The Changing Epidemiology of Hepatitis C Virus Acquisition Among HIV-Infected Individuals in Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFERRUFINO, Rosario Quiroga
dc.contributor.authorBIERRENBACH, Ana Luiza
dc.contributor.authorRODRIGUES, Camila
dc.contributor.authorFIGUEIREDO, Gerusa Maria
dc.contributor.authorGLEISON, Daniel
dc.contributor.authorYAPURA, Silvia
dc.contributor.authorMATOS, Maria Laura Mariano de
dc.contributor.authorVASCONCELOS, Ricardo
dc.contributor.authorWITKIN, Steven Sol
dc.contributor.authorMENDES-CORREA, Maria Cassia
dc.date.accessioned2023-02-23T14:56:57Z
dc.date.available2023-02-23T14:56:57Z
dc.date.issued2023
dc.description.abstractIdentification of mechanisms of hepatitis C virus (HCV) acquisition among HIV-infected people is critical for prevention guidance. The aim of this study was to investigate risk factors for HCV infection and variations in HCV genotype distribution in a cohort of HIV-HCV coinfected patients in Brazil. This was a cross-sectional observational epidemiological study of a cohort of HIV-HCV coinfected individuals seen at a referral center for HIV-infected patients in the city of Sao Paulo between January and December 2017. The time of HCV acquisition, as determined by chart review, was categorized as before 2000, between 2000 and 2009, and from 2010 onward. HCV genotypes were determined by gene amplification and analysis. Among 3,143 HIV-infected individuals analyzed, 362 (11.5%) were HCV-HIV coinfected. Overall, the reported modes of HCV acquisition were sexual exposure in 172 (47.5%), injection drug use (IDU) in 86 (23.8%), use of inhaled drugs in 67 (18.5%) and blood transfusion in 10 (2.8%) individuals. All individuals who acquired HCV after IDU became infected before 2010. HCV acquisition by sexual contact was reported by 26.4%, 65.9%, and 63.8% of patients before 2000, between 2000 and 2009, and from 2010, respectively. There was an increase (p < .001) in the proportion of cases due to sexual transmission from the period before 2000 (26.4%) to between 2000 and 2009 (65.9%). There was no corresponding increase from 2000 and 2009 to after 2010 (p = .751). HCV genotype 1 was most prevalent at all time periods. The genotype 3 frequency decreased over time (test for trend p < .001), whereas genotype 4, extremely uncommon before 2010, became the second most prevalent genotype from 2010 onward. In HIV-infected individuals in Sao Paulo, Brazil, sexual transmission has replaced IDU as the most frequent mode of HCV acquisition.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipGilead Sciences [IN-US-334-1670]
dc.identifier.citationAIDS RESEARCH AND HUMAN RETROVIRUSES, v.39, n.1, p.44-49, 2023
dc.identifier.doi10.1089/aid.2021.0197
dc.identifier.eissn1931-8405
dc.identifier.issn0889-2229
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/51583
dc.language.isoeng
dc.publisherMARY ANN LIEBERT, INCeng
dc.relation.ispartofAIDS Research and Human Retroviruses
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright MARY ANN LIEBERT, INCeng
dc.subjecthepatitis Ceng
dc.subjectHIVeng
dc.subjectcoinfectioneng
dc.subjectepidemiologyeng
dc.subjecttransmissioneng
dc.subject.otherinjection-drug userseng
dc.subject.otherhuman-immunodeficiencyeng
dc.subject.othergenotype distributioneng
dc.subject.otherhcveng
dc.subject.otherprevalenceeng
dc.subject.othermeneng
dc.subject.othertransmissioneng
dc.subject.othercoinfectioneng
dc.subject.othersexeng
dc.subject.wosImmunologyeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosVirologyeng
dc.titleThe Changing Epidemiology of Hepatitis C Virus Acquisition Among HIV-Infected Individuals in Brazileng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalBIERRENBACH, Ana Luiza:Hosp Sirio Libanes, Inst Ensino & Pesquisa, Sao Paulo, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcROSARIO QUIROGA FERRUFINO
hcfmusp.contributor.author-fmusphcCAMILA RODRIGUES
hcfmusp.contributor.author-fmusphcGERUSA MARIA FIGUEIREDO
hcfmusp.contributor.author-fmusphcDANIEL GLEISON CARVALHO
hcfmusp.contributor.author-fmusphcSILVIA MONICA YAPURA JALDIN
hcfmusp.contributor.author-fmusphcMARIA LAURA MARIANO DE MATOS
hcfmusp.contributor.author-fmusphcRICARDO DE PAULA VASCONCELOS
hcfmusp.contributor.author-fmusphcSTEVEN SOL WITKIN
hcfmusp.contributor.author-fmusphcMARIA CASSIA JACINTHO MENDES CORREA
hcfmusp.description.beginpage44
hcfmusp.description.endpage49
hcfmusp.description.issue1
hcfmusp.description.volume39
hcfmusp.origemWOS
hcfmusp.origem.pubmed36301937
hcfmusp.origem.scopus2-s2.0-85146364959
hcfmusp.origem.wosWOS:000892834300001
hcfmusp.publisher.cityNEW ROCHELLEeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-05-17
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