Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorVALLEJO-VAZ, Antonio J.
dc.contributor.authorSTEVENS, Christophe A. T.
dc.contributor.authorLYONS, Alexander R. M.
dc.contributor.authorDHARMAYAT, Kanika I.
dc.contributor.authorFREIBERGER, Tomas
dc.contributor.authorHOVINGH, G. Kees
dc.contributor.authorMATA, Pedro
dc.contributor.authorRAAL, Frederick J.
dc.contributor.authorSANTOS, Raul D.
dc.contributor.authorSORAN, Handrean
dc.contributor.authorWATTS, Gerald F.
dc.contributor.authorABIFADEL, Marianne
dc.contributor.authorAGUILAR-SALINAS, Carlos A.
dc.contributor.authorALHABIB, Khalid F.
dc.contributor.authorALKHNIFSAWI, Mutaz
dc.contributor.authorALMAHMEED, Wael
dc.contributor.authorALNOURI, Fahad
dc.contributor.authorALONSO, Rodrigo
dc.contributor.authorAL-RASADI, Khalid
dc.contributor.authorAL-SARRAF, Ahmad
dc.contributor.authorAL-SAYED, Nasreen
dc.contributor.authorARAUJO, Francisco
dc.contributor.authorASHAVAID, Tester F.
dc.contributor.authorBANACH, Maciej
dc.contributor.authorBELIARD, Sophie
dc.contributor.authorBENN, Marianne
dc.contributor.authorBINDER, Christoph J.
dc.contributor.authorBOGSRUD, Martin P.
dc.contributor.authorBOURBON, Mafalda
dc.contributor.authorCHLEBUS, Krzysztof
dc.contributor.authorCORRAL, Pablo
dc.contributor.authorDAVLETOV, Kairat
dc.contributor.authorDESCAMPS, Olivier S.
dc.contributor.authorDURST, Ronen
dc.contributor.authorEZHOV, Marat
dc.contributor.authorGAITA, Dan
dc.contributor.authorGENEST, Jacques
dc.contributor.authorGROSELJ, Urh
dc.contributor.authorHARADA-SHIBA, Mariko
dc.contributor.authorHOLVEN, Kirsten B.
dc.contributor.authorKAYIKCIOGLU, Meral
dc.contributor.authorKHOVIDHUNKIT, Weerapan
dc.contributor.authorLALIC, Katarina
dc.contributor.authorLATKOVSKIS, Gustavs
dc.contributor.authorLAUFS, Ulrich
dc.contributor.authorLIBEROPOULOS, Evangelos
dc.contributor.authorLIMA-MARTINEZ, Marcos M.
dc.contributor.authorLIN, Jie
dc.contributor.authorMAHER, Vincent
dc.contributor.authorMARAIS, A. David
dc.contributor.authorMAERZ, Winfried
dc.contributor.authorMIRRAKHIMOV, Erkin
dc.contributor.authorMISEREZ, Andre R.
dc.contributor.authorMITCHENKO, Olena
dc.contributor.authorNAWAWI, Hapizah
dc.contributor.authorNORDESTGAARD, Borge G.
dc.contributor.authorPANAYIOTOU, Andrie G.
dc.contributor.authorPARAGH, Gyorgy
dc.contributor.authorPETRULIONIENE, Zaneta
dc.contributor.authorPOJSKIC, Belma
dc.contributor.authorPOSTADZHIYAN, Arman
dc.contributor.authorRASLOVA, Katarina
dc.contributor.authorREDA, Ashraf
dc.contributor.authorREINER, Zeljko
dc.contributor.authorSADIQ, Fouzia
dc.contributor.authorSADOH, Wilson Ehidiamen
dc.contributor.authorSCHUNKERT, Heribert
dc.contributor.authorSHEK, Aleksandr B.
dc.contributor.authorSTOLL, Mario
dc.contributor.authorSTROES, Erik
dc.contributor.authorSU, Ta-Chen
dc.contributor.authorSUBRAMANIAM, Tavintharan
dc.contributor.authorSUSEKOV, Andrey V.
dc.contributor.authorTILNEY, Myra
dc.contributor.authorTOMLINSON, Brian
dc.contributor.authorTRUONG, Thanh Huong
dc.contributor.authorTSELEPIS, Alexandros D.
dc.contributor.authorTYBJAERG-HANSEN, Anne
dc.contributor.authorCARDENAS, Alejandra Vazquez
dc.contributor.authorVIIGIMAA, Margus
dc.contributor.authorWANG, Luya
dc.contributor.authorYAMASHITA, Shizuya
dc.contributor.authorTOKGOZOGLU, Lale
dc.contributor.authorCATAPANO, Alberico L.
dc.contributor.authorRAY, Kausik K.
dc.contributor.groupauthorEAS Familial Hypercholesterolaemia
dc.date.accessioned2021-12-16T14:18:11Z
dc.date.available2021-12-16T14:18:11Z
dc.date.issued2021
dc.description.abstractBackground The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally. Methods Using FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Data were assessed overall and by WHO regions, sex, and index versus non-index cases. Findings Of the 61 612 individuals in the registry, 42 167 adults (21 999 [53.6%] women) from 56 countries were included in the study. Of these, 31 798 (75.4%) were diagnosed with the Dutch Lipid Clinic Network criteria, and 35 490 (84.2%) were from the WHO region of Europe. Median age of participants at entry in the registry was 46.2 years (IQR 34.3-58.0); median age at diagnosis of familial hypercholesterolaemia was 44.4 years (32.5-56.5), with 40.2% of participants younger than 40 years when diagnosed. Prevalence of cardiovascular risk factors increased progressively with age and varied by WHO region. Prevalence of coronary disease was 17.4% (2.1% for stroke and 5.2% for peripheral artery disease), increasing with concentrations of untreated LDL cholesterol, and was about two times lower in women than in men. Among patients receiving lipid-lowering medications, 16 803 (81.1%) were receiving statins and 3691 (21.2%) were on combination therapy, with greater use of more potent lipid-lowering medication in men than in women. Median LDL cholesterol was 5.43 mmol/L (IQR 4.32-6.72) among patients not taking lipid-lowering medications and 4.23 mmol/L (3.20-5.66) among those taking them. Among patients taking lipid-lowering medications, 2.7% had LDL cholesterol lower than 1.8 mmol/L; the use of combination therapy, particularly with three drugs and with proprotein convertase subtilisin-kexin type 9 inhibitors, was associated with a higher proportion and greater odds of having LDL cholesterol lower than 1.8 mmol/L. Compared with index cases, patients who were non-index cases were younger, with lower LDL cholesterol and lower prevalence of cardiovascular risk factors and cardiovascular diseases (all p<0.001). Interpretation Familial hypercholesterolaemia is diagnosed late. Guideline-recommended LDL cholesterol concentrations are infrequently achieved with single-drug therapy. Cardiovascular risk factors and presence of coronary disease were lower among non-index cases, who were diagnosed earlier. Earlier detection and greater use of combination therapies are required to reduce the global burden of familial hypercholesterolaemia.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipPfizer Independent Grant for Learning Change [16157823]
dc.description.sponsorshipAmgenAmgen
dc.description.sponsorshipMerck Sharp DohmeMerck & Company
dc.description.sponsorshipSanofi-AventisSanofi-Aventis
dc.description.sponsorshipDaiichi SankyoDaiichi Sankyo Company Limited
dc.description.sponsorshipRegeneronRegeneron
dc.description.sponsorshipNational Institute for Health Research (NIHR) Imperial Biomedical Research Centre, UK
dc.description.sponsorshipNIHRNational Institute for Health Research (NIHR)
dc.description.sponsorshipCzech Ministry of HealthMinistry of Health, Czech Republic [NU20-02-00261]
dc.description.sponsorshipCanadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR)
dc.description.sponsorshipAustrian Heart Foundation
dc.description.sponsorshipTyrolean Regional Government
dc.description.sponsorshipGulf Heart Association
dc.identifier.citationLANCET, v.398, n.10312, p.1713-1725, 2021
dc.identifier.doi10.1016/S0140-6736(21)01122-3
dc.identifier.eissn1474-547X
dc.identifier.issn0140-6736
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/43791
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INCeng
dc.relation.ispartofLancet
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCIENCE INCeng
dc.subject.otherprevalenceeng
dc.subject.otherclinicianeng
dc.subject.otherguidanceeng
dc.subject.otherinsightseng
dc.subject.wosMedicine, General & Internaleng
dc.titleGlobal perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)eng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
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hcfmusp.author.externalVALLEJO-VAZ, Antonio J.:Imperial Coll London, Sch Publ Hlth, Dept Primary Care & Publ Hlth, Imperial Ctr Cardiovasc Dis Prevent, London, England
hcfmusp.author.externalSTEVENS, Christophe A. T.:Imperial Coll London, Sch Publ Hlth, Dept Primary Care & Publ Hlth, Imperial Ctr Cardiovasc Dis Prevent, London, England
hcfmusp.author.externalLYONS, Alexander R. M.:Imperial Coll London, Sch Publ Hlth, Dept Primary Care & Publ Hlth, Imperial Ctr Cardiovasc Dis Prevent, London, England
hcfmusp.author.externalDHARMAYAT, Kanika I.:Imperial Coll London, Sch Publ Hlth, Dept Primary Care & Publ Hlth, Imperial Ctr Cardiovasc Dis Prevent, London, England
hcfmusp.author.externalFREIBERGER, Tomas:Masaryk Univ, Ctr Cardiovasc Surg & Transplantat, Brno, Czech Republic; Masaryk Univ, Med Fac, Brno, Czech Republic
hcfmusp.author.externalHOVINGH, G. Kees:Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands
hcfmusp.author.externalMATA, Pedro:Fdn Hipercolesterolemia Familiar, Madrid, Spain
hcfmusp.author.externalRAAL, Frederick J.:Univ Witwatersrand, Carbohydrate & Lipid Metab Res Unit, Fac Hlth Sci, Johannesburg, South Africa
hcfmusp.author.externalSORAN, Handrean:Manchester Univ NHS Fdn Trust, Manchester, Lancs, England
hcfmusp.author.externalWATTS, Gerald F.:Univ Western Australia, Sch Med, Fac Hlth & Med Sci, Perth, WA, Australia; Royal Perth Hosp, Dept Cardiol, Lipid Disorders Clin, Cardiometab Serv, Perth, WA, Australia
hcfmusp.author.externalABIFADEL, Marianne:St Joseph Univ, Lab Biochem & Mol Therapeut, Fac Pharm, Beirut, Lebanon
hcfmusp.author.externalAGUILAR-SALINAS, Carlos A.:Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Invest Enfermedades Metab, Mexico City, DF, Mexico; Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey, Mexico
hcfmusp.author.externalALHABIB, Khalid F.:King Saud Univ, Dept Cardiac Sci, Coll Med, King Fahad Cardiac Ctr, Riyadh, Saudi Arabia
hcfmusp.author.externalALKHNIFSAWI, Mutaz:Univ Al Qadisiyah, Fac Med, Al Diwaniyah, Iraq
hcfmusp.author.externalALMAHMEED, Wael:Cleveland Clin Abu Dhabi, Heart & Vasc Inst, Abu Dhabi, U Arab Emirates
hcfmusp.author.externalALNOURI, Fahad:Prince Sultan Cardiac Ctr, Adult Cardiol Dept, Cardiovasc Prevent Unit, Riyadh, Saudi Arabia
hcfmusp.author.externalALONSO, Rodrigo:Ctr Adv Metab Med & Nutr, Santiago, Chile
hcfmusp.author.externalAL-RASADI, Khalid:Sultan Qaboos Univ, Dept Biochem, Coll Med & Hlth Sci, Muscat, Oman; Sultan Qaboos Univ, Med Res Ctr, Muscat, Oman
hcfmusp.author.externalAL-SARRAF, Ahmad:Sabah Al Ahmad Cardiac Ctr, Kuwait, Kuwait
hcfmusp.author.externalAL-SAYED, Nasreen:Gulf Diabet & Endocrine Ctr, Manama, Bahrain
hcfmusp.author.externalARAUJO, Francisco:Portuguese Atherosclerosis Soc, Lisbon, Portugal
hcfmusp.author.externalASHAVAID, Tester F.:PD Hinduja Hosp & Med Res Ctr, Mumbai, Maharashtra, India
hcfmusp.author.externalBANACH, Maciej:Med Univ Lodz, Dept Hypertens, Lodz, Poland; Polish Mothers Mem Hosp Res Inst, Lodz, Poland; Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland
hcfmusp.author.externalBELIARD, Sophie:Aix Marseille Univ, AP HM, Hop Concept, Marseille, France; Aix Marseille Univ, Ctr Rech Cardiovasc & Nutr C2VN, INSERM 1260, INRAE,UMR 1263, Marseille, France
hcfmusp.author.externalBENN, Marianne:Univ Copenhagen, Rigshosp, Dept Clin Biochem, Copenhagen, Denmark; Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
hcfmusp.author.externalBINDER, Christoph J.:Med Univ Vienna, Dept Lab Med, Vienna, Austria
hcfmusp.author.externalBOGSRUD, Martin P.:Oslo Univ Hosp, Natl Advisory Unit Familial Hypercholesterolemia, Oslo, Norway
hcfmusp.author.externalBOURBON, Mafalda:Inst Nacl Saude Doutor Ricardo Jorge, Dept Promocao Saude & Prevencao Doencas Nao Trans, Unidade Invest & Desenvolvimento, Grp Invest Cardiovasc, Lisbon, Portugal; Univ Lisbon, Biosyst & Integrat Sci Inst BioISI, Fac Sci, Lisbon, Portugal
hcfmusp.author.externalCHLEBUS, Krzysztof:Med Univ Gdansk, Natl Ctr Familial Hypercholesterolaemia Gdansk, Dept Cardiol 1, Gdansk, Poland
hcfmusp.author.externalCORRAL, Pablo:FASTA Univ, Sch Med, Pharmacol Dept, Mar Del Plata, Argentina
hcfmusp.author.externalDAVLETOV, Kairat:Al Farabi Kazakh Natl Univ, Res Hlth Inst, Alma Ata, Kazakhstan
hcfmusp.author.externalDESCAMPS, Olivier S.:Ctr Hosp Jolimont, Ctr Rech Med Jolimont, Haine St Paul, Belgium
hcfmusp.author.externalDURST, Ronen:Hadassah Hebrew Univ, Cardiol Dept, Med Ctr, Jerusalem, Israel; Hadassah Hebrew Univ, Ctr Treatment & Prevent Atherosclerosis, Med Ctr, Jerusalem, Israel
hcfmusp.author.externalEZHOV, Marat:Minist Hlth Russian Federat, Natl Med Res Ctr Cardiol, Moscow, Russia
hcfmusp.author.externalGAITA, Dan:Univ Med & Farm Timisoara, Inst Boli Cardiovasc, Fundatia Cardioprevent, Timisoara, Romania
hcfmusp.author.externalGENEST, Jacques:McGill Univ, Res Inst, Hlth Ctr, Montreal, PQ, Canada
hcfmusp.author.externalGROSELJ, Urh:Univ Med Ctr, Dept Pediat Endocrinol Diabet & Metab, Ljubljana, Slovenia; Univ Childrens Hosp Ljubljana, Ljubljana, Slovenia; Univ Ljubljana, Fac Med, Ljubljana, Slovenia
hcfmusp.author.externalHARADA-SHIBA, Mariko:Natl Cerebral & Cardiovasc Ctr Res Inst, Osaka, Japan
hcfmusp.author.externalHOLVEN, Kirsten B.:Oslo Univ Hosp, Natl Advisory Unit Familial Hypercholesterolemia, Oslo, Norway
hcfmusp.author.externalKAYIKCIOGLU, Meral:Ege Univ, Dept Cardiol, Med Sch, Izmir, Turkey
hcfmusp.author.externalKHOVIDHUNKIT, Weerapan:Chulalongkorn Univ, Dept Med, Fac Med, Bangkok, Thailand; King Chulalongkorn Mem Hosp, Bangkok, Thailand
hcfmusp.author.externalLALIC, Katarina:Univ Belgrade, Clin Endocrinol Diabet & Metab Dis, Fac Med, Belgrade, Serbia
hcfmusp.author.externalLATKOVSKIS, Gustavs:Univ Latvia, Res Inst Cardiol & Regenerat Med, Pauls Stradins Clin Univ Hosp, Fac Med, Riga, Latvia
hcfmusp.author.externalLAUFS, Ulrich:Univ Klinikum Leipzig, Klin & Poliklin Kardiol, Leipzig, Germany
hcfmusp.author.externalLIBEROPOULOS, Evangelos:Univ Ioannina, Dept Internal Med, Fac Med, Ioannina, Greece
hcfmusp.author.externalLIMA-MARTINEZ, Marcos M.:Univ Oriente, Nucleo Bolivar, Ciudad Bolivar, Venezuela
hcfmusp.author.externalLIN, Jie:Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Anzhen Hosp, Beijing, Peoples R China
hcfmusp.author.externalMAHER, Vincent:Tallaght Univ Hosp, Adv Lipid Management & Res Ctr ALMAR, Dublin, Ireland
hcfmusp.author.externalMARAIS, A. David:Univ Cape Town, Chem Pathol, Hlth Sci Fac, Cape Town, South Africa
hcfmusp.author.externalMAERZ, Winfried:DACH Soc Prevent Heart & Circulatory Dis, Hamburg, Germany; Heidelberg Univ, Med Fac Mannheim, Dept Internal Med 5, Mannheim, Germany; Med Univ Graz, Klin Inst Med & Chem Labordiagnostik, Graz, Austria; Synlab Holding Deutschland, Synlab Akad, Mannheim, Germany; Synlab Holding Deutschland, Synlab Akad, Augsburg, Germany
hcfmusp.author.externalMIRRAKHIMOV, Erkin:Kyrgyz State Med Acad, Bishkek, Kyrgyzstan
hcfmusp.author.externalMISEREZ, Andre R.:Diagene Res Inst, Reinach, Switzerland; Swiss Soc Familial Forms Hypercholesterolemia SST, Reinach, Switzerland; Univ Basel, Fac Med, Basel, Switzerland
hcfmusp.author.externalMITCHENKO, Olena:Natl Acad Med Sci, Inst Cardiol, Dyslipidaemia Dept, Kiev, Ukraine
hcfmusp.author.externalNAWAWI, Hapizah:Univ Teknol MARA UiTM, Inst Pathol, Lab & Forens Med I PPerForM, Sungai Buloh, Selangor, Malaysia; Univ Teknol MARA UiTM, Fac Med, Sungai Buloh, Selangor, Malaysia
hcfmusp.author.externalNORDESTGAARD, Borge G.:Univ Copenhagen, Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen, Denmark
hcfmusp.author.externalPANAYIOTOU, Andrie G.:Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus
hcfmusp.author.externalPARAGH, Gyorgy:Univ Debrecen, Dept Internal Med, Fac Med, Debrecen, Hungary
hcfmusp.author.externalPETRULIONIENE, Zaneta:Vilnius Univ, Fac Med, Vilnius, Lithuania; Vilnius Univ Hosp Santaros Klinikos, Vilnius, Lithuania
hcfmusp.author.externalPOJSKIC, Belma:Cantonal Hosp Zenica, Zenica, Bosnia & Herceg
hcfmusp.author.externalPOSTADZHIYAN, Arman:Med Univ Sofia, Sofia, Bulgaria
hcfmusp.author.externalRASLOVA, Katarina:Slovak Med Univ Bratislava, Coordinat Ctr Familial Hyperlipidemias, Bratislava, Slovakia
hcfmusp.author.externalREDA, Ashraf:Menoufia Univ, Cardiol Dept, Fac Med, Al Minufiyah, Egypt
hcfmusp.author.externalREINER, Zeljko:Univ Zagreb, Univ Hosp Ctr Zagreb, Dept Internal Med, Zagreb, Croatia; Univ Zagreb, Sch Med, Zagreb, Croatia
hcfmusp.author.externalSADIQ, Fouzia:Shifa e Tameer Millat Univ, Directorate Res, Islamabad, Pakistan
hcfmusp.author.externalSADOH, Wilson Ehidiamen:Univ Benin, Dept Child Hlth, Teaching Hosp, Benin, Nigeria
hcfmusp.author.externalSCHUNKERT, Heribert:Tech Univ Munich, German Heart Ctr Munich, Clin Heart & Circulatory Dis, Munich, Germany; German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany
hcfmusp.author.externalSHEK, Aleksandr B.:Minist Hlth Republ Uzbekistan, Coronary Heart Dis & Atherosclerosis Dept, Republican Specialized Ctr Cardiol, Tashkent, Uzbekistan
hcfmusp.author.externalSTOLL, Mario:Comis Nacl Salud Cardiovasc, GENYCO Program, Montevideo, Uruguay
hcfmusp.author.externalSTROES, Erik:Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands
hcfmusp.author.externalSU, Ta-Chen:Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan; Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei, Taiwan
hcfmusp.author.externalSUBRAMANIAM, Tavintharan:Admiralty Med Ctr, Singapore, Singapore; Khoo Teck Puat Hosp, Yishun Hlth, Singapore, Singapore
hcfmusp.author.externalSUSEKOV, Andrey V.:Minist Hlth, Acad Postgrad Med Educ, Fac Clin Pharmacol & Therapeut, Moscow, Russia
hcfmusp.author.externalTILNEY, Myra:Mater Dei Hosp, Lipid Clin, Msida, Malta; Univ Malta, Fac Med & Surg, Dept Med, Msida, Malta
hcfmusp.author.externalTOMLINSON, Brian:Macau Univ Sci & Technol, Fac Med, Macau, Peoples R China
hcfmusp.author.externalTRUONG, Thanh Huong:Hanoi Med Univ, Vietnam Natl Heart Inst, Bach Mai Hosp, Hanoi, Vietnam; Hanoi Med Univ, Dept Cardiol, Hanoi, Vietnam
hcfmusp.author.externalTSELEPIS, Alexandros D.:Univ Ioannina, Atherothrombosis Res Ctr, Ioannina, Greece
hcfmusp.author.externalTYBJAERG-HANSEN, Anne:Univ Copenhagen, Rigshosp, Dept Clin Biochem, Copenhagen, Denmark; Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark
hcfmusp.author.externalCARDENAS, Alejandra Vazquez:Univ Autonoma Guadalajara, Fac Med, Zapopan, Mexico
hcfmusp.author.externalVIIGIMAA, Margus:Tallinn Univ Technol, North Estonia Med Ctr, Tallinn, Estonia
hcfmusp.author.externalWANG, Luya:Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Anzhen Hosp, Beijing, Peoples R China
hcfmusp.author.externalYAMASHITA, Shizuya:Rinku Gen Med Ctr, Osaka, Japan
hcfmusp.author.externalTOKGOZOGLU, Lale:Hacettepe Univ, Dept Cardiol, Ankara, Turkey
hcfmusp.author.externalCATAPANO, Alberico L.:Univ Milan, Dept Pharmacol & Biomol Sci, Ctr Epidemiol & Prevent Pharmacol, Lab Lipoproteins Immun & Atherosclerosis, Milan, Italy; Ist Ricovero & Cura Carattere Sci IRCCS MultiMed, Milan, Italy
hcfmusp.author.externalRAY, Kausik K.:Imperial Coll London, Sch Publ Hlth, Dept Primary Care & Publ Hlth, Imperial Ctr Cardiovasc Dis Prevent, London, England
hcfmusp.citation.scopus148
hcfmusp.contributor.author-fmusphcRAUL DIAS DOS SANTOS FILHO
hcfmusp.description.beginpage1713
hcfmusp.description.endpage1725
hcfmusp.description.issue10312
hcfmusp.description.volume398
hcfmusp.origemWOS
hcfmusp.origem.pubmed34506743
hcfmusp.origem.scopus2-s2.0-85115425381
hcfmusp.origem.wosWOS:000715856000025
hcfmusp.publisher.cityNEW YORKeng
hcfmusp.publisher.countryUSAeng
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