Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorWOJITANI, Maria Dulce Kaoro Horie
dc.contributor.authorAGUIAR, Lana Maria de
dc.contributor.authorBARACAT, Edmond Chada
dc.contributor.authorLINHARES, Iara Moreno
dc.date.accessioned2013-07-30T15:09:01Z
dc.date.available2013-07-30T15:09:01Z
dc.date.issued2012
dc.description.abstractObjective The influence of functional polymorphisms in the genes coding for mannose-binding lectin (MBL) and interleukin-1 receptor antagonist (IL-1ra) on recurrent vulvovaginal candidiasis (RVVC) were examined in an urban Brazilian population. Methods DNA was isolated from buccal swabs of 100 women with RVVC and 100 control women and tested by gene amplification for a single nucleotide polymorphism in codon 54 of the MBL2 gene and for a length polymorphism in intron 2 of the IL1RN gene. Genotype and allele frequencies were compared between groups. Results The frequency of the variant MBL2 B allele, associated with reduced circulating and vaginal MBL concentrations, was 27.0% in RVVC and 8.5% in control women (p < .0001). The MBL2 B, B genotype was present in 12% of RVVC patients and 1% of controls (p = .0025). The IL1RN 2 allele frequency, associated with the highest level of unopposed IL-1 beta activity, was 24.0% in RVVC and 23.4% in controls. The IL1RN genotype distribution was also similar in both groups. Conclusion Carriage of the MBL2 codon 54 polymorphism, but not the IL1RN length polymorphism, predisposes to RVVC in Brazilian women.
dc.description.indexMEDLINE
dc.identifier.citationARCHIVES OF GYNECOLOGY AND OBSTETRICS, v.285, n.1, p.149-153, 2012
dc.identifier.doi10.1007/s00404-011-1920-z
dc.identifier.issn0932-0067
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/831
dc.language.isoeng
dc.publisherSPRINGER HEIDELBERG
dc.relation.ispartofArchives of Gynecology and Obstetrics
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER HEIDELBERG
dc.subjectRecurrent vulvovaginal candidiasis
dc.subjectMannose-binding lectin
dc.subjectInterleukin-1 receptor antagonist
dc.subjectGenetic polymorphism
dc.subject.otherhost-defense
dc.subject.otherwomen
dc.subject.othersusceptibility
dc.subject.otheralbicans
dc.subject.otherhistory
dc.subject.wosObstetrics & Gynecology
dc.titleAssociation between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus27
hcfmusp.contributor.author-fmusphcMARIA DULCE CAORO HORIE WOJITANI
hcfmusp.contributor.author-fmusphcLANA MARIA DE AGUIAR
hcfmusp.contributor.author-fmusphcEDMUND CHADA BARACAT
hcfmusp.contributor.author-fmusphcIARA MORENO LINHARES
hcfmusp.description.beginpage149
hcfmusp.description.endpage153
hcfmusp.description.issue1
hcfmusp.description.volume285
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed21655939
hcfmusp.origem.scopus2-s2.0-84860821438
hcfmusp.origem.wosWOS:000299121900025
hcfmusp.publisher.cityHEIDELBERG
hcfmusp.publisher.countryGERMANY
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