Impact of hormone therapy on the bone density of women with premature ovarian insufficiency: A systematic review

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOSTA, Giulia Paiva Oliveira
dc.contributor.authorFERREIRA-FILHO, Edson Santos
dc.contributor.authorSIMOES, Ricardo dos Santos
dc.contributor.authorSOARES-JUNIOR, Jose Maria
dc.contributor.authorBARACAT, Edmund Chada
dc.contributor.authorMACIEL, Gustavo Arantes Rosa
dc.date.accessioned2023-02-23T14:55:49Z
dc.date.available2023-02-23T14:55:49Z
dc.date.issued2023
dc.description.abstractIntroduction: Women with premature ovarian insufficiency (POI) are exposed to a long period of estrogenic deficiency, which potentially brings higher health risks, especially regarding bone health. We performed a systematic review of the literature to evaluate the effect of hormone therapy (HT) on bone mineral density (BMD) in women with POI.Materials and methods: A systematic search was performed of the MEDLINE and EMBASE databases up to September 2021. We included studies that analyzed women with idiopathic (spontaneous) POI treated with HT, and those who had BMD evaluated. Analysis of risk of bias of studies selected was performed.Results: We found 335 articles and selected 16 studies according to the inclusion criteria. Most of the studies revealed lower bone density in both the femoral neck and lumbar spine of women with POI compared with healthy women. Bone mass had the tendency to remain stable in women treated with estrogen + progestin therapy. However, in women already with bone mass loss, the therapy -in the doses most frequently used -was not able to revert the loss. Higher doses of estrogen seem to have a positive impact on BMD, as did combined oral contraceptives used continuously. Also, the interruption of HT for longer than one year was linked to significant bone loss.Conclusion: Although HT brings clear benefits, further studies are needed to establish its long-term effects, as well as doses and formulations with better protective effects on the bone mass of these women.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationMATURITAS, v.167, p.105-112, 2023
dc.identifier.doi10.1016/j.maturitas.2022.09.011
dc.identifier.eissn1873-4111
dc.identifier.issn0378-5122
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/51557
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTDeng
dc.relation.ispartofMaturitas
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER IRELAND LTDeng
dc.subjectPrimary ovarian insufficiencyeng
dc.subjectBone densityeng
dc.subjectEstrogen replacement therapyeng
dc.subject.otherrandomized controlled-trialeng
dc.subject.othermass acquisitioneng
dc.subject.othermineral densityeng
dc.subject.otheryoung-womeneng
dc.subject.otherfailureeng
dc.subject.othermetaanalyseseng
dc.subject.otherreplacementeng
dc.subject.othermanagementeng
dc.subject.otherdiseaseeng
dc.subject.otherriskeng
dc.subject.wosGeriatrics & Gerontologyeng
dc.subject.wosObstetrics & Gynecologyeng
dc.titleImpact of hormone therapy on the bone density of women with premature ovarian insufficiency: A systematic revieweng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcGIULIA PAIVA OLIVEIRA COSTA
hcfmusp.contributor.author-fmusphcEDSON SANTOS FERREIRA FILHO
hcfmusp.contributor.author-fmusphcRICARDO DOS SANTOS SIMOES
hcfmusp.contributor.author-fmusphcJOSE MARIA SOARES JUNIOR
hcfmusp.contributor.author-fmusphcEDMUND CHADA BARACAT
hcfmusp.contributor.author-fmusphcGUSTAVO ARANTES ROSA MACIEL
hcfmusp.description.beginpage105
hcfmusp.description.endpage112
hcfmusp.description.volume167
hcfmusp.origemWOS
hcfmusp.origem.pubmed36368093
hcfmusp.origem.scopus2-s2.0-85142940308
hcfmusp.origem.wosWOS:000896018300001
hcfmusp.publisher.cityCLAREeng
hcfmusp.publisher.countryIRELANDeng
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