Differential Diagnosis Findings Between Alzheimer's Disease and Major Depressive Disorder: A Review

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art_DURAES_Differential_Diagnosis_Findings_Between_Alzheimers_Disease_and_Major_2022.PDF (1.76 MB)
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
Título da Revista
ISSN da Revista
Título do Volume
Editora
AVES
Autores
Citação
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, v.32, n.1, p.80-+, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Differentiating diagnosis between Alzheimer's disease and major depressive disorder in the elderly is a great clinical challenge. This study aimed to identify the establishment of differential diagnosis protocols between Alzheimer's disease and major depressive disorder. Methods: We searched studies in the Ovid MEDLINE, EMBASE, PsycINFO, and Web of Science databases between 2009 and 2019. A total of 155 references were found for searching relevant articles using Boolean search. After exclusion of redundancies and assessing of title, abstract, and full text for eligibility, 11 articles were selected. The total sample size was 1077 distributed in 8 different countries. Results: Significant results were found for differential diagnosis between Alzheimer's disease and major depressive disorder, such as overall mental status, episodic memory, visuospatial construction, delayed recognition task, semantic verbal fluency, visual task in short-term memory, atrophy of the hippocampus, cortical activation in specific tasks, and cerebrospinal fluid biomarkers. Conclusion: These findings are good pathways for discriminating Alzheimer's disease from major depression in the elderly.
Palavras-chave
Alzheimer's disease, major depressive disorder, differential diagnosis, review
URI
https://observatorio.fm.usp.br/handle/OPI/47465
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Coleções
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21