Acute cholestatic hepatitis caused by amoxicillin/clavulanate

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBERALDO, Daniel Oliveira
dc.contributor.authorMELO, Joanderson Fernandes
dc.contributor.authorBONFIM, Alexandre Vidal
dc.contributor.authorTEIXEIRA, Andrei Alkmim
dc.contributor.authorTEIXEIRA, Ricardo Alkmim
dc.contributor.authorDUARTE, Andre Loyola
dc.date.accessioned2014-04-25T22:04:56Z
dc.date.available2014-04-25T22:04:56Z
dc.date.issued2013
dc.description.abstractAmoxicillin/clavulanate is a synthetic penicillin that is currently commonly used, especially for the treatment of respiratory and cutaneous infections. In general, it is a well-tolerated oral antibiotic. However, amoxicillin/clavulanate can cause adverse effects, mainly cutaneous, gastrointestinal, hepatic and hematologic, in some cases. Presented here is a case report of a 63-year-old male patient who developed cholestatic hepatitis after recent use of amoxicillin/clavulanate. After 6 wk of prolonged use of the drug, he began to show signs of cholestatic icterus and developed severe hyperbilirubinemia (total bilirubin > 300 mg/L). Diagnostic investigation was conducted by ultrasonography of the upper abdomen, serum tests for infection history, laboratory screening of autoimmune diseases, nuclear magnetic resonance (NMR) of the abdomen with bile duct-NMR and transcutaneous liver biopsy guided by ultrasound. The duration of disease was approximately 4 mo, with complete resolution of symptoms and laboratory changes at the end of that time period. Specific treatment was not instituted, only a combination of anti-emetic (metoclopramide) and cholestyramine for pruritus.
dc.description.indexMEDLINE
dc.identifier.citationWORLD JOURNAL OF GASTROENTEROLOGY, v.19, n.46, p.8789-8792, 2013
dc.identifier.doi10.3748/wjg.v19.i46.8789
dc.identifier.eissn2219-2840
dc.identifier.issn1007-9327
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5259
dc.language.isoeng
dc.publisherBAISHIDENG PUBL GRP CO LTD
dc.relation.ispartofWorld Journal of Gastroenterology
dc.rightsopenAccess
dc.rights.holderCopyright BAISHIDENG PUBL GRP CO LTD
dc.subjectHepatology
dc.subjectHepatitis
dc.subjectAmoxicillin/Clavulanate
dc.subjectDrug reactions
dc.subjectHyperbilirubinemia
dc.subject.otheramoxicillin-clavulanic acid
dc.subject.otherdrug-induced hepatitis
dc.subject.otherhepatotoxicity
dc.subject.otherassociation
dc.subject.wosGastroenterology & Hepatology
dc.titleAcute cholestatic hepatitis caused by amoxicillin/clavulanate
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBERALDO, Daniel Oliveira:Hosp Renascentista, Dept Internal Med, BR-37550000 Pouso Alegre, MG, Brazil; Univ Fed Sao Paulo, Escola Paulista Med, Dept Nephrol, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalMELO, Joanderson Fernandes:Hosp Renascentista, Dept Internal Med, BR-37550000 Pouso Alegre, MG, Brazil
hcfmusp.author.externalBONFIM, Alexandre Vidal:Hosp Renascentista, Dept Internal Med, BR-37550000 Pouso Alegre, MG, Brazil; Univ Fed Sao Paulo, Escola Paulista Med, Dept Cardiol, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalTEIXEIRA, Andrei Alkmim:Hosp Renascentista, Dept Internal Med, BR-37550000 Pouso Alegre, MG, Brazil; Univ Fed Sao Paulo, Escola Paulista Med, Dept Nephrol, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalDUARTE, Andre Loyola:Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, BR-01509010 Sao Paulo, Brazil
hcfmusp.citation.scopus11
hcfmusp.contributor.author-fmusphcRICARDO ALKMIM TEIXEIRA
hcfmusp.description.beginpage8789
hcfmusp.description.endpage8792
hcfmusp.description.issue46
hcfmusp.description.volume19
hcfmusp.origemWOS
hcfmusp.origem.pubmed24379601
hcfmusp.origem.scopus2-s2.0-84890345398
hcfmusp.origem.wosWOS:000329129200039
hcfmusp.publisher.cityWANCHAI
hcfmusp.publisher.countryPEOPLES R CHINA
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