Is cardiac tissue more susceptible than lung to oxidative effects induced by chronic nasotropic instillation of residual oil fly ash (ROFA)?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDAMIANI, Roberto Marques
dc.contributor.authorPIVA, Marcella Ody
dc.contributor.authorPETRY, Marcelo Rafael
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento
dc.contributor.authorOLIVEIRA, Alexandre Tavares Duarte de
dc.contributor.authorRHODEN, Claudia Ramos
dc.date.accessioned2013-10-02T19:32:07Z
dc.date.available2013-10-02T19:32:07Z
dc.date.issued2012
dc.description.abstractThe current study aimed to determine the role of oxidants in cardiac and pulmonary toxicities induced by chronic exposure to ROFA. Eighty Wistar rats were divided into four groups: G1 (10 mu L Saline), G2 (ROFA 50 mu g/10 mu L), G3 (ROFA 250 mu g/10 mu L) and G4 (ROFA 500 mu g/10 mu L). Rats received ROFA by nasotropic instillation for 90 days. After that, they were euthanized and bronchoalveolar lavage (BAL) was performed for total count of leukocytes, protein and lactate dehydrogenase (LDH) determinations. Lungs and heart were removed to measure lipid peroxidation (MDA), catalase (CAT) and superoxide dismutase (SOD) activity. BAL presented an increase in leukocytes count in G4 in comparison to the Saline group (p = 0.019). In lung, MDA level was not modified by ROFA, while CAT was higher in G4 when compared to all other groups (p = 0.013). In heart, G4 presented an increase in MDA (p = 0.016) and CAT (p = 0.027) levels in comparison to G1. The present study demonstrated cardiopulmonary oxidative changes after a chronic ROFA exposure. More specifically, the heart tissue seems to be more susceptible to oxidative effects of long-term exposure to ROFA than the lung.
dc.description.indexMEDLINE
dc.description.sponsorshipUniversidade Federal de Ciencias da Saude de Porto Alegre, Brazil
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
dc.identifier.citationTOXICOLOGY MECHANISMS AND METHODS, v.22, n.7, p.533-539, 2012
dc.identifier.doi10.3109/15376516.2012.692109
dc.identifier.issn1537-6516
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2573
dc.language.isoeng
dc.publisherINFORMA HEALTHCARE
dc.relation.ispartofToxicology Mechanisms and Methods
dc.rightsrestrictedAccess
dc.rights.holderCopyright INFORMA HEALTHCARE
dc.subjectROFA
dc.subjectchronic exposure
dc.subjectair pollution
dc.subjectcardiopulmonary oxidative stress
dc.subject.otherparticulate air-pollution
dc.subject.otherconcentrated ambient particles
dc.subject.othercoronary-heart-disease
dc.subject.otheralveolar macrophage
dc.subject.otherinhalation exposure
dc.subject.otherlipid-peroxidation
dc.subject.otherhydrogen-peroxide
dc.subject.othersao-paulo
dc.subject.otherpulmonary
dc.subject.otherinflammation
dc.subject.wosToxicology
dc.titleIs cardiac tissue more susceptible than lung to oxidative effects induced by chronic nasotropic instillation of residual oil fly ash (ROFA)?
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalDAMIANI, Roberto Marques:Univ Fed Ciencias Saude Porto Alegre, Lab Estresse Oxidat & Poluicao Atmosferica, Porto Alegre, RS, Brazil
hcfmusp.author.externalPIVA, Marcella Ody:Univ Fed Ciencias Saude Porto Alegre, Lab Estresse Oxidat & Poluicao Atmosferica, Porto Alegre, RS, Brazil
hcfmusp.author.externalPETRY, Marcelo Rafael:Univ Fed Ciencias Saude Porto Alegre, Lab Estresse Oxidat & Poluicao Atmosferica, Porto Alegre, RS, Brazil
hcfmusp.author.externalOLIVEIRA, Alexandre Tavares Duarte de:Univ Fed Ciencias Saude Porto Alegre, Dept Ciencias Basicas Saude, Porto Alegre, RS, Brazil
hcfmusp.author.externalRHODEN, Claudia Ramos:Univ Fed Ciencias Saude Porto Alegre, Lab Estresse Oxidat & Poluicao Atmosferica, Porto Alegre, RS, Brazil
hcfmusp.citation.scopus12
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.description.beginpage533
hcfmusp.description.endpage539
hcfmusp.description.issue7
hcfmusp.description.volume22
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22563929
hcfmusp.origem.scopus2-s2.0-84865311857
hcfmusp.origem.wosWOS:000307997700006
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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hcfmusp.remissive.sponsorshipCAPES
hcfmusp.remissive.sponsorshipCNPq
hcfmusp.scopus.lastupdate2024-05-10
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