The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTREVISAN, Alexandre Maximiliano
dc.contributor.authorCOGLIATI, Bruno
dc.contributor.authorHOMEM, Adriana Ribeiro
dc.contributor.authorALOIAV, Thiago Pinheiro Arrais
dc.contributor.authorAQUINO NETO, Nelson de
dc.contributor.authorMOREIRA, Jairo Marques
dc.contributor.authorRENO, Leonardo da Cruz
dc.contributor.authorNAUMANN, Alexandre Moulin
dc.contributor.authorGALVAO, Flavio Henrique Ferreira
dc.contributor.authorANDRAUS, Wellington
dc.contributor.authorD'ALBUQUERQUE, Luiz Augusto Carneiro
dc.date.accessioned2020-03-24T14:48:26Z
dc.date.available2020-03-24T14:48:26Z
dc.date.issued2019
dc.description.abstractPurpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST, ALT, GGT) and histology. Results: The mice with Cx43 deficiency showed an ALT mean value of 4166 vs. 307 in the control group (p<0.001); AST mean value of 7231 vs. 471 in the control group (p<0.001); GGT mean value of 9.4 vs. 1.7 in the control group (p=0.001); histology showed necrosis and inflammation in the knockout group. Conclusions: This research demonstrated that the deficiency of Cx43 worses the prognosis for liver injury. The topic is a promising target for therapeutics advancements in liver diseases and procedures.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCAPESCAPES
dc.identifier.citationACTA CIRURGICA BRASILEIRA, v.34, n.10, article ID e201901003, 9p, 2019
dc.identifier.doi10.1590/s0102-865020190100000003
dc.identifier.eissn1678-2674
dc.identifier.issn0102-8650
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35457
dc.language.isoeng
dc.publisherACTA CIRURGICA BRASILEIRAeng
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsopenAccesseng
dc.rights.holderCopyright ACTA CIRURGICA BRASILEIRAeng
dc.subjectGAP junctionseng
dc.subjectConnexin 43eng
dc.subjectIschemiaeng
dc.subjectReperfusioneng
dc.subjectLivereng
dc.subjectCell communicationeng
dc.subjectMiceeng
dc.subject.otheroxidative stresseng
dc.subject.otherresectioneng
dc.subject.wosSurgeryeng
dc.titleThe liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43eng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalTREVISAN, Alexandre Maximiliano:Univ Sao Paulo, Postgrad Program Med Sci Gastroenterol, Dept Gastroenterol, Sch Med,Med Invest Lab LIM 37, Sao Paulo, Brazil
hcfmusp.author.externalCOGLIATI, Bruno:Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo, SP, Brazil
hcfmusp.author.externalHOMEM, Adriana Ribeiro:Univ Sao Paulo, Med Invest Lab LIM 37, Sch Med, Dept Gastroenterol, Sao Paulo, SP, Brazil
hcfmusp.author.externalALOIAV, Thiago Pinheiro Arrais:Hosp Albert Einstein, Sao Paulo, SP, Brazil
hcfmusp.author.externalAQUINO NETO, Nelson de:Univ Sao Paulo, Postgrad Program Med Surg Gastroenterol, Sch Med, Sao Paulo, SP, Brazil
hcfmusp.author.externalMOREIRA, Jairo Marques:Hosp Albert Einstein, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcALEXANDRE MAXIMILIANO TREVISAN
hcfmusp.contributor.author-fmusphcALEXANDRE MOULIN NAUMANN
hcfmusp.contributor.author-fmusphcFLAVIO HENRIQUE FERREIRA GALVAO
hcfmusp.contributor.author-fmusphcWELLINGTON ANDRAUS
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO CARNEIRO D ALBUQUERQUE
hcfmusp.description.articlenumbere201901003
hcfmusp.description.issue10
hcfmusp.description.volume34
hcfmusp.origemWOS
hcfmusp.origem.pubmed31851211
hcfmusp.origem.scieloSCIELO:S0102-86502019001000212
hcfmusp.origem.scopus2-s2.0-85076976883
hcfmusp.origem.wosWOS:000507335300001
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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