Strategies to manage obstructive sleep apnea to decrease the burden of atrial fibrillation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGOES, Creuza M.
dc.contributor.authorFALCOCHIO, Paola P. N. F.
dc.contributor.authorDRAGER, Luciano F.
dc.date.accessioned2019-05-30T13:27:22Z
dc.date.available2019-05-30T13:27:22Z
dc.date.issued2018
dc.description.abstractIntroduction: In the last decades, consistent data derived from experimental, epidemiological, and clinical studies pointed obstructive sleep apnea (OSA), the most common sleep disordered breathing worldwide, as a potential risk factor for incidence and recurrence of atrial fibrillation (AF). Areas covered: This review article describes the impact of OSA on AF and discusses potential strategies for managing OSA in the AF scenario. Expert commentary: Untreated OSA seems to be one important predictor of AF treatment failure after chemical or electrical cardioversion as well as after a successful AF ablation. There is biological plausibility for this association including the effects of intermittent hypoxia and sleep fragmentation promoting sympathetic activation, blood pressure instability, inflammation, and oxidative stress. The negative swings derived from the obstructive events also increases left ventricle afterload contributing to cardiac remodeling. Altogether, these factors provide a structural and electrical substrate for AF. Despite this evidence, however, OSA remains still poorly recognized and consequently undertreated in clinical practice. Therefore, active programs to incorporate valid screening for cardiologists to work in partnership to sleep medicine experts may ultimately contribute to decreasing the burden of AF.eng
dc.description.indexMEDLINEeng
dc.identifier.citationEXPERT REVIEW OF CARDIOVASCULAR THERAPY, v.16, n.10, p.707-713, 2018
dc.identifier.doi10.1080/14779072.2018.1515013
dc.identifier.eissn1744-8344
dc.identifier.issn1477-9072
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31635
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INCeng
dc.relation.ispartofExpert Review of Cardiovascular Therapy
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright TAYLOR & FRANCIS INCeng
dc.subjectSleep apneaeng
dc.subjectatrial fibrillationeng
dc.subjectscreeningeng
dc.subjecttreatmenteng
dc.subjectcardiovascular diseaseeng
dc.subject.otherpositive airway pressureeng
dc.subject.otherrenal sympathetic denervationeng
dc.subject.othernocturnal arrhythmiaseng
dc.subject.otherheart-failureeng
dc.subject.otherriskeng
dc.subject.otherrecurrenceeng
dc.subject.othertermeng
dc.subject.otherassociationeng
dc.subject.otherprevalenceeng
dc.subject.othermechanismseng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.titleStrategies to manage obstructive sleep apnea to decrease the burden of atrial fibrillationeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcCREUZA MACEDO GOES ROCHA
hcfmusp.contributor.author-fmusphcPAOLA PRETTI NUNES FERREIRA FALCOCHIO
hcfmusp.contributor.author-fmusphcLUCIANO FERREIRA DRAGER
hcfmusp.description.beginpage707
hcfmusp.description.endpage713
hcfmusp.description.issue10
hcfmusp.description.volume16
hcfmusp.origemWOS
hcfmusp.origem.pubmed30136604
hcfmusp.origem.scopus2-s2.0-85054412794
hcfmusp.origem.wosWOS:000460937500003
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
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