Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults

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art_RODRIGUES_Metabolomic_Evaluation_of_Chronic_Periodontal_Disease_in_Older_2021.PDF (482.16 KB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HINDAWI LTD
Autores
RODRIGUES, Wellington F.
MIGUEL, Camila B.
AGOSTINHO, Ferdinando
LAZO-CHICA, Javier E.
SCAPIN, Sandra M. Naressi
NAPIMOGA, Marcelo H.
TRINDADE-DA-SILVA, Carlos A.
Citação
MEDIATORS OF INFLAMMATION, v.2021, article ID 1796204, 8p, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Research participants were selected from long-term institutions in Brazil. Participants were individuals aged 65 years or older, healthy, or with chronic periodontal disease. Gas chromatography/mass spectrometry was used to evaluate potential biomarkers in 120 crevicular fluid samples. We identified 969 metabolites in the individuals. Of these, 15 metabolites showed a variable importance with projection score>1 and were associated with periodontal disease. Further analysis showed that among the 15 metabolites, two (5-aminovaleric acid and serine, 3TMS derivative) were found at higher concentrations in the crevicular fluid, indicating their potential diagnostic power for periodontal disease in older adults. Our findings indicated that some metabolites are present at high concentrations in the crevicular fluid in older adults with periodontal disease and can be used as biomarkers of periodontal disease.
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URI
https://observatorio.fm.usp.br/handle/OPI/44386
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/13