Genomic constellation of human Rotavirus A strains identified in Northern Brazil: a 6-year follow-up (2010-2016)

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA-SALES, Marcelle
dc.contributor.authorLEAL, Elcio
dc.contributor.authorMILAGRES, Flavio Augusto de Padua
dc.contributor.authorBRUSTULIN, Rafael
dc.contributor.authorMORAIS, Vanessa dos Santos
dc.contributor.authorMARCATTI, Roberta
dc.contributor.authorARAUJO, Emerson Luiz Lima
dc.contributor.authorWITKIN, Steven S.
dc.contributor.authorDENG, Xutao
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorDELWART, Eric
dc.contributor.authorLUCHS, Adriana
dc.contributor.authorCOSTA, Antonio Charlys da
dc.date.accessioned2021-02-18T13:30:29Z
dc.date.available2021-02-18T13:30:29Z
dc.date.issued2020
dc.description.abstractSurveillance of Rotavirus A (RVA) throughout the national territory is important to establish a more complete epidemiological-molecular scenario of this virus circulation in Brazil. The aim of the present study was to investigate the genetic diversity of RVA strains circulating in Tocantins State (Northern Brazil) during six years of post-vaccination followup (2010-2016). A total of 248 stool samples were screened by next generation sequencing and 107 (43.1%) nearly full length RVA genome sequences were obtained; one sample was co-infected with two RVA strains (G2/G8P[4]). Six G and P genotypes combinations were detected: G12P[8] strains (78.6%). as well as the G3P[8] (9.3%) and G1P[8] (0.9%) were associated with a Wa-like genogroup backbone. All G21 3 [4] (5.6%) and G8P[41 (2.8%) strains, including the mixed G2/G81 3 141 infection (0.9%) showed the DS-1-like genetic background. The two G12P[4] strains (1.9%) were associated with distinct genetic backbones: Wa-like and DS-1-like. The phylogenetic analysis revealed the circulation of lineages G1-I, G2-IV, G3-11E, G8-I and G12-111, and P[4]-V and P[8]-Ill of the VP7 and VP4 genes, respectively. Conserved clustering pattern and low genetic diversity were observed regarding VP1-VP3 and VP6, as well as NSP1-5 segments. We identified the same RVA circulation pattern reported in other Brazilian regions in the period of 2010-2016, suggesting that rural and low-income areas may not have a different RVA genotypic distribution compared to other parts of the country. The unique presentation of whole-genome data of RVA strains detected in the Tocantins State provides a baseline for monitoring variations in the genetic composition of RVA in this area.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/12944-9, 2017/00021-9, 2019/21706-5]
dc.description.sponsorshipCNPqNational Council for Scientific and Technological Development (CNPq) [430181/2018-3, 302677/2019-4]
dc.identifier.citationREVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.62, article ID e98, 13p, 2020
dc.identifier.doi10.1590/S1678-9946202062098
dc.identifier.eissn1678-9946
dc.identifier.issn0036-4665
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39231
dc.language.isoeng
dc.publisherINST MEDICINA TROPICAL SAO PAULOeng
dc.relation.ispartofRevista do Instituto de Medicina Tropical de Sao Paulo
dc.rightsopenAccesseng
dc.rights.holderCopyright INST MEDICINA TROPICAL SAO PAULOeng
dc.subjectAcute gastroenteritiseng
dc.subjectRotavirus Aeng
dc.subjectBrazileng
dc.subjectPost-vaccineeng
dc.subjectGenomic Constellationeng
dc.subject.otherg8 strainseng
dc.subject.othervaccineeng
dc.subject.othergenotypeeng
dc.subject.otherds-1-likeeng
dc.subject.othergastroenteritiseng
dc.subject.otherclassificationeng
dc.subject.othersurveillanceeng
dc.subject.otherprevalenceeng
dc.subject.otherdiversityeng
dc.subject.otheremergenceeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosParasitologyeng
dc.subject.wosTropical Medicineeng
dc.titleGenomic constellation of human Rotavirus A strains identified in Northern Brazil: a 6-year follow-up (2010-2016)eng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalSILVA-SALES, Marcelle:Univ Fed Goias, Inst Patol Trop & Saude Publ, Lab Virol & Cult Celular, Goiania, Go, Brazil
hcfmusp.author.externalLEAL, Elcio:Univ Fed Para, Inst Ciencias Biol, Belem, Para, Brazil
hcfmusp.author.externalMILAGRES, Flavio Augusto de Padua:Univ Fed Tocantins, Palmas, Tocantins, Brazil; Lab Cent Saude Publ Estado Tocantins, Palmas, Tocantins, Brazil
hcfmusp.author.externalBRUSTULIN, Rafael:Univ Fed Tocantins, Palmas, Tocantins, Brazil; Lab Cent Saude Publ Estado Tocantins, Palmas, Tocantins, Brazil
hcfmusp.author.externalARAUJO, Emerson Luiz Lima:Minist Saude, Secretaria Vigilancia Saude, Dept Articulacao Estrateg Vigilancia Saude, Coordenacao Geral Labs Saude Publ, Brasilia, DF, Brazil
hcfmusp.author.externalDENG, Xutao:Vitalant Res Inst, San Francisco, CA USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
hcfmusp.author.externalDELWART, Eric:Vitalant Res Inst, San Francisco, CA USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
hcfmusp.author.externalLUCHS, Adriana:Adolfo Lutz Inst, Ctr Virol, Nucleo Doencas Enter, Av Dr Arnaldo 355, BR-01246902 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcVANESSA DOS SANTOS MORAIS
hcfmusp.contributor.author-fmusphcROBERTA MARCATTI DE AZEVEDO
hcfmusp.contributor.author-fmusphcSTEVEN SOL WITKIN
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.contributor.author-fmusphcANTONIO CHARLYS DA COSTA
hcfmusp.description.articlenumbere98
hcfmusp.description.volume62
hcfmusp.origemWOS
hcfmusp.origem.pubmed33331517
hcfmusp.origem.scieloSCIELO:S0036-46652020000100248
hcfmusp.origem.scopus2-s2.0-85098604957
hcfmusp.origem.wosWOS:000600366000001
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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