene regulatory networks during mid-gestational brain development

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTOLEDO, Victor Hugo Calegari de
dc.contributor.authorFELTRIN, Arthur Sant'Anna
dc.contributor.authorBARBOSA, Andre Rocha
dc.contributor.authorTAHIRA, Ana Carolina
dc.contributor.authorBRENTANI, Helena
dc.date.accessioned2022-10-26T14:35:48Z
dc.date.available2022-10-26T14:35:48Z
dc.date.issued2022
dc.description.abstractNeurodevetopmental disorders differ considerably between males and females, and fetal brain development is one of the most critical periods to determine risk for these disorders. Transcriptomic studies comparing male and female fetal brain have demonstrated that the highest difference in gene expression occurs in sex chromosomes, but several autossomal genes also demonstrate a slight difference that has not been yet explored. In order to investigate biological pathways underlying fetal brain sex differences, we applied medicine network principles using integrative methods such as co-expression networks (CEMiTool) and regulatory networks (netZoo). The pattern of gene expression from genes in the same pathway tend to reflect biologically relevant phenomena. In this study, network analysis of fetal brain expression reveals regulatory differences between males and females. Integrating two different bioinformatics tools, our results suggest that biological processes such as cell cycle, cell differentiation, energy metabolism and extracellular matrix organization are consistently sex-biased. MSET analysis demonstrates that these differences are relevant to neurodevelopmental disorders, including autism.eng
dc.description.indexPubMedeng
dc.identifier.citationFRONTIERS IN HUMAN NEUROSCIENCE, v.16, article ID 955607, 21p, 2022
dc.identifier.doi10.3389/fnhum.2022.955607
dc.identifier.issn1662-5161
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/49354
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Human Neuroscience
dc.rightsopenAccesseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subjectneurodevelopmental disorderseng
dc.subjectsex differenceseng
dc.subjectfetal brain developmenteng
dc.subjectgene regulatory networkseng
dc.subjectsystems biologyeng
dc.subjectautism spectrum disorder (ASD)eng
dc.subject.othertranscription factoreng
dc.subject.otherexpressioneng
dc.subject.othercancereng
dc.subject.otherdifferentiationeng
dc.subject.othercellseng
dc.subject.otherneurogenesiseng
dc.subject.otherphosphorylationeng
dc.subject.othermitochondriaeng
dc.subject.otherarchitectureeng
dc.subject.othermetabolismeng
dc.subject.wosNeuroscienceseng
dc.subject.wosPsychologyeng
dc.titleSex differences in gene regulatory networks during mid-gestational brain developmenteng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalFELTRIN, Arthur Sant'Anna:Univ Fed ABC, Ctr Matemat Comp & Cognicao, Santo Andre, Brazil
hcfmusp.author.externalBARBOSA, Andre Rocha:Lieber Inst Brain Dev, Baltimore, MD USA
hcfmusp.author.externalTAHIRA, Ana Carolina:Inst Butantan, Lab Expressao Genica, Dept Parasitol, Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcVICTOR HUGO CALEGARI DE TOLEDO
hcfmusp.contributor.author-fmusphcHELENA PAULA BRENTANI
hcfmusp.description.articlenumber955607
hcfmusp.description.volume16
hcfmusp.origemWOS
hcfmusp.origem.pubmed36061507
hcfmusp.origem.scopus2-s2.0-85137186549
hcfmusp.origem.wosWOS:000847942200001
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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