The C242T polymorphism of the p22-phox gene (CYBA) is associated with higher left ventricular mass in Brazilian hypertensive patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSCHREIBER, Roberto
dc.contributor.authorFERREIRA-SAE, Maria C.
dc.contributor.authorRONCHI, Juliana A.
dc.contributor.authorPIO-MAGALHAES, Jose A.
dc.contributor.authorCIPOLLI, Jose A.
dc.contributor.authorMATOS-SOUZA, Jose R.
dc.contributor.authorMILL, Jose G.
dc.contributor.authorVERCESI, Anibal E.
dc.contributor.authorKRIEGER, Jose E.
dc.contributor.authorFRANCHINI, Kleber G.
dc.contributor.authorPEREIRA, Alexandre C.
dc.contributor.authorNADRUZ JUNIOR, Wilson
dc.date.accessioned2017-11-27T16:24:47Z
dc.date.available2017-11-27T16:24:47Z
dc.date.issued2011
dc.description.abstractBackground: Reactive oxygen species have been implicated in the physiopathogenesis of hypertensive end-organ damage. This study investigated the impact of the C242T polymorphism of the p22-phox gene (CYBA) on left ventricular structure in Brazilian hypertensive subjects. Methods: We cross-sectionally evaluated 561 patients from 2 independent centers [Campinas (n = 441) and Vitoria (n = 120)] by clinical history, physical examination, anthropometry, analysis of metabolic and echocardiography parameters as well as p22-phox C242T polymorphism genotyping. In addition, NADPH-oxidase activity was quantified in peripheral mononuclear cells from a subgroup of Campinas sample. Results: Genotype frequencies in both samples were consistent with the Hardy-Weinberg equilibrium. Subjects with the T allele presented higher left ventricular mass/height(2.7) than those carrying the CC genotype in Campinas (76.8 +/- 1.6 vs 70.9 +/- 1.4 g/m(2.7); p = 0.009), and in Vitoria (45.6 +/- 1.9 vs 39.9 +/- 1.4 g/m(2.7); p = 0.023) samples. These results were confirmed by stepwise regression analyses adjusted for age, gender, blood pressure, metabolic variables and use of anti-hypertensive medications. In addition, increased NADPH-oxidase activity was detected in peripheral mononuclear cells from T allele carriers compared with CC genotype carriers (p = 0.03). Conclusions: The T allele of the p22-phox C242T polymorphism is associated with higher left ventricular mass/height(2.7) and increased NADPH-oxidase activity in Brazilian hypertensive patients. These data suggest that genetic variation within NADPH-oxidase components may modulate left ventricular remodeling in subjects with systemic hypertension.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [Proc. 2010/16252-0]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [Proc. 474966/2010-0, 474966/2010-0]
dc.identifier.citationBMC MEDICAL GENETICS, v.12, article ID 114, 6p, 2011
dc.identifier.doi10.1186/1471-2350-12-114
dc.identifier.issn1471-2350
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22811
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofBMC Medical Genetics
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subjectp22-phox
dc.subjectleft ventricle
dc.subjecthypertension
dc.subjectpolymorphism
dc.subjectNADPH-oxidase
dc.subject.othercoronary-artery-disease
dc.subject.otherp22 phox gene
dc.subject.othernadph oxidase
dc.subject.othernad(p)h oxidase
dc.subject.otherhypertrophy
dc.subject.otherp22phox
dc.subject.otherpopulation
dc.subject.otherp22(phox)
dc.subject.otheratherosclerosis
dc.subject.othervariant
dc.subject.wosGenetics & Heredity
dc.titleThe C242T polymorphism of the p22-phox gene (CYBA) is associated with higher left ventricular mass in Brazilian hypertensive patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSCHREIBER, Roberto:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalFERREIRA-SAE, Maria C.:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalRONCHI, Juliana A.:Univ Estadual Campinas, Dept Clin Pathol, Campinas, SP, Brazil
hcfmusp.author.externalPIO-MAGALHAES, Jose A.:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalCIPOLLI, Jose A.:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalMATOS-SOUZA, Jose R.:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalMILL, Jose G.:Univ Fed Espirito Santo, Vitoria, Brazil
hcfmusp.author.externalVERCESI, Anibal E.:Univ Estadual Campinas, Dept Clin Pathol, Campinas, SP, Brazil
hcfmusp.author.externalFRANCHINI, Kleber G.:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalNADRUZ JUNIOR, Wilson:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.citation.scopus15
hcfmusp.contributor.author-fmusphcJOSE EDUARDO KRIEGER
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.description.articlenumber114
hcfmusp.description.volume12
hcfmusp.origemWOS
hcfmusp.origem.pubmed21884584
hcfmusp.origem.scopus2-s2.0-80052175971
hcfmusp.origem.wosWOS:000295291700001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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