The effect of prenatally administered vaginal progesterone on uterine artery Doppler in asymptomatic twin pregnancies

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorAGRA, Isabela K. R.
dc.contributor.authorBRIZOT, Maria L.
dc.contributor.authorMIYADAHIRA, Mariana Y.
dc.contributor.authorCARVALHO, Mario H. B.
dc.contributor.authorFRANCISCO, Rossana P. V.
dc.contributor.authorZUGAIB, Marcelo
dc.date.accessioned2016-12-20T16:40:18Z
dc.date.available2016-12-20T16:40:18Z
dc.date.issued2016
dc.description.abstractObjectives: This study investigated the influence of vaginal progesterone on uterine circulation in asymptomatic twin gestations. Study design: This study was a secondary analysis of a randomized, double-blind, placebo-controlled trial of twin pregnancies exposed to vaginal progesterone or placebo. We included all trial participants who had undergone uterine artery pulsatility index evaluation at the time of randomization. During each ultrasound examination, the uterine artery pulsatility index was evaluated transabdominally. The mean uterine artery pulsatility index between the progesterone and placebo groups were compared for each gestational age, starting between 18 to 34 weeks and 6 days and were analyzed at three (Time 1), six (Time 2) and nine (Time 3) weeks after randomization. Results: The final analysis included 128 women in the progesterone group and 122 women in the placebo group. The baseline characteristics were similar in both groups. No difference in the mean uterine artery pulsatility index was observed between the progesterone and placebo groups at each week of gestation or throughout gestation. Conclusions: In twin pregnancies, the use of vaginal progesterone in the second half of pregnancy does not influence uterine circulation.
dc.description.indexMEDLINE
dc.identifier.citationEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, v.205, p.11-14, 2016
dc.identifier.doi10.1016/j.ejogrb.2016.08.016
dc.identifier.eissn1872-7654
dc.identifier.issn0301-2115
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/17109
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectTwin pregnancy
dc.subjectUterine circulation
dc.subjectProgesterone
dc.subjectDoppler velocimetry
dc.subject.otherhuman trophoblast invasion
dc.subject.otherfetal growth restriction
dc.subject.otherpreterm birth
dc.subject.otherblood-flow
dc.subject.othertransformation
dc.subject.otherpreeclampsia
dc.subject.othercirculation
dc.subject.otherprevention
dc.subject.wosObstetrics & Gynecology
dc.subject.wosReproductive Biology
dc.titleThe effect of prenatally administered vaginal progesterone on uterine artery Doppler in asymptomatic twin pregnancies
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcISABELA KARINE RODRIGUES AGRA
hcfmusp.contributor.author-fmusphcMARIA DE LOURDES BRIZOT
hcfmusp.contributor.author-fmusphcMARIANA YUMI MIYADAHIRA
hcfmusp.contributor.author-fmusphcMARIO HENRIQUE BURLACCHINI DE CARVALHO
hcfmusp.contributor.author-fmusphcROSSANA PULCINELI VIEIRA FRANCISCO
hcfmusp.contributor.author-fmusphcMARCELO ZUGAIB
hcfmusp.description.beginpage11
hcfmusp.description.endpage14
hcfmusp.description.volume205
hcfmusp.origemWOS
hcfmusp.origem.pubmed27552173
hcfmusp.origem.scopus2-s2.0-84982276881
hcfmusp.origem.wosWOS:000385323100003
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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hcfmusp.scopus.lastupdate2024-05-10
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